Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study
[Introduction]: Psychological and neuroendocrine alterations are typical characteristics in anorexia nervosa patients. The role of adipokines and cytokines as mediators of body systems’ adaptations to the patients’ abnormal eating behavior is not well understood. The duration of disease seems to be a determinant of nutritional status and associated hormone changes. We aimed to assess whether alterations in adipokines, cytokines and cortisol do already exist in patients with a recent disease onset by means of a case–control study.
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| Format: | artículo biblioteca |
| Language: | English |
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Elsevier España
2019
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| Subjects: | Anorexia nervosa, Adipokines, Cytokines, Cortisol, Case–control study, |
| Online Access: | http://hdl.handle.net/10261/203230 |
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dig-ictan-es-10261-2032302021-06-22T12:50:41Z Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study Alteraciones en adipoquinas, cortisol y citocinas en anorexia nerviosa de diagnóstico reciente. Estudio caso-control Elegido, Ana Gheorghe, Alina Sepúlveda, Ana Rosa Andrés, Patricia Díaz, L. E. Graell, Montserrat Marcos, Ascensión Nova, Esther Anorexia nervosa Adipokines Cytokines Cortisol Case–control study [Introduction]: Psychological and neuroendocrine alterations are typical characteristics in anorexia nervosa patients. The role of adipokines and cytokines as mediators of body systems’ adaptations to the patients’ abnormal eating behavior is not well understood. The duration of disease seems to be a determinant of nutritional status and associated hormone changes. We aimed to assess whether alterations in adipokines, cytokines and cortisol do already exist in patients with a recent disease onset by means of a case–control study. [Methods]: Forty-one adolescent female patients on their first-episode and diagnosed with anorexia nervosa, were matched by age and socioeconomic status (SES) (1:1) with healthy girls. Leptin, soluble leptin receptor (sOB-R), adiponectin, cortisol, and the cytokines IL-1β, IL-2, IL-6 and TNF-α were examined. [Results]: The results showed reduced leptin and increased sOB-R and cortisol levels in AN patients. Adiponectin was also increased but opposite to the previous biomarkers did not correlate with BMI Z-score. Serum TNF-α and IL-2 showed significantly lower and higher values, respectively, in the AN patients than in the controls. Cortisol showed the strongest correlation with sOB-R (r=0.436; P=0.005). [Conclusions]: Our study confirms previous findings on adipokine and cortisol alterations in AN patients, while overall cytokine results did not show a clear disruption in AN patients with short disease duration. The results highlight the need to disentangle the role of the sOB-R in the interactions between leptin and cortisol secretion. Peer reviewed 2020-03-09T12:24:01Z 2020-03-09T12:24:01Z 2019 artículo http://purl.org/coar/resource_type/c_6501 Endocrinología, Diabetes y Nutrición 66(9): 571-578 (2019) 2530-0172 http://hdl.handle.net/10261/203230 10.1016/j.endinu.2019.02.003 30981680 en Postprint https://doi.org/10.1016/j.endien.2019.10.004 Sí open Elsevier España |
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dig-ictan-es |
| tag |
biblioteca |
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| libraryname |
Biblioteca del ICTAN España |
| language |
English |
| topic |
Anorexia nervosa Adipokines Cytokines Cortisol Case–control study Anorexia nervosa Adipokines Cytokines Cortisol Case–control study |
| spellingShingle |
Anorexia nervosa Adipokines Cytokines Cortisol Case–control study Anorexia nervosa Adipokines Cytokines Cortisol Case–control study Elegido, Ana Gheorghe, Alina Sepúlveda, Ana Rosa Andrés, Patricia Díaz, L. E. Graell, Montserrat Marcos, Ascensión Nova, Esther Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study |
| description |
[Introduction]: Psychological and neuroendocrine alterations are typical characteristics in anorexia nervosa patients. The role of adipokines and cytokines as mediators of body systems’ adaptations to the patients’ abnormal eating behavior is not well understood. The duration of disease seems to be a determinant of nutritional status and associated hormone changes. We aimed to assess whether alterations in adipokines, cytokines and cortisol do already exist in patients with a recent disease onset by means of a case–control study. |
| format |
artículo |
| topic_facet |
Anorexia nervosa Adipokines Cytokines Cortisol Case–control study |
| author |
Elegido, Ana Gheorghe, Alina Sepúlveda, Ana Rosa Andrés, Patricia Díaz, L. E. Graell, Montserrat Marcos, Ascensión Nova, Esther |
| author_facet |
Elegido, Ana Gheorghe, Alina Sepúlveda, Ana Rosa Andrés, Patricia Díaz, L. E. Graell, Montserrat Marcos, Ascensión Nova, Esther |
| author_sort |
Elegido, Ana |
| title |
Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study |
| title_short |
Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study |
| title_full |
Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study |
| title_fullStr |
Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study |
| title_full_unstemmed |
Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study |
| title_sort |
adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. a case-control study |
| publisher |
Elsevier España |
| publishDate |
2019 |
| url |
http://hdl.handle.net/10261/203230 |
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