Does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the HELENA study
Stress increases inflammation but whether adherence to Mediterranean diet counteracts this association and how early can these effects be observed is not well known. We tested whether (1) cortisol is associated to inflammation, (2) cortisol is associated to the adolescent Mediterranean diet score (aMDS), (3) aMDS lessens inflammation, (4) aMDS associates with cortisol levels and inflammation. Two hundred and forty-two adolescents (137 females; 12.5–17.5 years old) provided salivary cortisol, blood and 2-day 24-h dietary recall from which aMDS was derived. Cortisol levels were associated with increased tumor necrosis factor (TNF-α B = 11.887, p = 0.001) when adjusted for age, gender, parental education and body mass index (BMI). Moreover, cortisol levels were inversely associated to adherence to the Mediterranean Diet (B = −1.023, p = 0.002). Adolescents with higher adherence to aMDS had lower levels of interleukins (IL) IL-1, IL-2, IL-6 and TNF-α, compared to those who did not adhere. The association between cortisol and TNF-α was no longer significant when aMDS was included in the model (B = 6.118, p = 0.139). In addition, comparing lower and higher aMDS groups, the association between cortisol and TNF-α was only observed in those with lower aMDS adherence. Our study suggests that adherence to the Mediterranean Diet may counteract the effect of stress on inflammatory biomarkers which may contribute to decreasing the risk of future mental health.
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Multidisciplinary Digital Publishing Institute
2018-11-15
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Subjects: | Diet quality, Depressive symptoms, Risk factors, Epidemiology, Immune system, Prevention, Hypothalamic–pituitary–adrenal-HPA axis, |
Online Access: | http://hdl.handle.net/10261/172557 http://dx.doi.org/10.13039/100004330 http://dx.doi.org/10.13039/501100000735 http://dx.doi.org/10.13039/501100000765 http://dx.doi.org/10.13039/501100000265 http://dx.doi.org/10.13039/501100002322 http://dx.doi.org/10.13039/100005205 |
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dig-ictan-es-10261-1725572021-12-27T16:14:39Z Does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the HELENA study Carvalho, Kenia M. B. Ronca, Débora B. Michels, Nathalie Huybrechts, Inge Cuenca-García, Magdalena Marcos, Ascensión Molnár, Dénes Dallongeville, J. Manios, Yannis Schaan, Beatriz D. Moreno, Luis A. De Henauw, Stefaan Carvalho, Livia A. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil) Medical Research Council (UK) University of Cambridge University College London GlaxoSmithKline Janssen Research and Development Diet quality Depressive symptoms Risk factors Epidemiology Immune system Prevention Hypothalamic–pituitary–adrenal-HPA axis Stress increases inflammation but whether adherence to Mediterranean diet counteracts this association and how early can these effects be observed is not well known. We tested whether (1) cortisol is associated to inflammation, (2) cortisol is associated to the adolescent Mediterranean diet score (aMDS), (3) aMDS lessens inflammation, (4) aMDS associates with cortisol levels and inflammation. Two hundred and forty-two adolescents (137 females; 12.5–17.5 years old) provided salivary cortisol, blood and 2-day 24-h dietary recall from which aMDS was derived. Cortisol levels were associated with increased tumor necrosis factor (TNF-α B = 11.887, p = 0.001) when adjusted for age, gender, parental education and body mass index (BMI). Moreover, cortisol levels were inversely associated to adherence to the Mediterranean Diet (B = −1.023, p = 0.002). Adolescents with higher adherence to aMDS had lower levels of interleukins (IL) IL-1, IL-2, IL-6 and TNF-α, compared to those who did not adhere. The association between cortisol and TNF-α was no longer significant when aMDS was included in the model (B = 6.118, p = 0.139). In addition, comparing lower and higher aMDS groups, the association between cortisol and TNF-α was only observed in those with lower aMDS adherence. Our study suggests that adherence to the Mediterranean Diet may counteract the effect of stress on inflammatory biomarkers which may contribute to decreasing the risk of future mental health. This work funded by CAPES—Brazilian Federal Agency for Support and Evaluation of Graduate Education within the Ministry of Education of Brazil to KMBC. This study was also funded by the Medical Research Council (UK) Immuno-Psychiatry Consortium grant awarded to University of Cambridge, University College London with industrial partnership funding from GlaxoSmithKline (GSK) and Janssen. Peer reviewed 2018-11-22T14:23:43Z 2018-11-22T14:23:43Z 2018-11-15 2018-11-22T14:23:43Z artículo http://purl.org/coar/resource_type/c_6501 Nutrients 10(11): 1770 (2018) http://hdl.handle.net/10261/172557 10.3390/nu10111770 2072-6643 http://dx.doi.org/10.13039/100004330 http://dx.doi.org/10.13039/501100000735 http://dx.doi.org/10.13039/501100000765 http://dx.doi.org/10.13039/501100000265 http://dx.doi.org/10.13039/501100002322 http://dx.doi.org/10.13039/100005205 30445703 Publisher's version http://dx.doi.org/10.3390/nu10111770 Sí open Multidisciplinary Digital Publishing Institute |
