Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study
On behalf of the HELENA study group.
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Elsevier
2018
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| Online Access: | http://hdl.handle.net/10261/192593 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100003329 |
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dig-ictan-es-10261-1925932020-12-12T16:51:58Z Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study González-Gil, Esther Cadenas-Sanchez, Cristina Santabárbara, Javier Bueno, Gloria Iglesia, Iris González Gross, Marcela Molnár, Dénes Gottrand, Frederic De Henauw, Stefaan Cañada, David Censi, Laura Kersting, Mathilde Dallongeville, J. Marcos, Ascensión Ortega, F. B. Moreno, Luis A. Ministerio de Economía y Competitividad (España) Consejo Superior de Investigaciones Científicas (España) European Commission Stockholm County Council Ministerio de Ciencia e Innovación (España) On behalf of the HELENA study group. [Background and aims] Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. [Methods and results] A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. [Results] Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. [Conclusions] Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently. The HELENA Study was supported by the European Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034) and the Stockholm County Council. This analysis was also supported by the Spanish Ministry of Science and Innovation (JCI-2010-07055) and the gs4:European Regional Development Fund (FEDER). CCS is supported by the Spanish Ministry of Economy and Competitiveness (BES-2014-068829). FBO is supported by a grant from the Spanish Ministry of Science and Innovation (RYC-2011-09011). AIR was funded by a Juan de la Cierva-Formación stipend from the Ministry of Economy and Competitiveness of the Spanish Government (FJCI-2014-19795). Peer Reviewed 2019-10-14T11:27:23Z 2019-10-14T11:27:23Z 2018 2019-10-14T11:27:23Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.numecd.2017.10.004 e-issn: 1590-3729 issn: 0939-4753 Nutrition, Metabolism and Cardiovascular Diseases 28(1): 77-83 (2018) http://hdl.handle.net/10261/192593 10.1016/j.numecd.2017.10.004 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100003329 29174028 #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FJCI-2014-19795 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DEP2013-47540-R Postprint https://doi.org/10.1016/j.numecd.2017.10.004 Sí open Elsevier |
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On behalf of the HELENA study group. |
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Ministerio de Economía y Competitividad (España) |
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Ministerio de Economía y Competitividad (España) González-Gil, Esther Cadenas-Sanchez, Cristina Santabárbara, Javier Bueno, Gloria Iglesia, Iris González Gross, Marcela Molnár, Dénes Gottrand, Frederic De Henauw, Stefaan Cañada, David Censi, Laura Kersting, Mathilde Dallongeville, J. Marcos, Ascensión Ortega, F. B. Moreno, Luis A. |
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González-Gil, Esther Cadenas-Sanchez, Cristina Santabárbara, Javier Bueno, Gloria Iglesia, Iris González Gross, Marcela Molnár, Dénes Gottrand, Frederic De Henauw, Stefaan Cañada, David Censi, Laura Kersting, Mathilde Dallongeville, J. Marcos, Ascensión Ortega, F. B. Moreno, Luis A. |
| spellingShingle |
González-Gil, Esther Cadenas-Sanchez, Cristina Santabárbara, Javier Bueno, Gloria Iglesia, Iris González Gross, Marcela Molnár, Dénes Gottrand, Frederic De Henauw, Stefaan Cañada, David Censi, Laura Kersting, Mathilde Dallongeville, J. Marcos, Ascensión Ortega, F. B. Moreno, Luis A. Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study |
| author_sort |
González-Gil, Esther |
| title |
Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study |
| title_short |
Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study |
| title_full |
Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study |
| title_fullStr |
Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study |
| title_full_unstemmed |
Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study |
| title_sort |
inflammation in metabolically healthy and metabolically abnormal adolescents: the helena study |
| publisher |
Elsevier |
| publishDate |
2018 |
| url |
http://hdl.handle.net/10261/192593 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100003329 |
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1777670630840205312 |