Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease

Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease

This article belongs to the Section Phytochemicals and Human Health.

Saved in:
Bibliographic Details
Main Authors: Preciado, Silvia, Martínez-Villaluenga, Cristina, Rico, Daniel, Muntión, Sandra, García-Macías, María-Carmen, Navarro-Bailón, Almudena, Martín Diana, Ana Belén, Sánchez-Guijo, Fermín
Other Authors: Ministerio de Ciencia, Innovación y Universidades (España)
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2023
Subjects:Wheat bran, Mouse model, Ferulic acid, Immunomodulation, Graft-versus-host disease, Anti-inflammatory activity,
Online Access:http://hdl.handle.net/10261/345124
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-ictan-es-10261-345124
record_format koha
spelling dig-ictan-es-10261-3451242024-02-02T13:26:18Z Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease Preciado, Silvia Martínez-Villaluenga, Cristina Rico, Daniel Muntión, Sandra García-Macías, María-Carmen Navarro-Bailón, Almudena Martín Diana, Ana Belén Sánchez-Guijo, Fermín Ministerio de Ciencia, Innovación y Universidades (España) Ministerio de Ciencia e Innovación (España) Instituto de Salud Carlos III Agencia Estatal de Investigación (España) Junta de Castilla y León Fundacion de la Sociedad Española de Hematología y Hemoterapia European Commission Wheat bran Mouse model Ferulic acid Immunomodulation Graft-versus-host disease Anti-inflammatory activity This article belongs to the Section Phytochemicals and Human Health. Graft-versus-host disease (GvHD) is a common and severe complication following allogeneic hematopoietic stem cell transplantation (HSCT). Its prevention and treatment is a major challenge. Ferulic acid (FA) has anti-inflammatory and antioxidant properties that could be attractive in this setting. Our aim was to evaluate a bioactive ingredient derived from wheat bran (WB), selected for its high concentration of FA, in a murine model of GvHD. The ingredient was obtained via a bioprocess involving hydrolysis and spray-drying. GvHD was induced via HSCT between MHC-mismatched mouse strains. FA treatment was administered orally. Survival and disease scores (weight loss, hunching, activity, fur texture, and skin integrity, each scored between 0 and 2 depending on disease severity) were recorded daily, histological evaluation was performed at the end of the experiment, and serum inflammatory cytokines were analyzed on days 9 and 28. Treatment with FA did not protect GvHD mice from death, nor did it diminish GvHD scores. However, histological analysis showed that ulcers with large areas of inflammatory cells, vessels, and keratin were less common in skin samples from FA-treated mice. Areas of intense inflammatory response were also seen in fewer small intestine samples from treated mice. In addition, a slight decrease in INF-γ and TNF-α expression was observed in the serum of treated mice on day 28. The results showed some local effect of the ingredient intervention, but that the dose used may not be sufficient to control or reduce the inflammatory response at the systemic level in mice with GvHD. Higher dosages of FA may have an impact when evaluating the immunomodulatory capabilities of the hydrolyzed WB ingredient. Thus, further experiments and the use of technological strategies that enrich the ingredients in soluble ferulic acid to improve its efficacy in this setting are warranted. This work was partially supported by Agencia Estatal de Investigación/FEDER, UE (AGL2017-83718-R), Instituto de Salud Carlos III (PI16/01407) and by Consejería de Educación (CAS079P17) and Consejería de Sanidad (GRS1879/A/18) of the Junta de Castilla y León. SP is supported by Fundación Española de Hematología y Hemoterapia (FEHH). SM is supported by RETIC program of ISCIII-European Regional Development Fund (RD21/0017/0006), “A way to make Europe”. Peer reviewed 2024-02-02T13:26:17Z 2024-02-02T13:26:17Z 2023 artículo Nutrients 15(21): 4582 (2023) http://hdl.handle.net/10261/345124 10.3390/nu15214582 2072-6643 37960235 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-83718-R/ES/VALORIZACION DE CEREALES INTEGRALES PARA EL DESARROLLO DE ALIMENTOS DE CARACTER INMUNOMODULADOR DIRIGIDOS A PACIENTES ONCOHEMATOLOGICOS/ Publisher's version https://doi.org/10.3390/nu15214582 Sí open application/pdf Multidisciplinary Digital Publishing Institute
institution ICTAN ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ictan-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del ICTAN España
language English
topic Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
spellingShingle Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
Preciado, Silvia
Martínez-Villaluenga, Cristina
Rico, Daniel
Muntión, Sandra
García-Macías, María-Carmen
Navarro-Bailón, Almudena
Martín Diana, Ana Belén
Sánchez-Guijo, Fermín
Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
description This article belongs to the Section Phytochemicals and Human Health.
author2 Ministerio de Ciencia, Innovación y Universidades (España)
author_facet Ministerio de Ciencia, Innovación y Universidades (España)
Preciado, Silvia
Martínez-Villaluenga, Cristina
Rico, Daniel
Muntión, Sandra
García-Macías, María-Carmen
Navarro-Bailón, Almudena
Martín Diana, Ana Belén
Sánchez-Guijo, Fermín
format artículo
topic_facet Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
author Preciado, Silvia
Martínez-Villaluenga, Cristina
Rico, Daniel
Muntión, Sandra
García-Macías, María-Carmen
Navarro-Bailón, Almudena
Martín Diana, Ana Belén
Sánchez-Guijo, Fermín
author_sort Preciado, Silvia
title Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_short Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_full Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_fullStr Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_full_unstemmed Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_sort effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
publisher Multidisciplinary Digital Publishing Institute
publishDate 2023
url http://hdl.handle.net/10261/345124
work_keys_str_mv AT preciadosilvia effectsofdietarysupplementationwithaferulicacidrichbioactivecomponentofwheatbraninamurinemodelofgraftversushostdisease
AT martinezvillaluengacristina effectsofdietarysupplementationwithaferulicacidrichbioactivecomponentofwheatbraninamurinemodelofgraftversushostdisease
AT ricodaniel effectsofdietarysupplementationwithaferulicacidrichbioactivecomponentofwheatbraninamurinemodelofgraftversushostdisease
AT muntionsandra effectsofdietarysupplementationwithaferulicacidrichbioactivecomponentofwheatbraninamurinemodelofgraftversushostdisease
AT garciamaciasmariacarmen effectsofdietarysupplementationwithaferulicacidrichbioactivecomponentofwheatbraninamurinemodelofgraftversushostdisease
AT navarrobailonalmudena effectsofdietarysupplementationwithaferulicacidrichbioactivecomponentofwheatbraninamurinemodelofgraftversushostdisease
AT martindianaanabelen effectsofdietarysupplementationwithaferulicacidrichbioactivecomponentofwheatbraninamurinemodelofgraftversushostdisease
AT sanchezguijofermin effectsofdietarysupplementationwithaferulicacidrichbioactivecomponentofwheatbraninamurinemodelofgraftversushostdisease
_version_ 1792484900364877824

Similar Items