Influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the PROFICEL study
[EN]: Introduction: It is known that the HLA genotype can explain about a 40% of the genetic risk of celiac disease (CD), thus, other genetic predisposing factors as well as factors that subtly modulate T cell activation and differentiation need to be studied. This includes environmental factors that are currently believed to impact on the immune system and gut microbiota development. Aim: To assess the associations between early environmental factors (EEF), lymphocyte subsets, and intestinal microbiota composition in infants at familial risk for CD. Study design: Prospective observational study. Subjects: Fifty-five 4 month-old infants with at least a first-degree relative suffering CD. Infants were classified according to type of delivery, mother's antibiotic intake during pregnancy and during labor, milk-feeding practices, early infections and antibiotic intake, rotavirus vaccine administration, and allergy incidence within the first 18 months of life. Methods: Lymphocyte subsets and gut microbiota composition were studied at the age of 4 months. Results: Formula feeding and infant's infections were associated with higher CD3+, CD4+, CD4+CD38+, CD4+CD28+ and CD3+CD4+CD45RO+ counts (P0.01). Infant s infections were also associated with higher CD4+CD25+, CD4+HLA-DR+ and NK cell counts (P0.01). Cesarean delivery and rotavirus vaccine administration were associated with lower percentage of CD4+CD25+ cells. Infant's antibiotic intake was associated and correlated with lower counts of Bifidobacterium longum and higher counts of Bacteroides fragilis group. Conclusions: Infant s infections and antibiotic intake in the first 4 months of life are the EEF more strongly and/or frequently associated to lymphocyte subpopulations and microbiota composition, respectively, in infants at risk of CD.
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Online Access: | http://hdl.handle.net/10261/242347 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100000780 |
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[EN]: Introduction: It is known that the HLA genotype can explain about a 40% of the genetic risk of celiac disease (CD), thus, other genetic predisposing factors as well as factors that subtly modulate T cell activation and differentiation need to be studied. This includes environmental factors that are currently believed to impact on the immune system and gut microbiota development.
Aim: To assess the associations between early environmental factors (EEF), lymphocyte subsets, and intestinal microbiota composition in infants at familial risk for CD.
Study design: Prospective observational study.
Subjects: Fifty-five 4 month-old infants with at least a first-degree relative suffering CD. Infants were classified according to type of delivery, mother's antibiotic intake during pregnancy and during labor, milk-feeding practices, early infections and antibiotic intake, rotavirus vaccine administration, and allergy incidence within the first 18 months of life.
Methods: Lymphocyte subsets and gut microbiota composition were studied at the age of 4 months.
Results: Formula feeding and infant's infections were associated with higher CD3+, CD4+, CD4+CD38+, CD4+CD28+ and CD3+CD4+CD45RO+ counts (P0.01). Infant s infections were also associated with higher CD4+CD25+, CD4+HLA-DR+ and NK cell counts (P0.01). Cesarean delivery and rotavirus vaccine administration were associated with lower percentage of CD4+CD25+ cells. Infant's antibiotic intake was associated and correlated with lower counts of Bifidobacterium longum and higher counts of Bacteroides fragilis group.
Conclusions: Infant s infections and antibiotic intake in the first 4 months of life are the EEF more strongly and/or frequently associated to lymphocyte subpopulations and microbiota composition, respectively, in infants at risk of CD. |
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Consejo Superior de Investigaciones Científicas (España) |
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Consejo Superior de Investigaciones Científicas (España) Pozo Rubio, Tamara Palma, Giada de Mujico, Jorge R. Olivares, Marta Marcos, Ascensión Acuña, M. Dolores Polanco, Isabel Sanz Herranz, Yolanda Nova, Esther |
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Pozo Rubio, Tamara Palma, Giada de Mujico, Jorge R. Olivares, Marta Marcos, Ascensión Acuña, M. Dolores Polanco, Isabel Sanz Herranz, Yolanda Nova, Esther |
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Pozo Rubio, Tamara Palma, Giada de Mujico, Jorge R. Olivares, Marta Marcos, Ascensión Acuña, M. Dolores Polanco, Isabel Sanz Herranz, Yolanda Nova, Esther Influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the PROFICEL study |
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Pozo Rubio, Tamara |
title |
Influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the PROFICEL study |
title_short |
Influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the PROFICEL study |
title_full |
Influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the PROFICEL study |
title_fullStr |
Influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the PROFICEL study |
title_full_unstemmed |
Influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the PROFICEL study |
title_sort |
influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the proficel study |
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Aran Ediciones |
