Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients
Anorexia nervosa (AN) is an atypical form of malnutrition with peculiar changes in the immune system. We hypothesized that different lymphocyte subsets are differentially affected by malnutrition in AN, and thus, our aim was to investigate the influence of body mass loss on the variability of lymphocyte subsets in AN patients. A group of 66 adolescent female patients, aged 12-17 years, referred for their first episode of either AN or feeding or eating disorders not elsewhere classified were studied upon admission (46 AN-restricting subtype, 11 AN-binge/purging subtype, and 9 feeding or eating disorders not elsewhere classified). Ninety healthy adolescents served as controls. White blood cells and lymphocyte subsets were analyzed by flow cytometry. Relationships with the body mass index (BMI) z score were assessed in linear models adjusted by diagnostic subtype and age. Leukocyte numbers were lower in AN patients than in controls, and relative lymphocytosis was observed in AN-restricting subtype. Lower CD8, NK, and memory CD8 counts were found in eating disorder patients compared with controls. No differences were found for CD4 counts or naive and memory CD4 subsets between the groups. Negative associations between lymphocyte percentage and the BMI z score, as well as between the B cell counts, naive CD4 percentage and counts, and the BMI z score, were found. In conclusion, increased naive CD4 and B lymphocyte subsets associated with body mass loss drive the relative lymphocytosis observed in AN patients, which reflects an adaptive mechanism to preserve the adaptive immune response.
Main Authors: | , , , , , |
---|---|
Other Authors: | |
Format: | artículo biblioteca |
Published: |
Elsevier
2017
|
Subjects: | White blood cells, Lymphocyte subsets, Body mass loss, Anorexia nervosa, Relative lymphocytosis, |
Online Access: | http://hdl.handle.net/10261/171384 http://dx.doi.org/10.13039/100008062 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-ictan-es-10261-171384 |
---|---|
record_format |
koha |
spelling |
dig-ictan-es-10261-1713842021-06-22T12:50:43Z Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients Elegido, Ana Graell, Montserrat Andrés, Patricia Gheorghe, Alina Marcos, Ascensión Nova, Esther Fundación Alicia Koplowitz Ministerio de Sanidad y Consumo (España) White blood cells Lymphocyte subsets Body mass loss Anorexia nervosa Relative lymphocytosis Anorexia nervosa (AN) is an atypical form of malnutrition with peculiar changes in the immune system. We hypothesized that different lymphocyte subsets are differentially affected by malnutrition in AN, and thus, our aim was to investigate the influence of body mass loss on the variability of lymphocyte subsets in AN patients. A group of 66 adolescent female patients, aged 12-17 years, referred for their first episode of either AN or feeding or eating disorders not elsewhere classified were studied upon admission (46 AN-restricting subtype, 11 AN-binge/purging subtype, and 9 feeding or eating disorders not elsewhere classified). Ninety healthy adolescents served as controls. White blood cells and lymphocyte subsets were analyzed by flow cytometry. Relationships with the body mass index (BMI) z score were assessed in linear models adjusted by diagnostic subtype and age. Leukocyte numbers were lower in AN patients than in controls, and relative lymphocytosis was observed in AN-restricting subtype. Lower CD8, NK, and memory CD8 counts were found in eating disorder patients compared with controls. No differences were found for CD4 counts or naive and memory CD4 subsets between the groups. Negative associations between lymphocyte percentage and the BMI z score, as well as between the B cell counts, naive CD4 percentage and counts, and the BMI z score, were found. In conclusion, increased naive CD4 and B lymphocyte subsets associated with body mass loss drive the relative lymphocytosis observed in AN patients, which reflects an adaptive mechanism to preserve the adaptive immune response. This work was supported by the Ministry of Health (FIS PI08/1832) and Alicia Koplowitz Foundation (2009). Peer Reviewed 2018-10-23T07:26:20Z 2018-10-23T07:26:20Z 2017 2018-10-23T07:26:20Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.nutres.2017.02.006 e-issn: 1879-0739 issn: 0271-5317 Nutrition Research 39: 43-50 (2017) http://hdl.handle.net/10261/171384 10.1016/j.nutres.2017.02.006 http://dx.doi.org/10.13039/100008062 28385288 Postprint https://doi.org/10.1016/j.nutres.2017.02.006 Sí open Elsevier |
