Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins
Anthocyanins are the main group of natural hydrosoluble pigments in plants. They introduce colouring to foods, with colours ranging from blue to red and orange. Nowadays, their importance for the Food and Pharmaceutical industries is mainly based in the existing scientific work evidencing their beneficial effects on the prevention of cardiovascular diseases and neurological conditions. Different mechanisms have been shown to be involved in those effects. The most consistent ones are related to their antihypertensive and endothelium protective activities, antiatherogenic activity and their interaction with the estrogenic receptor. In some of the existing work, studies on structure-activity relationship have been done, showing that modifications on the structure of anthocyanins, besides having an effect on their colours, have a clear incidence on their interaction with different steps in the principal pathways related to these diseases. Therefore, different colours might show different molecular mechanisms. However, in a normal diet most of these compounds are present simultaneously and, thus; they can act by different mechanisms but can rise to a common final action. Design of new food product or food supplements should take these potential synergies into consideration. © 2014 Elsevier Inc. All rights reserved.
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Elsevier
2014
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Subjects: | Neuroprotection, Cardiovascular, Anthocyanins, Molecular mechanisms, |
Online Access: | http://hdl.handle.net/10261/103121 |
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dig-ictan-es-10261-1031212021-06-30T10:52:38Z Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins Pascual-Teresa, Sonia de Neuroprotection Cardiovascular Anthocyanins Molecular mechanisms Anthocyanins are the main group of natural hydrosoluble pigments in plants. They introduce colouring to foods, with colours ranging from blue to red and orange. Nowadays, their importance for the Food and Pharmaceutical industries is mainly based in the existing scientific work evidencing their beneficial effects on the prevention of cardiovascular diseases and neurological conditions. Different mechanisms have been shown to be involved in those effects. The most consistent ones are related to their antihypertensive and endothelium protective activities, antiatherogenic activity and their interaction with the estrogenic receptor. In some of the existing work, studies on structure-activity relationship have been done, showing that modifications on the structure of anthocyanins, besides having an effect on their colours, have a clear incidence on their interaction with different steps in the principal pathways related to these diseases. Therefore, different colours might show different molecular mechanisms. However, in a normal diet most of these compounds are present simultaneously and, thus; they can act by different mechanisms but can rise to a common final action. Design of new food product or food supplements should take these potential synergies into consideration. © 2014 Elsevier Inc. All rights reserved. Part of this work was supported by the Spanish Ministry of Economy and Competitiveness (AGL2012-30803) and CSIC (i-link0502). Peer Reviewed 2014-10-09T13:22:31Z 2014-10-09T13:22:31Z 2014 2014-10-09T13:22:31Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.abb.2014.04.012 issn: 1096-0384 Archives of Biochemistry and Biophysics 559: 68- 74 (2014) http://hdl.handle.net/10261/103121 10.1016/j.abb.2014.04.012 none Elsevier |
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Neuroprotection Cardiovascular Anthocyanins Molecular mechanisms Neuroprotection Cardiovascular Anthocyanins Molecular mechanisms |
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Neuroprotection Cardiovascular Anthocyanins Molecular mechanisms Neuroprotection Cardiovascular Anthocyanins Molecular mechanisms Pascual-Teresa, Sonia de Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins |
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Anthocyanins are the main group of natural hydrosoluble pigments in plants. They introduce colouring to foods, with colours ranging from blue to red and orange. Nowadays, their importance for the Food and Pharmaceutical industries is mainly based in the existing scientific work evidencing their beneficial effects on the prevention of cardiovascular diseases and neurological conditions. Different mechanisms have been shown to be involved in those effects. The most consistent ones are related to their antihypertensive and endothelium protective activities, antiatherogenic activity and their interaction with the estrogenic receptor. In some of the existing work, studies on structure-activity relationship have been done, showing that modifications on the structure of anthocyanins, besides having an effect on their colours, have a clear incidence on their interaction with different steps in the principal pathways related to these diseases. Therefore, different colours might show different molecular mechanisms. However, in a normal diet most of these compounds are present simultaneously and, thus; they can act by different mechanisms but can rise to a common final action. Design of new food product or food supplements should take these potential synergies into consideration. © 2014 Elsevier Inc. All rights reserved. |
format |
artículo |
topic_facet |
Neuroprotection Cardiovascular Anthocyanins Molecular mechanisms |
author |
Pascual-Teresa, Sonia de |
author_facet |
Pascual-Teresa, Sonia de |
author_sort |
Pascual-Teresa, Sonia de |
title |
Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins |
title_short |
Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins |
title_full |
Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins |
title_fullStr |
Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins |
title_full_unstemmed |
Molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins |
title_sort |
molecular mechanisms involved in the cardiovascular and neuroprotective effects of anthocyanins |
publisher |
Elsevier |
publishDate |
2014 |
url |
http://hdl.handle.net/10261/103121 |
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AT pascualteresasoniade molecularmechanismsinvolvedinthecardiovascularandneuroprotectiveeffectsofanthocyanins |
_version_ |
1777670487136010240 |