Metabolomic fingerprinting in the comprehensive study of liver changes associated with onion supplementation in hypercholesterolemic wistar rats
The consumption of functional ingredients has been suggested to be a complementary tool for the prevention and management of liver disease. In this light, processed onion can be considered as a source of multiple bioactive compounds with hepatoprotective properties. The liver fingerprint of male Wistar rats (<i>n</i> = 24) fed with three experimental diets (control (C), high-cholesterol (HC), and high-cholesterol enriched with onion (HCO) diets) was obtained through a non-targeted, multiplatform metabolomics approach to produce broad metabolite coverage. LC-MS, CE-MS and GC-MS results were subjected to univariate and multivariate analyses, providing a list of significant metabolites. All data were merged in order to figure out the most relevant metabolites that were modified by the onion ingredient. Several relevant metabolic changes and related metabolic pathways were found to be impacted by both HC and HCO diet. The model highlighted several metabolites (such as hydroxybutyryl carnitine and palmitoyl carnitine) modified by the HCO diet. These findings could suggest potential impairments in the energy−lipid metabolism, perturbations in the tricarboxylic acid cycle (TCA) cycle and β-oxidation modulated by the onion supplementation in the core of hepatic dysfunction. Metabolomics shows to be a valuable tool to evaluate the effects of complementary dietetic approaches directed to hepatic damage amelioration or non-alcoholic fatty liver disease (NAFLD) prevention.
Main Authors: | González Peña, Diana, Dudzik, Danuta, García, Antonia, Ancos, Begoña de, Barbas, Coral, Sánchez-Moreno, Concepción |
---|---|
Other Authors: | Ministerio de Ciencia e Innovación (España) |
Format: | artículo biblioteca |
Published: |
Multidisciplinary Digital Publishing Institute
2017-01-28
|
Online Access: | http://hdl.handle.net/10261/149347 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Metabolomics fingerprinting of liver in the comprehensive evaluation of onion as a functional ingredient in the prevention of metabolic impairments associated to diet-induced hypercholesterolaemia
by: Dudzik, Danuta, et al.
Published: (2017) -
Multiplatform metabolomic fingerprinting as a tool for understanding hypercholesterolemia in Wistar rats
by: González Peña, Diana, et al.
Published: (2016) -
Positive effects on lipid metabolism in Wistar rats of hypercholesterolemic diets enhanced by onion intake
by: Colina Coca, Clara, et al.
Published: (2014) -
Positive effects on lipid metabolism in Wistar rats of hypercholesterolemic diets enhanced by onion intake
by: Colina Coca, Clara, et al.
Published: (2014) -
Dietary onion ameliorates antioxidant defence, inflammatory response, and cardiovascular risk biomarkers in hypercholesterolemic Wistar rats
by: Colina Coca, Clara, et al.
Published: (2017)