Cardiovascular disease markers responses in male receiving improved-fat meat products vary by initial LDL-cholesterol levels

[EN]: Objectives: Cardiovascular disease (CVD) is prevalent in peoples at high meat-product consumption. To study the effect of consuming different Pâté and Frankfurter formulations on clinical/emergent CVD biomarkers in male volunteers with different initial LDL-cholesterol levels (< and ³ 3.36 mmol/L).Method: Eighteen male volunteers with at least two CVD risk factors were enrolled in a sequentially controlled study. Pork-products were consumed during 4wk: reduced-fat (RF), omega-3-enriched-RF (n-3RF), and normal-fat (NF). Pork-products were separated by 4wk washout. Lipids, lipoproteins, oxidized LDL (oxLDL), apolipoproteins (apo) and their ratios, homocysteine (tHcys), arylesterase (AE), C-reactive protein (CRP), tumor necrotic factor (TNFa) were tested.Results: The rate of change for AE, oxLDL, Lp(a), AE/HDL-cholesterol, LDL/apo B and AE/oxLDL ratios varied (p<0.05) among periods only in volunteers with LDL-cholesterol ³3.36 mmol/L. TNFa decreased (p<0.05) among volunteers with low-normal LDL-cholesterol values while AE increased (p<0.01) in high LDL-cholesterol volunteers during the RF-period. AE increased while CRP decreased (both p<0.01) in low-normal LDL-cholesterol volunteers while AE (p<0.001) and apo B (p<0.01) increased in the high LDL-cholesterol group during the n-3RF-period. Total cholesterol (p<0.05) increased in the low/normal LDL-cholesterol group while tHcys decreased (p<0.05) in the high LDL-cholesterol group during the NF-period. Differences in response in volunteers with low-normal vs. high initial LDL-cholesterol levels to the n-3RF but not to the RF meat-products were evident.Conclusions: Subjects with high LDL-cholesterol seems target for n-3RF products while subjects with LDL-cholesterol <3.36 mmol/L were more negatively affected by NF-products. Any generalization about functional meat product or consumption should be avoided.

Bibliographic Details

Main Authors:	Celada, Paloma, Sánchez-Muniz, F. J., Delgado Pando, Gonzalo, Bastida, Sara, Espárrago-Rodilla, Manuel, Jiménez Colmenero, Francisco, Olmedilla Alonso, Begoña
Other Authors:	Ministerio de Economía y Competitividad (España)
Format:	artículo biblioteca
Published:	Asociación Para el Progreso de la Biomedicina 2016
Subjects:	LDL-colesterol, CVD risk markers, Frankfurters, Pâtes, Low fat, Omega-3, Pork, High-CVD risk-subjects, Alto riesgo cardiovascular, Bajo-en-grasa, Patés, Cerdo salchichas tipo Frankfurt, Marcadores de riesgo, LDL-cholesterol,
Online Access:	http://hdl.handle.net/10261/171511 http://dx.doi.org/10.13039/501100003329
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