Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy
The edible fruits of Myrciaria vexator McVaugh (Myrtaceae), from northern South America, are eaten in certain locales, either fresh or processed into jellies and drinks. Activity-guided fractionation of M. vexator resulted in identification of ellagic acid (1), cyanidin-3-O-glucoside (2), delphinidin-3-O-glucoside (3), 2-O-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid (4), and jaboticabin (5), and latter two compounds are being reported for the first time in this species. Ellagic acid was further examined, and found to inhibit cigarette smoke extract induced MMP-1 expression in vitro, and may be of significance in the treatment of chronic obstructive pulmonary (COPD). Other compounds identified for the first time from M. vexator include cyanidin-3-O-galactoside (6), cyanidin-3-O-arabinoside (7), cyanidin-3-O-rutionoside (8), petunidin (9), peonidin-3-O-galactoside (10) malvidin (11), hyperoside (12), querecetin-3-O-glucoside (13), and guajaverin (14), methyl protocatechuate (15), and protocatechuic acid (16).
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Format: | artículo biblioteca |
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Pergamon Press
2012
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Subjects: | Anthocyanins, MMP-1 inhibition, Depsides, Ellagic acid, COPD, Myrciaria vexator, |
Online Access: | http://hdl.handle.net/10261/100707 |
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dig-ictan-es-10261-1007072021-11-22T13:07:32Z Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy Dastmalchi, K. Flores, Gema Wu, S. H. Ma, C. Dabo, A. J. Whalen, K. Reynertson, K. A. Foronjy, R. F. D'Armiento, J. M. Kennelly, E. J. Anthocyanins MMP-1 inhibition Depsides Ellagic acid COPD Myrciaria vexator The edible fruits of Myrciaria vexator McVaugh (Myrtaceae), from northern South America, are eaten in certain locales, either fresh or processed into jellies and drinks. Activity-guided fractionation of M. vexator resulted in identification of ellagic acid (1), cyanidin-3-O-glucoside (2), delphinidin-3-O-glucoside (3), 2-O-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid (4), and jaboticabin (5), and latter two compounds are being reported for the first time in this species. Ellagic acid was further examined, and found to inhibit cigarette smoke extract induced MMP-1 expression in vitro, and may be of significance in the treatment of chronic obstructive pulmonary (COPD). Other compounds identified for the first time from M. vexator include cyanidin-3-O-galactoside (6), cyanidin-3-O-arabinoside (7), cyanidin-3-O-rutionoside (8), petunidin (9), peonidin-3-O-galactoside (10) malvidin (11), hyperoside (12), querecetin-3-O-glucoside (13), and guajaverin (14), methyl protocatechuate (15), and protocatechuic acid (16). Peer Reviewed 2014-08-06T09:04:04Z 2014-08-06T09:04:04Z 2012 2014-08-06T09:04:04Z artículo http://purl.org/coar/resource_type/c_6501 issn: 1464-3391 Bioorganic and Medicinal Chemistry 20 (2012) http://hdl.handle.net/10261/100707 10.1016/j.bmc.2012.05.013 22739086 https://doi.org/10.1016/j.bmc.2012.05.013 none Pergamon Press |
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Anthocyanins MMP-1 inhibition Depsides Ellagic acid COPD Myrciaria vexator Anthocyanins MMP-1 inhibition Depsides Ellagic acid COPD Myrciaria vexator |
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Anthocyanins MMP-1 inhibition Depsides Ellagic acid COPD Myrciaria vexator Anthocyanins MMP-1 inhibition Depsides Ellagic acid COPD Myrciaria vexator Dastmalchi, K. Flores, Gema Wu, S. H. Ma, C. Dabo, A. J. Whalen, K. Reynertson, K. A. Foronjy, R. F. D'Armiento, J. M. Kennelly, E. J. Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy |
description |
The edible fruits of Myrciaria vexator McVaugh (Myrtaceae), from northern South America, are eaten in certain locales, either fresh or processed into jellies and drinks. Activity-guided fractionation of M. vexator resulted in identification of ellagic acid (1), cyanidin-3-O-glucoside (2), delphinidin-3-O-glucoside (3), 2-O-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxyphenylacetic acid (4), and jaboticabin (5), and latter two compounds are being reported for the first time in this species. Ellagic acid was further examined, and found to inhibit cigarette smoke extract induced MMP-1 expression in vitro, and may be of significance in the treatment of chronic obstructive pulmonary (COPD). Other compounds identified for the first time from M. vexator include cyanidin-3-O-galactoside (6), cyanidin-3-O-arabinoside (7), cyanidin-3-O-rutionoside (8), petunidin (9), peonidin-3-O-galactoside (10) malvidin (11), hyperoside (12), querecetin-3-O-glucoside (13), and guajaverin (14), methyl protocatechuate (15), and protocatechuic acid (16). |
format |
artículo |
topic_facet |
Anthocyanins MMP-1 inhibition Depsides Ellagic acid COPD Myrciaria vexator |
author |
Dastmalchi, K. Flores, Gema Wu, S. H. Ma, C. Dabo, A. J. Whalen, K. Reynertson, K. A. Foronjy, R. F. D'Armiento, J. M. Kennelly, E. J. |
author_facet |
Dastmalchi, K. Flores, Gema Wu, S. H. Ma, C. Dabo, A. J. Whalen, K. Reynertson, K. A. Foronjy, R. F. D'Armiento, J. M. Kennelly, E. J. |
author_sort |
Dastmalchi, K. |
title |
Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy |
title_short |
Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy |
title_full |
Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy |
title_fullStr |
Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy |
title_full_unstemmed |
Edible Myrciria vexator fruits: Bioactive phenolics for potential COPD therapy |
title_sort |
edible myrciria vexator fruits: bioactive phenolics for potential copd therapy |
publisher |
Pergamon Press |
publishDate |
2012 |
url |
http://hdl.handle.net/10261/100707 |
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