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2021-06-02T12:09:02Z |
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http://hdl.handle.net/10261/242347 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100000780 |
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dig-ictan-es-10261-2423472021-06-22T12:50:43Z Influence of early environmental factors on lymphocyte subsets and gut microbiota in infants at risk of celiac disease; the PROFICEL study Influencia de factores ambientales tempranos sobre las subpoblaciones de linfocitos y la microbiota intestinal de niños con riesgo de desarrollar enfermedad celíaca; el Estudio PROFICEL Pozo Rubio, Tamara Palma, Giada de Mujico, Jorge R. Olivares, Marta Marcos, Ascensión Acuña, M. Dolores Polanco, Isabel Sanz Herranz, Yolanda Nova, Esther Consejo Superior de Investigaciones Científicas (España) European Commission Ministerio de Ciencia e Innovación (España) [EN]: Introduction: It is known that the HLA genotype can explain about a 40% of the genetic risk of celiac disease (CD), thus, other genetic predisposing factors as well as factors that subtly modulate T cell activation and differentiation need to be studied. This includes environmental factors that are currently believed to impact on the immune system and gut microbiota development. Aim: To assess the associations between early environmental factors (EEF), lymphocyte subsets, and intestinal microbiota composition in infants at familial risk for CD. Study design: Prospective observational study. Subjects: Fifty-five 4 month-old infants with at least a first-degree relative suffering CD. Infants were classified according to type of delivery, mother's antibiotic intake during pregnancy and during labor, milk-feeding practices, early infections and antibiotic intake, rotavirus vaccine administration, and allergy incidence within the first 18 months of life. Methods: Lymphocyte subsets and gut microbiota composition were studied at the age of 4 months. Results: Formula feeding and infant's infections were associated with higher CD3+, CD4+, CD4+CD38+, CD4+CD28+ and CD3+CD4+CD45RO+ counts (P0.01). Infant s infections were also associated with higher CD4+CD25+, CD4+HLA-DR+ and NK cell counts (P0.01). Cesarean delivery and rotavirus vaccine administration were associated with lower percentage of CD4+CD25+ cells. Infant's antibiotic intake was associated and correlated with lower counts of Bifidobacterium longum and higher counts of Bacteroides fragilis group. Conclusions: Infant s infections and antibiotic intake in the first 4 months of life are the EEF more strongly and/or frequently associated to lymphocyte subpopulations and microbiota composition, respectively, in infants at risk of CD. [ES]: Introducción: Es bien sabido que el genotipo HLA puede explicar un 40% del riesgo genético de enfermedad celíaca, por lo que otros factores de predisposición genéticos así como factores que sutilmente modulen la activación y diferenciación de células T necesitan ser estudiados. Esto incluye factores ambientales, de los que se cree actualmente que ejercen un efecto sobre el desarrollo del sistema inmune y la microbiota intestinal. Objetivo: Evaluar las asociaciones entre factores ambientales tempranos, las subpoblaciones de linfocitos y la composición de la microbiota intestinal en niños con riesgo familiar de enfermedad celíaca. Diseño del estudio: Estudio prospectivo observacional Sujetos: 55 niños de 4 meses de edad con al menos un familiar celíaco de primer grado. Los niños fueron clasificados de acuerdo al tipo de parto, ingesta materna de antibióticos durante el embarazo y durante el parto, tipo de lactancia, infecciones tempranas y toma de antibióticos, administración de la vacuna de rotavirus, y incidencia de alergias dentro de los 18 primeros meses de vida. Métodos: Las subpoblaciones de linfocitos y la composición de la microbiota intestinal fueron estudiadas a la edad de 4 meses. Resultados: La lactancia de fórmula y las infecciones tempranas se asociaron con un mayor número absoluto de células CD3+, CD4+, CD4+CD38+, CD4+CD28+ y CD3+CD4+ CD45RO+ (P0.01). El parto por cesárea y la administración de la vacuna de rotavirus se asociaron a un menor porcentaje de células CD4+CD25+. La toma temprana de antibióticos se asoció y correlacionó con menor número de Bifidobacterium longum y mayor número de Bacteroides fragilis. Conclusiones: Las infecciones y la toma de antibióticos en los primeros 4 meses de edad son los factores ambientales tempranos más fuertemente y/o frecuentemente asociados a las subpoblaciones de linfocitos y la composición de la microbiota, respectivamente, en niños con riesgo de enfermedad celíaca. Supported by grants AGL2007-66126-C03-01/ALI, AGL2007-66126-C03-02/ ALI and AGL2007-66126-C03-03/ALI, and Consolider Fun-C-Food CSD2007-00063, from the Spanish Ministry of Science and Innovation and grants 200570F0091 and 200570F0093 from CSIC. T. Pozo-Rubio, G. De Palma and M. Olivares are recipient of a personal grant from the JAE Program of CSIC (Spain) co-funded by European Social Fund. Peer reviewed 2021-06-02T12:09:02Z 2021-06-02T12:09:04Z 2021-06-02T12:09:02Z 2021-06-02T12:09:04Z 2013 artículo http://purl.org/coar/resource_type/c_6501 Nutricion Hospitalaria 28(2): 464-473 (2013) 0029-6651 http://hdl.handle.net/10261/242347 10.3305/nh.2013.28.2.6310 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100000780 en Publisher's version https://dx.doi.org/10.3305/nh.2013.28.2.6310 Sí open Aran Ediciones |