institution |
ICTAN ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-ictan-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del ICTAN España |
topic |
White blood cells Lymphocyte subsets Body mass loss Anorexia nervosa Relative lymphocytosis White blood cells Lymphocyte subsets Body mass loss Anorexia nervosa Relative lymphocytosis |
spellingShingle |
White blood cells Lymphocyte subsets Body mass loss Anorexia nervosa Relative lymphocytosis White blood cells Lymphocyte subsets Body mass loss Anorexia nervosa Relative lymphocytosis Elegido, Ana Graell, Montserrat Andrés, Patricia Gheorghe, Alina Marcos, Ascensión Nova, Esther Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients |
description |
Anorexia nervosa (AN) is an atypical form of malnutrition with peculiar changes in the immune system. We hypothesized that different lymphocyte subsets are differentially affected by malnutrition in AN, and thus, our aim was to investigate the influence of body mass loss on the variability of lymphocyte subsets in AN patients. A group of 66 adolescent female patients, aged 12-17 years, referred for their first episode of either AN or feeding or eating disorders not elsewhere classified were studied upon admission (46 AN-restricting subtype, 11 AN-binge/purging subtype, and 9 feeding or eating disorders not elsewhere classified). Ninety healthy adolescents served as controls. White blood cells and lymphocyte subsets were analyzed by flow cytometry. Relationships with the body mass index (BMI) z score were assessed in linear models adjusted by diagnostic subtype and age. Leukocyte numbers were lower in AN patients than in controls, and relative lymphocytosis was observed in AN-restricting subtype. Lower CD8, NK, and memory CD8 counts were found in eating disorder patients compared with controls. No differences were found for CD4 counts or naive and memory CD4 subsets between the groups. Negative associations between lymphocyte percentage and the BMI z score, as well as between the B cell counts, naive CD4 percentage and counts, and the BMI z score, were found. In conclusion, increased naive CD4 and B lymphocyte subsets associated with body mass loss drive the relative lymphocytosis observed in AN patients, which reflects an adaptive mechanism to preserve the adaptive immune response. |
author2 |
Fundación Alicia Koplowitz |
author_facet |
Fundación Alicia Koplowitz Elegido, Ana Graell, Montserrat Andrés, Patricia Gheorghe, Alina Marcos, Ascensión Nova, Esther |
format |
artículo |
topic_facet |
White blood cells Lymphocyte subsets Body mass loss Anorexia nervosa Relative lymphocytosis |
author |
Elegido, Ana Graell, Montserrat Andrés, Patricia Gheorghe, Alina Marcos, Ascensión Nova, Esther |
author_sort |
Elegido, Ana |
title |
Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients |
title_short |
Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients |
title_full |
Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients |
title_fullStr |
Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients |
title_full_unstemmed |
Increased naive CD4+ and B lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients |
title_sort |
increased naive cd4+ and b lymphocyte subsets are associated with body mass loss and drive relative lymphocytosis in anorexia nervosa patients |
publisher |
Elsevier |
publishDate |
2017 |
url |
http://hdl.handle.net/10261/171384 http://dx.doi.org/10.13039/100008062 |
work_keys_str_mv |
AT elegidoana increasednaivecd4andblymphocytesubsetsareassociatedwithbodymasslossanddriverelativelymphocytosisinanorexianervosapatients AT graellmontserrat increasednaivecd4andblymphocytesubsetsareassociatedwithbodymasslossanddriverelativelymphocytosisinanorexianervosapatients AT andrespatricia increasednaivecd4andblymphocytesubsetsareassociatedwithbodymasslossanddriverelativelymphocytosisinanorexianervosapatients AT gheorghealina increasednaivecd4andblymphocytesubsetsareassociatedwithbodymasslossanddriverelativelymphocytosisinanorexianervosapatients AT marcosascension increasednaivecd4andblymphocytesubsetsareassociatedwithbodymasslossanddriverelativelymphocytosisinanorexianervosapatients AT novaesther increasednaivecd4andblymphocytesubsetsareassociatedwithbodymasslossanddriverelativelymphocytosisinanorexianervosapatients |
_version_ |
1777670576818618368 |