Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis

Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis

17 pages, 8 figures, 2 tables, supplementary information https://doi.org/10.1039/D3EN00135K

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Main Authors: Rusconi, Tatiana, Riva, Laura, Punta, Carlo, Solé, Montserrat, Corsi, Ilaria
Other Authors: European Commission
Format: artículo biblioteca
Language:English
Published: Royal Society of Chemistry (UK) 2024
Subjects:Conserve and sustainably use the oceans, seas and marine resources for sustainable development,
Online Access:http://hdl.handle.net/10261/340959
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spelling dig-icm-es-10261-3409592023-12-19T13:12:08Z Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis Rusconi, Tatiana Riva, Laura Punta, Carlo Solé, Montserrat Corsi, Ilaria European Commission Agencia Estatal de Investigación (España) Ministerio de Ciencia e Innovación (España) Conserve and sustainably use the oceans, seas and marine resources for sustainable development 17 pages, 8 figures, 2 tables, supplementary information https://doi.org/10.1039/D3EN00135K The growing application of nanocellulose in various industrial sectors with potential release into the natural environment demands a safety assessment and thus ecotoxicity. Herein, we tested two types of cellulose nanofibers, non-oxidized (CNF) and TEMPO-oxidized (TOCNF), by performing acute in vivo studies with the marine bivalve Mytilus galloprovincialis at 1 μg L−1 and 1 mg L−1 as resembling realistic and acute exposure scenarios, respectively. Uptake and sub-lethal biological responses (lysosomal membrane stability, neurotoxicity, oxidative stress and biotransformation) were investigated along with changes in fibers with water salinity. TOCNF resulted in more dispersion than CNF in natural sea water (NSW) probably owing to higher repulsion among fibers driven by their negative surface charges and colloidal organic material. Both CNF and TOCNF were found in mussel tissues (gills and hemolymph) using labelled stocks. The destabilization of lysosomal membranes of hemocytes was observed; similarly, the inhibition of P-gp efflux activities in the gills was stronger for CNF at the highest concentration (1 mg L−1). Cholinergic enzymes (ASCh–ChE activities) were inhibited in hemocytes, gills and digestive glands regardless of CNF oxidation and concentration tested. In contrast, neither oxidative stress nor biotransformation was affected in the digestive glands and gills of the mussels. Overall, the findings showed CNF uptake by marine mussels and the disruption of gill functionality and immune cells by mechanical interaction even in environmentally realistic exposure scenarios. The paucity of data on the hazards posed by CNF for aquatic species demands that safety aspects be considered in future risk assessment scenarios This study was carried out within the following projects: National Biodiversity Future Center – NBFC, received funding from the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.4 – Call for tender No. 3138 of 16 December 2021, rectified by Decree No. 3175 of 18 December 2021 of Italian Ministry of University and Research funded by the European Union – NextGenerationEU; Award Number: Project code CN_00000033, Concession Decree No. 1034 of 17 June 2022 adopted by the Italian Ministry of University and Research, CUP B63C22000650007; the RETURN Extended Partnership and received funding from the European Union Next-GenerationEU (National Recovery and Resilience Plan – NRRP, Mission 4, Component 2, Investment 1.3 – D.D. 1243 2/8/2022, PE0000005). To the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S). PID2021–122592NB-100 (Ministerio de Ciencia e Innovacion, Agencia Estatal de Investigacion and Fondo Europeo de Desarrollo Regional (FEDER) Peer reviewed 2023-12-19T13:06:19Z 2023-12-19T13:06:19Z 2024 artículo Environmental Science: Nano: (2024) 2051-8153 CEX2019-000928-S http://hdl.handle.net/10261/340959 10.1039/D3EN00135K 2051-8161 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MICIN//PID2021-122592NB-100 https://doi.org/10.1039/D3EN00135K Sí embargo_20241231 Royal Society of Chemistry (UK)
institution ICM ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-icm-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del ICM España
language English
topic Conserve and sustainably use the oceans, seas and marine resources for sustainable development
Conserve and sustainably use the oceans, seas and marine resources for sustainable development
spellingShingle Conserve and sustainably use the oceans, seas and marine resources for sustainable development
Conserve and sustainably use the oceans, seas and marine resources for sustainable development
Rusconi, Tatiana
Riva, Laura
Punta, Carlo
Solé, Montserrat
Corsi, Ilaria
Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis
description 17 pages, 8 figures, 2 tables, supplementary information https://doi.org/10.1039/D3EN00135K
author2 European Commission
author_facet European Commission
Rusconi, Tatiana
Riva, Laura
Punta, Carlo
Solé, Montserrat
Corsi, Ilaria
format artículo
topic_facet Conserve and sustainably use the oceans, seas and marine resources for sustainable development
author Rusconi, Tatiana
Riva, Laura
Punta, Carlo
Solé, Montserrat
Corsi, Ilaria
author_sort Rusconi, Tatiana
title Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis
title_short Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis
title_full Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis
title_fullStr Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis
title_full_unstemmed Environmental safety of nanocellulose: an acute in vivo study with marine mussels Mytilus galloprovincialis
title_sort environmental safety of nanocellulose: an acute in vivo study with marine mussels mytilus galloprovincialis
publisher Royal Society of Chemistry (UK)
publishDate 2024
url http://hdl.handle.net/10261/340959
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