Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention
Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This study aimed to examine the effects of the long-term consumption of supplements containing GCP, BG or the novel GCP/BG combination on lipid and glucose metabolism biomarkers in overweight/obese subjects who maintained their dietary habits and physical activity, hence addressing the difficulty that this population faces in adapting to lifestyle changes. A randomised, crossover, blind trial was carried out in 29 volunteers who consumed either GCP (300 mg), BG (2.5 g) or GCP/BG (300 mg + 2.5 g) twice a day for 8 weeks. Blood samples were collected, and blood pressure and body composition were measured at the beginning and end of each intervention. Total cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C) cholesterol, glycated haemoglobin, fasting glucose, insulin, aspartate transaminase, alanine transaminase and different hormones and adipokines were analysed. Only VLDL-C (p = 0.01) and diastolic blood pressure (p = 0.027) decreased after the intervention, especially with the BG supplement. There were no other significant changes in the analysed biomarkers. In conclusion, the regular intake of GCP, BG and GCP/BG without lifestyle changes is not an efficient strategy to improve lipid and glucose homeostasis in overweight/obese subjects.
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Multidisciplinary Digital Publishing Institute
2023-05-08
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Subjects: | Oat beta-glucan, Green coffee hydroxycinnamates, Obesity, Lipid metabolism, Glucose homeostasis, |
Online Access: | http://hdl.handle.net/10261/310509 |
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dig-ictan-es-10261-3105092023-06-08T14:30:54Z Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention García-Cordero, Joaquín Mateos, Raquel González-Rámila, Susana Seguido, Miguel A. Sierra-Cinos, José Luis Sarriá, Beatriz Bravo, Laura Ministerio de Economía y Competitividad (España) Comunidad de Madrid Interprofesional del Aceite de Orujo de Oliva Oat beta-glucan Green coffee hydroxycinnamates Obesity Lipid metabolism Glucose homeostasis Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This study aimed to examine the effects of the long-term consumption of supplements containing GCP, BG or the novel GCP/BG combination on lipid and glucose metabolism biomarkers in overweight/obese subjects who maintained their dietary habits and physical activity, hence addressing the difficulty that this population faces in adapting to lifestyle changes. A randomised, crossover, blind trial was carried out in 29 volunteers who consumed either GCP (300 mg), BG (2.5 g) or GCP/BG (300 mg + 2.5 g) twice a day for 8 weeks. Blood samples were collected, and blood pressure and body composition were measured at the beginning and end of each intervention. Total cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C) cholesterol, glycated haemoglobin, fasting glucose, insulin, aspartate transaminase, alanine transaminase and different hormones and adipokines were analysed. Only VLDL-C (p = 0.01) and diastolic blood pressure (p = 0.027) decreased after the intervention, especially with the BG supplement. There were no other significant changes in the analysed biomarkers. In conclusion, the regular intake of GCP, BG and GCP/BG without lifestyle changes is not an efficient strategy to improve lipid and glucose homeostasis in overweight/obese subjects. This research was funded by project AGL2015-69986-R from the Spanish Ministry of Economy and Competitivity. J.G.-C. had a predoctoral grant funded by Comunidad de Madrid (PEJD-2017-PRE_BIO-4225). M.A.S. had a predoctoral contract funded by Comunidad de Madrid (PEJD-2018-PRE/SAL-9104). S.G.-R. had a predoctoral contract funded by Interprofesional del Aceite de Orujo de Oliva (ORIVA). Peer reviewed 2023-06-04T10:19:21Z 2023-06-04T10:19:21Z 2023-05-08 2023-06-04T10:19:21Z artículo http://purl.org/coar/resource_type/c_6501 Nutrients 15(9): 2223 (2023) http://hdl.handle.net/10261/310509 10.3390/nu15092223 2072-6643 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//AGL2015-69986-R/ES/EFICACIA DE NUEVOS PRODUCTOS COMBINANDO HIDROXICINAMATOS Y BETA-GLUCANOS COMO HERRAMIENTA DIETETICA FRENTE A OBESIDAD Y DISFUNCIONES ASOCIADAS (HIPERGLICEMIA Y DISLIPEMIA)/ Publisher's version https://doi.org/10.3390/nu15092223 Sí open application/pdf Multidisciplinary Digital Publishing Institute |
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Oat beta-glucan Green coffee hydroxycinnamates Obesity Lipid metabolism Glucose homeostasis Oat beta-glucan Green coffee hydroxycinnamates Obesity Lipid metabolism Glucose homeostasis |
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Oat beta-glucan Green coffee hydroxycinnamates Obesity Lipid metabolism Glucose homeostasis Oat beta-glucan Green coffee hydroxycinnamates Obesity Lipid metabolism Glucose homeostasis García-Cordero, Joaquín Mateos, Raquel González-Rámila, Susana Seguido, Miguel A. Sierra-Cinos, José Luis Sarriá, Beatriz Bravo, Laura Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention |
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Obesity has reached pandemic proportions and has become a major health concern worldwide. Therefore, it is necessary to find new strategies against this condition and its associated comorbidities. Green coffee polyphenols (GCP) and oat beta-glucans (BGs) have proven their hypolipidaemic and hypoglycaemic effects. This study aimed to examine the effects of the long-term consumption of supplements containing GCP, BG or the novel GCP/BG combination on lipid and glucose metabolism biomarkers in overweight/obese subjects who maintained their dietary habits and physical activity, hence addressing the difficulty that this population faces in adapting to lifestyle changes. A randomised, crossover, blind trial was carried out in 29 volunteers who consumed either GCP (300 mg), BG (2.5 g) or GCP/BG (300 mg + 2.5 g) twice a day for 8 weeks. Blood samples were collected, and blood pressure and body composition were measured at the beginning and end of each intervention. Total cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C) cholesterol, glycated haemoglobin, fasting glucose, insulin, aspartate transaminase, alanine transaminase and different hormones and adipokines were analysed. Only VLDL-C (p = 0.01) and diastolic blood pressure (p = 0.027) decreased after the intervention, especially with the BG supplement. There were no other significant changes in the analysed biomarkers. In conclusion, the regular intake of GCP, BG and GCP/BG without lifestyle changes is not an efficient strategy to improve lipid and glucose homeostasis in overweight/obese subjects. |
author2 |
Ministerio de Economía y Competitividad (España) |
author_facet |
Ministerio de Economía y Competitividad (España) García-Cordero, Joaquín Mateos, Raquel González-Rámila, Susana Seguido, Miguel A. Sierra-Cinos, José Luis Sarriá, Beatriz Bravo, Laura |
format |
artículo |
topic_facet |
Oat beta-glucan Green coffee hydroxycinnamates Obesity Lipid metabolism Glucose homeostasis |
author |
García-Cordero, Joaquín Mateos, Raquel González-Rámila, Susana Seguido, Miguel A. Sierra-Cinos, José Luis Sarriá, Beatriz Bravo, Laura |
author_sort |
García-Cordero, Joaquín |
title |
Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention |
title_short |
Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention |
title_full |
Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention |
title_fullStr |
Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention |
title_full_unstemmed |
Dietary Supplements Containing Oat Beta-Glucan and/or Green Coffee (Poly)phenols Showed Limited Effect in Modulating Cardiometabolic Risk Biomarkers in Overweight/Obese Patients without a Lifestyle Intervention |
title_sort |
dietary supplements containing oat beta-glucan and/or green coffee (poly)phenols showed limited effect in modulating cardiometabolic risk biomarkers in overweight/obese patients without a lifestyle intervention |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023-05-08 |
url |
http://hdl.handle.net/10261/310509 |
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