Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways

The human respiratory tract contains a highly adapted microbiota including commensal and opportunistic pathogens. Noncapsulated or nontypable Haemophilus influenzae (NTHi) is a human-restricted member of the normal airway microbiota in healthy carriers and an opportunistic pathogen in immunocompromised individuals. The duality of NTHi as a colonizer and as a symptomatic infectious agent is closely related to its adaptation to the host, which in turn greatly relies on the genetic plasticity of the bacterium and is facilitated by its condition as a natural competent. The variable genotype of NTHi accounts for its heterogeneous gene expression and variable phenotype, leading to differential host-pathogen interplay among isolates. Here we review our current knowledge of NTHi diversity in terms of genotype, gene expression, antigenic variation, and the phenotypes associated with colonization and pathogenesis. The potential benefits of NTHi diversity studies discussed herein include the unraveling of pathogenicity clues, the generation of tools to predict virulence from genomic data, and the exploitation of a unique natural system for the continuous monitoring of long-term bacterial evolution in human airways exposed to noxious agents. Finally, we highlight the challenge of monitoring both the pathogen and the host in longitudinal studies, and of applying comparative genomics to clarify the meaning of the vast NTHi genetic diversity and its translation to virulence phenotypes.

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Main Authors: Garmendia, Juncal, Martí-Lliteras, Pau, Moleres, Javier, Puig, Carmen, Bengoechea, José Antonio
Other Authors: Nafarroako Gobernua
Format: artículo biblioteca
Published: Sociedad Española de Microbiología 2012
Subjects:Haemophilus infl uenzae, Noncapsulated/nontypable Haemophilus infl uenzae (NTHi), Pathogen-host interplay, Genetic diversity, Virulence phenotype,
Online Access:http://hdl.handle.net/10261/147442
http://dx.doi.org/10.13039/501100004587
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spelling dig-idab-es-10261-1474422017-06-08T09:00:47Z Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways Garmendia, Juncal Martí-Lliteras, Pau Moleres, Javier Puig, Carmen Bengoechea, José Antonio Nafarroako Gobernua Centro de Investigación Biomédica en Red Enfermedades Respiratorias (España) Instituto de Salud Carlos III Haemophilus infl uenzae Noncapsulated/nontypable Haemophilus infl uenzae (NTHi) Pathogen-host interplay Genetic diversity Virulence phenotype The human respiratory tract contains a highly adapted microbiota including commensal and opportunistic pathogens. Noncapsulated or nontypable Haemophilus influenzae (NTHi) is a human-restricted member of the normal airway microbiota in healthy carriers and an opportunistic pathogen in immunocompromised individuals. The duality of NTHi as a colonizer and as a symptomatic infectious agent is closely related to its adaptation to the host, which in turn greatly relies on the genetic plasticity of the bacterium and is facilitated by its condition as a natural competent. The variable genotype of NTHi accounts for its heterogeneous gene expression and variable phenotype, leading to differential host-pathogen interplay among isolates. Here we review our current knowledge of NTHi diversity in terms of genotype, gene expression, antigenic variation, and the phenotypes associated with colonization and pathogenesis. The potential benefits of NTHi diversity studies discussed herein include the unraveling of pathogenicity clues, the generation of tools to predict virulence from genomic data, and the exploitation of a unique natural system for the continuous monitoring of long-term bacterial evolution in human airways exposed to noxious agents. Finally, we highlight the challenge of monitoring both the pathogen and the host in longitudinal studies, and of applying comparative genomics to clarify the meaning of the vast NTHi genetic diversity and its translation to virulence phenotypes. This work has been funded by grants from the Health Institute Carlos III (ISCIII), grant PI09/00130, and from the Health Department of the Government of Navarra, Spain (Call 2011) to J.G., and by grant PI09/01904 (ISCIII) to J. Liñares. CIBERES is an initiative from ISCIII, Spain. Peer Reviewed 2017-03-28T09:29:15Z 2017-03-28T09:29:15Z 2012 2017-03-28T09:29:16Z artículo http://purl.org/coar/resource_type/c_6501 issn: 1139-6709 e-issn: 1618-1905 International Microbiology 15: 159-172 (2012) http://hdl.handle.net/10261/147442 10.2436/20.1501.01.169 http://dx.doi.org/10.13039/501100004587 http://doi.org/10.2436/20.1501.01.169 open Sociedad Española de Microbiología
institution IDAB ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-idab-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IDAB España
topic Haemophilus infl uenzae
Noncapsulated/nontypable Haemophilus infl uenzae (NTHi)
Pathogen-host interplay
Genetic diversity
Virulence phenotype
Haemophilus infl uenzae
Noncapsulated/nontypable Haemophilus infl uenzae (NTHi)
Pathogen-host interplay
Genetic diversity
Virulence phenotype
spellingShingle Haemophilus infl uenzae
Noncapsulated/nontypable Haemophilus infl uenzae (NTHi)
Pathogen-host interplay
Genetic diversity
Virulence phenotype
Haemophilus infl uenzae
Noncapsulated/nontypable Haemophilus infl uenzae (NTHi)
Pathogen-host interplay
Genetic diversity
Virulence phenotype
Garmendia, Juncal
Martí-Lliteras, Pau
Moleres, Javier
Puig, Carmen
Bengoechea, José Antonio
Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways
description The human respiratory tract contains a highly adapted microbiota including commensal and opportunistic pathogens. Noncapsulated or nontypable Haemophilus influenzae (NTHi) is a human-restricted member of the normal airway microbiota in healthy carriers and an opportunistic pathogen in immunocompromised individuals. The duality of NTHi as a colonizer and as a symptomatic infectious agent is closely related to its adaptation to the host, which in turn greatly relies on the genetic plasticity of the bacterium and is facilitated by its condition as a natural competent. The variable genotype of NTHi accounts for its heterogeneous gene expression and variable phenotype, leading to differential host-pathogen interplay among isolates. Here we review our current knowledge of NTHi diversity in terms of genotype, gene expression, antigenic variation, and the phenotypes associated with colonization and pathogenesis. The potential benefits of NTHi diversity studies discussed herein include the unraveling of pathogenicity clues, the generation of tools to predict virulence from genomic data, and the exploitation of a unique natural system for the continuous monitoring of long-term bacterial evolution in human airways exposed to noxious agents. Finally, we highlight the challenge of monitoring both the pathogen and the host in longitudinal studies, and of applying comparative genomics to clarify the meaning of the vast NTHi genetic diversity and its translation to virulence phenotypes.
author2 Nafarroako Gobernua
author_facet Nafarroako Gobernua
Garmendia, Juncal
Martí-Lliteras, Pau
Moleres, Javier
Puig, Carmen
Bengoechea, José Antonio
format artículo
topic_facet Haemophilus infl uenzae
Noncapsulated/nontypable Haemophilus infl uenzae (NTHi)
Pathogen-host interplay
Genetic diversity
Virulence phenotype
author Garmendia, Juncal
Martí-Lliteras, Pau
Moleres, Javier
Puig, Carmen
Bengoechea, José Antonio
author_sort Garmendia, Juncal
title Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways
title_short Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways
title_full Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways
title_fullStr Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways
title_full_unstemmed Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: Adaptation and pathogenesis in the human airways
title_sort genotypic and phenotypic diversity of the noncapsulated haemophilus influenzae: adaptation and pathogenesis in the human airways
publisher Sociedad Española de Microbiología
publishDate 2012
url http://hdl.handle.net/10261/147442
http://dx.doi.org/10.13039/501100004587
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