Functional Heterologous Gap Junctions in Fundulus Ovarian Follicles Maintain Meiotic Arrest and Permit Hydration during Oocyte Maturation
8 pages, 4 figures, 1 table
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Elsevier
1993-11
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| Online Access: | http://hdl.handle.net/10261/342504 |
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dig-icm-es-10261-3425042024-01-16T12:42:52Z Functional Heterologous Gap Junctions in Fundulus Ovarian Follicles Maintain Meiotic Arrest and Permit Hydration during Oocyte Maturation Cerdà, Joan Petrino, Teresa R. Wallace, Robin A. 8 pages, 4 figures, 1 table The physiological significance of heterologous gap junctions between granulosa cells and the oocyte was investigated in late vitellogenic ovarian follicles of the teleost Fundulus heteroclitus. Lucifer Yellow injected into the oocyte readily passed to the overlying granulosa cells, demonstrating effective dye-coupling. Passage of the fluorescent dye, and hence intercellular communication, was inhibited both by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA) and by 1-octanol, known uncouplers of gap junctions in a variety of invertebrate and vertebrate cell types. Octanol alone also initiated resumption of meiosis in follicle-enclosed oocytes, indicating that granulosa cells normally maintain meiotic arrest, as apparently occurs in mammalian and amphibian follicles. Both PMA and octanol also consistently inhibited the hydration process that normally accompanies meiotic maturation. These results support a previously suggested hypothesis that K+, which is the primary osmotic effector for oocyte hydration, is translocated via gap junctions from granulosa cells to the maturing oocyte Peer reviewed 2024-01-16T12:41:54Z 2024-01-16T12:41:54Z 1993-11 artículo Developmental Biology 160(1): 228-235 (1993) 0012-1606 http://hdl.handle.net/10261/342504 10.1006/dbio.1993.1300 en https://doi.org/10.1006/dbio.1993.1300 Sí none Elsevier |
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biblioteca |
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Europa del Sur |
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Biblioteca del ICM España |
| language |
English |
| description |
8 pages, 4 figures, 1 table |
| format |
artículo |
| author |
Cerdà, Joan Petrino, Teresa R. Wallace, Robin A. |
| spellingShingle |
Cerdà, Joan Petrino, Teresa R. Wallace, Robin A. Functional Heterologous Gap Junctions in Fundulus Ovarian Follicles Maintain Meiotic Arrest and Permit Hydration during Oocyte Maturation |
| author_facet |
Cerdà, Joan Petrino, Teresa R. Wallace, Robin A. |
| author_sort |
Cerdà, Joan |
| title |
Functional Heterologous Gap Junctions in Fundulus Ovarian Follicles Maintain Meiotic Arrest and Permit Hydration during Oocyte Maturation |
| title_short |
Functional Heterologous Gap Junctions in Fundulus Ovarian Follicles Maintain Meiotic Arrest and Permit Hydration during Oocyte Maturation |
| title_full |
Functional Heterologous Gap Junctions in Fundulus Ovarian Follicles Maintain Meiotic Arrest and Permit Hydration during Oocyte Maturation |
| title_fullStr |
Functional Heterologous Gap Junctions in Fundulus Ovarian Follicles Maintain Meiotic Arrest and Permit Hydration during Oocyte Maturation |
| title_full_unstemmed |
Functional Heterologous Gap Junctions in Fundulus Ovarian Follicles Maintain Meiotic Arrest and Permit Hydration during Oocyte Maturation |
| title_sort |
functional heterologous gap junctions in fundulus ovarian follicles maintain meiotic arrest and permit hydration during oocyte maturation |
| publisher |
Elsevier |
| publishDate |
1993-11 |
| url |
http://hdl.handle.net/10261/342504 |
| work_keys_str_mv |
AT cerdajoan functionalheterologousgapjunctionsinfundulusovarianfolliclesmaintainmeioticarrestandpermithydrationduringoocytematuration AT petrinoteresar functionalheterologousgapjunctionsinfundulusovarianfolliclesmaintainmeioticarrestandpermithydrationduringoocytematuration AT wallacerobina functionalheterologousgapjunctionsinfundulusovarianfolliclesmaintainmeioticarrestandpermithydrationduringoocytematuration |
| _version_ |
1792484671327567872 |