Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study.
BACKGROUND: Sleep patterns face important changes during adolescence. This can have implications for the immune system, which is regulated by the sleep-wake cycle; however, most studies relating sleep and immune system have been conducted on adults. OBJECTIVE: To study the relationships between sleep duration, immune cell counts, and cytokines in European adolescents participating in the HELENA Cross-Sectional Study. METHODS: Adolescents (12.5-17.5¿years; n¿=¿933; 53.9% girls) were grouped according to self-reported sleep duration into <8, 8-8.9 and ¿9¿h/night. Blood samples were collected in the morning after an overnight fast to analyze counts of white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, basophils, the lymphocyte subsets CD3(+), CD4(+), CD8(+), CD45RA(+), CD45RO(+), CD3(-)CD16(+)56(+) and CD19(+), and concentrations of cortisol, CRP, IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, TNF-¿ and IFN-¿. Pro-/anti-inflammatory and Th1/Th2 cytokine ratios were calculated. Immune parameters were correlated to sleep duration and compared between the three groups. RESULTS: Sleep duration was negatively associated with cortisol levels and WBC, neutrophil, monocyte, CD4(+) and CD4(+)CD45RO(+) counts; in girls it is also negatively associated with IL-5 and IL-6 levels. The 8-8.9¿h/night group presented the highest IL-4 values and the lowest pro-/anti-inflammatory and Th1/Th2 cytokine ratios. CONCLUSION: A sleep duration of 8-8.9¿h/night was associated with a healthier immune profile in our adolescents.
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Elsevier
2014
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Subjects: | Cytokine balance, Sleep duration, Immune cell profile, Inflammation, Th1/Th2, Adolescents, Gender differences, |
Online Access: | http://hdl.handle.net/10261/111436 |
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dig-ictan-es-10261-1114362016-12-23T11:57:00Z Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. Pérez de Heredia, F. Gómez Martínez, Sonia Díaz, L. E. Marcos, Ascensión Cytokine balance Sleep duration Immune cell profile Inflammation Th1/Th2 Adolescents Gender differences BACKGROUND: Sleep patterns face important changes during adolescence. This can have implications for the immune system, which is regulated by the sleep-wake cycle; however, most studies relating sleep and immune system have been conducted on adults. OBJECTIVE: To study the relationships between sleep duration, immune cell counts, and cytokines in European adolescents participating in the HELENA Cross-Sectional Study. METHODS: Adolescents (12.5-17.5¿years; n¿=¿933; 53.9% girls) were grouped according to self-reported sleep duration into <8, 8-8.9 and ¿9¿h/night. Blood samples were collected in the morning after an overnight fast to analyze counts of white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, basophils, the lymphocyte subsets CD3(+), CD4(+), CD8(+), CD45RA(+), CD45RO(+), CD3(-)CD16(+)56(+) and CD19(+), and concentrations of cortisol, CRP, IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, TNF-¿ and IFN-¿. Pro-/anti-inflammatory and Th1/Th2 cytokine ratios were calculated. Immune parameters were correlated to sleep duration and compared between the three groups. RESULTS: Sleep duration was negatively associated with cortisol levels and WBC, neutrophil, monocyte, CD4(+) and CD4(+)CD45RO(+) counts; in girls it is also negatively associated with IL-5 and IL-6 levels. The 8-8.9¿h/night group presented the highest IL-4 values and the lowest pro-/anti-inflammatory and Th1/Th2 cytokine ratios. CONCLUSION: A sleep duration of 8-8.9¿h/night was associated with a healthier immune profile in our adolescents. Peer Reviewed 2015-02-27T07:14:16Z 2015-02-27T07:14:16Z 2014 2015-02-27T07:14:16Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.sleep.2014.04.010 issn: 1389-9457 Sleep Medicine 15: 1251- 1258 (2014) http://hdl.handle.net/10261/111436 10.1016/j.sleep.2014.04.010 none Elsevier |
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Cytokine balance Sleep duration Immune cell profile Inflammation Th1/Th2 Adolescents Gender differences Cytokine balance Sleep duration Immune cell profile Inflammation Th1/Th2 Adolescents Gender differences |
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Cytokine balance Sleep duration Immune cell profile Inflammation Th1/Th2 Adolescents Gender differences Cytokine balance Sleep duration Immune cell profile Inflammation Th1/Th2 Adolescents Gender differences Pérez de Heredia, F. Gómez Martínez, Sonia Díaz, L. E. Marcos, Ascensión Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. |
description |
BACKGROUND: Sleep patterns face important changes during adolescence. This can have implications for the immune system, which is regulated by the sleep-wake cycle; however, most studies relating sleep and immune system have been conducted on adults. OBJECTIVE: To study the relationships between sleep duration, immune cell counts, and cytokines in European adolescents participating in the HELENA Cross-Sectional Study. METHODS: Adolescents (12.5-17.5¿years; n¿=¿933; 53.9% girls) were grouped according to self-reported sleep duration into <8, 8-8.9 and ¿9¿h/night. Blood samples were collected in the morning after an overnight fast to analyze counts of white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, basophils, the lymphocyte subsets CD3(+), CD4(+), CD8(+), CD45RA(+), CD45RO(+), CD3(-)CD16(+)56(+) and CD19(+), and concentrations of cortisol, CRP, IL-1, IL-2, IL-4, IL-5, IL-6, IL-10, TNF-¿ and IFN-¿. Pro-/anti-inflammatory and Th1/Th2 cytokine ratios were calculated. Immune parameters were correlated to sleep duration and compared between the three groups. RESULTS: Sleep duration was negatively associated with cortisol levels and WBC, neutrophil, monocyte, CD4(+) and CD4(+)CD45RO(+) counts; in girls it is also negatively associated with IL-5 and IL-6 levels. The 8-8.9¿h/night group presented the highest IL-4 values and the lowest pro-/anti-inflammatory and Th1/Th2 cytokine ratios. CONCLUSION: A sleep duration of 8-8.9¿h/night was associated with a healthier immune profile in our adolescents. |
format |
artículo |
topic_facet |
Cytokine balance Sleep duration Immune cell profile Inflammation Th1/Th2 Adolescents Gender differences |
author |
Pérez de Heredia, F. Gómez Martínez, Sonia Díaz, L. E. Marcos, Ascensión |
author_facet |
Pérez de Heredia, F. Gómez Martínez, Sonia Díaz, L. E. Marcos, Ascensión |
author_sort |
Pérez de Heredia, F. |
title |
Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. |
title_short |
Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. |
title_full |
Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. |
title_fullStr |
Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. |
title_full_unstemmed |
Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study. |
title_sort |
self-reported sleep duration, white blood cell counts and cytokine profiles in european adolescents: the helena study. |
publisher |
Elsevier |
publishDate |
2014 |
url |
http://hdl.handle.net/10261/111436 |
work_keys_str_mv |
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