Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D
[Context and purpose]: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D.
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Springer Nature
2021
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dig-ictan-es-10261-2282042021-09-09T07:32:15Z Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D Cashman, Kevin D. Kiely, Mairead E. Andersen, Rikke Grønborg, Ida M. Madesn, Katja H. Nissen, Janna Tetens, Inge Tripkovic, Laura Lanham‑New, Susan A. Toxqui, Laura Vaquero, M. Pilar Trautvetter, Ulrike Jahreis, Gerhard Mistry, Vikram V. Specker, Bonny L. Hower, Jürgen Knoll, Anette Wagner, Dennis Vieth, Reinhold Öhlund, Inger Karlsland Åkeson, Pia Brett, Neil R. Weiler, Hope A. Ritz, Christian [Context and purpose]: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D. [Methods]: IPD analysis using data from 1429 participants (ages 2–89 years) in 11 RCTs with vitamin D-fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D DRV estimates across a range of serum 25(OH)D thresholds using unadjusted and adjusted models. [Results]: Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25 and ≥ 30 nmol/L are 6 and 12 µg/day, respectively (unadjusted model). The intake estimates to maintain 90%, 95% and 97.5% of concentrations ≥ 50 nmol/L are 33.4, 57.5 and 92.3 µg/day, respectively (unadjusted) and 17.0, 28.1 and 43.6 µg/day, respectively (adjusted for mean values for baseline serum 25(OH)D, age and BMI). [Conclusions]: IPD-derived vitamin D intakes required to maintain 90%, 95% and 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L are much higher than those derived from standard meta-regression based on aggregate data, due to the inability of the latter to capture between person-variability. Our IPD provides further evidence that using food-based approaches to achieve an intake of 12 µg/day could prevent vitamin D deficiency (i.e., serum 25(OH)D < 30 nmol/L) in the general population. Peer reviewed 2021-02-01T13:01:28Z 2021-02-01T13:01:28Z 2021 artículo http://purl.org/coar/resource_type/c_6501 European Journal of Nutrition 60: 939–959 (2021) 1436-6215 http://hdl.handle.net/10261/228204 10.1007/s00394-020-02298-x en Preprint https://doi.org/10.1007/s00394-020-02298-x Sí open Springer Nature |
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[Context and purpose]: Individual participant data-level meta-regression (IPD) analysis is superior to meta-regression based on aggregate data in determining Dietary Reference Values (DRV) for vitamin D. Using data from randomized controlled trials (RCTs) with vitamin D3-fortified foods, we undertook an IPD analysis of the response of winter serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among children and adults and derived DRV for vitamin D. |
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| author |
Cashman, Kevin D. Kiely, Mairead E. Andersen, Rikke Grønborg, Ida M. Madesn, Katja H. Nissen, Janna Tetens, Inge Tripkovic, Laura Lanham‑New, Susan A. Toxqui, Laura Vaquero, M. Pilar Trautvetter, Ulrike Jahreis, Gerhard Mistry, Vikram V. Specker, Bonny L. Hower, Jürgen Knoll, Anette Wagner, Dennis Vieth, Reinhold Öhlund, Inger Karlsland Åkeson, Pia Brett, Neil R. Weiler, Hope A. Ritz, Christian |
| spellingShingle |
Cashman, Kevin D. Kiely, Mairead E. Andersen, Rikke Grønborg, Ida M. Madesn, Katja H. Nissen, Janna Tetens, Inge Tripkovic, Laura Lanham‑New, Susan A. Toxqui, Laura Vaquero, M. Pilar Trautvetter, Ulrike Jahreis, Gerhard Mistry, Vikram V. Specker, Bonny L. Hower, Jürgen Knoll, Anette Wagner, Dennis Vieth, Reinhold Öhlund, Inger Karlsland Åkeson, Pia Brett, Neil R. Weiler, Hope A. Ritz, Christian Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D |
| author_facet |
Cashman, Kevin D. Kiely, Mairead E. Andersen, Rikke Grønborg, Ida M. Madesn, Katja H. Nissen, Janna Tetens, Inge Tripkovic, Laura Lanham‑New, Susan A. Toxqui, Laura Vaquero, M. Pilar Trautvetter, Ulrike Jahreis, Gerhard Mistry, Vikram V. Specker, Bonny L. Hower, Jürgen Knoll, Anette Wagner, Dennis Vieth, Reinhold Öhlund, Inger Karlsland Åkeson, Pia Brett, Neil R. Weiler, Hope A. Ritz, Christian |
| author_sort |
Cashman, Kevin D. |
| title |
Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D |
| title_short |
Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D |
| title_full |
Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D |
| title_fullStr |
Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D |
| title_full_unstemmed |
Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D |
| title_sort |
individual participant data (ipd)-level meta-analysis of randomised controlled trials with vitamin d-fortified foods to estimate dietary reference values for vitamin d |
| publisher |
Springer Nature |
| publishDate |
2021 |
| url |
http://hdl.handle.net/10261/228204 |
| work_keys_str_mv |
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