Berry-enriched diet in salt-sensitive hypertensive rats: metabolic fate of (Poly)phenols and the role of Gut Microbiota
Diets rich in (poly)phenols are associated with a reduced reduction in the incidence of cardiovascular disorders. While the absorption and metabolism of (poly)phenols has been described, it is not clear how their metabolic fate is affected under pathological conditions. This study evaluated the metabolic fate of berry (poly)phenols in an in vivo model of hypertension as well as the associated microbiota response. Dahl salt-sensitive rats were fed either a low-salt diet (0.26% NaCl) or a high-salt diet (8% NaCl), with or without a berry mixture (blueberries, blackberries, raspberries, Portuguese crowberry and strawberry tree fruit) for 9 weeks. The saltenriched diet promoted an increase in the urinary excretion of berry (poly)phenol metabolites, while the abundance of these metabolites decreased in faeces, as revealed by UPLC¿MS/MS. Moreover, salt and berries modulated gut microbiota composition as demonstrated by 16S rRNA analysis. Some changes in the microbiota composition were associated with the high-salt diet and revealed an expansion of the families Proteobacteria and Erysipelotrichaceae. However, this effect was mitigated by the dietary supplementation with berries. Alterations in the metabolic fate of (poly)phenols occur in parallel with the modulation of gut microbiota in hypertensive rats. Thus, beneficial effects of (poly)phenols could be related with these interlinked modifications, between metabolites and microbiota environments.
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Published: |
Multidisciplinary Digital Publishing Institute
2019-11-03
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| Subjects: | Polyphenols, Cardiovascular, Dysbiosis, Gut metabolism, High salt intake, |
| Online Access: | http://hdl.handle.net/10261/202766 http://dx.doi.org/10.13039/501100001871 http://dx.doi.org/10.13039/501100002428 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100001665 http://dx.doi.org/10.13039/501100000780 |
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