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Diet quality Depressive symptoms Risk factors Epidemiology Immune system Prevention Hypothalamic–pituitary–adrenal-HPA axis Diet quality Depressive symptoms Risk factors Epidemiology Immune system Prevention Hypothalamic–pituitary–adrenal-HPA axis |
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Diet quality Depressive symptoms Risk factors Epidemiology Immune system Prevention Hypothalamic–pituitary–adrenal-HPA axis Diet quality Depressive symptoms Risk factors Epidemiology Immune system Prevention Hypothalamic–pituitary–adrenal-HPA axis Carvalho, Kenia M. B. Ronca, Débora B. Michels, Nathalie Huybrechts, Inge Cuenca-García, Magdalena Marcos, Ascensión Molnár, Dénes Dallongeville, J. Manios, Yannis Schaan, Beatriz D. Moreno, Luis A. De Henauw, Stefaan Carvalho, Livia A. Does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the HELENA study |
description |
Stress increases inflammation but whether adherence to Mediterranean diet counteracts this association and how early can these effects be observed is not well known. We tested whether (1) cortisol is associated to inflammation, (2) cortisol is associated to the adolescent Mediterranean diet score (aMDS), (3) aMDS lessens inflammation, (4) aMDS associates with cortisol levels and inflammation. Two hundred and forty-two adolescents (137 females; 12.5–17.5 years old) provided salivary cortisol, blood and 2-day 24-h dietary recall from which aMDS was derived. Cortisol levels were associated with increased tumor necrosis factor (TNF-α B = 11.887, p = 0.001) when adjusted for age, gender, parental education and body mass index (BMI). Moreover, cortisol levels were inversely associated to adherence to the Mediterranean Diet (B = −1.023, p = 0.002). Adolescents with higher adherence to aMDS had lower levels of interleukins (IL) IL-1, IL-2, IL-6 and TNF-α, compared to those who did not adhere. The association between cortisol and TNF-α was no longer significant when aMDS was included in the model (B = 6.118, p = 0.139). In addition, comparing lower and higher aMDS groups, the association between cortisol and TNF-α was only observed in those with lower aMDS adherence. Our study suggests that adherence to the Mediterranean Diet may counteract the effect of stress on inflammatory biomarkers which may contribute to decreasing the risk of future mental health. |
author2 |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil) |
author_facet |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil) Carvalho, Kenia M. B. Ronca, Débora B. Michels, Nathalie Huybrechts, Inge Cuenca-García, Magdalena Marcos, Ascensión Molnár, Dénes Dallongeville, J. Manios, Yannis Schaan, Beatriz D. Moreno, Luis A. De Henauw, Stefaan Carvalho, Livia A. |
format |
artículo |
topic_facet |
Diet quality Depressive symptoms Risk factors Epidemiology Immune system Prevention Hypothalamic–pituitary–adrenal-HPA axis |
author |
Carvalho, Kenia M. B. Ronca, Débora B. Michels, Nathalie Huybrechts, Inge Cuenca-García, Magdalena Marcos, Ascensión Molnár, Dénes Dallongeville, J. Manios, Yannis Schaan, Beatriz D. Moreno, Luis A. De Henauw, Stefaan Carvalho, Livia A. |
author_sort |
Carvalho, Kenia M. B. |
title |
Does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the HELENA study |
title_short |
Does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the HELENA study |
title_full |
Does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the HELENA study |
title_fullStr |
Does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the HELENA study |
title_full_unstemmed |
Does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the HELENA study |
title_sort |
does the mediterranean diet protect against stress-induced inflammatory activation in european adolescents? the helena study |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2018-11-15 |
url |
http://hdl.handle.net/10261/172557 http://dx.doi.org/10.13039/100004330 http://dx.doi.org/10.13039/501100000735 http://dx.doi.org/10.13039/501100000765 http://dx.doi.org/10.13039/501100000265 http://dx.doi.org/10.13039/501100002322 http://dx.doi.org/10.13039/100005205 |
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