Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?

Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?

14 pages, 3 figures, 1 table

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Bibliographic Details
Main Authors: Piferrer, Francesc, Anastasiadi, Dafni
Other Authors: Ministerio de Ciencia, Innovación y Universidades (España)
Format: artículo biblioteca
Language:English
Published: S. Karger AG 2021-09
Subjects:Sex reversal, Sex steroids, Sex determination, Epigenetics, DNA methylation, Global warming, Climate change, Epigenetic inheritance,
Online Access:http://hdl.handle.net/10261/250331
http://dx.doi.org/10.13039/501100011033
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spelling dig-icm-es-10261-2503312021-10-05T10:55:11Z Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations? Piferrer, Francesc Anastasiadi, Dafni Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Sex reversal Sex steroids Sex determination Epigenetics DNA methylation Global warming Climate change Epigenetic inheritance 14 pages, 3 figures, 1 table Sex determination systems in vertebrates vary along a continuum from genetic (GSD) to environmental sex determination (ESD). Individuals that show a sexual phenotype opposite to their genotypic sex are called sex reversals. Aside from genetic elements, temperature, sex steroids, and exogenous chemicals are common factors triggering sex reversal, a phenomenon that may occur even in strict GSD species. In this paper, we review the literature on instances of sex reversal in fish, amphibians, reptiles, birds, and mammals. We focus on the offspring of sex-reversed parents in the instances that they can be produced, and show that in all cases studied the offspring of these sex-reversed parents exhibit a higher sensitivity to environmental perturbations than the offspring of non-sex-reversed parents. We suggest that the inheritance of this sensitivity, aside from possible genetic factors, is likely to be mediated by epigenetic mechanisms such as DNA methylation, since these mechanisms are responsive to environmental cues, and epigenetic modifications can be transmitted to the subsequent generations. Species with a chromosomal GSD system with environmental sensitivity and availability of genetic sex markers should be employed to further test whether offspring of sex-reversed parents have greater sensitivity to environmental perturbations. Future studies could also benefit from detailed whole-genome data in order to elucidate the underlying molecular mechanisms. Finally, we discuss the consequences of such higher sensitivity in the context of global climate change The study was supported by Spanish Ministry of Science grant PID2019-108888RB-I00 to F.P. With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000928-S) Peer reviewed 2021-09-16T08:47:10Z 2021-09-16T08:47:10Z 2021-09 artículo http://purl.org/coar/resource_type/c_6501 Sexual Development 15(1-3): 134-147 (2021) 1661-5425 CEX2019-000928-S http://hdl.handle.net/10261/250331 10.1159/000515192 1661-5433 http://dx.doi.org/10.13039/501100011033 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108888RB-I00 https://doi.org/10.1159/000515192 Sí none S. Karger AG
institution ICM ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-icm-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del ICM España
language English
topic Sex reversal
Sex steroids
Sex determination
Epigenetics
DNA methylation
Global warming
Climate change
Epigenetic inheritance
Sex reversal
Sex steroids
Sex determination
Epigenetics
DNA methylation
Global warming
Climate change
Epigenetic inheritance
spellingShingle Sex reversal
Sex steroids
Sex determination
Epigenetics
DNA methylation
Global warming
Climate change
Epigenetic inheritance
Sex reversal
Sex steroids
Sex determination
Epigenetics
DNA methylation
Global warming
Climate change
Epigenetic inheritance
Piferrer, Francesc
Anastasiadi, Dafni
Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?
description 14 pages, 3 figures, 1 table
author2 Ministerio de Ciencia, Innovación y Universidades (España)
author_facet Ministerio de Ciencia, Innovación y Universidades (España)
Piferrer, Francesc
Anastasiadi, Dafni
format artículo
topic_facet Sex reversal
Sex steroids
Sex determination
Epigenetics
DNA methylation
Global warming
Climate change
Epigenetic inheritance
author Piferrer, Francesc
Anastasiadi, Dafni
author_sort Piferrer, Francesc
title Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?
title_short Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?
title_full Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?
title_fullStr Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?
title_full_unstemmed Do the Offspring of Sex Reversals Have Higher Sensitivity to Environmental Perturbations?
title_sort do the offspring of sex reversals have higher sensitivity to environmental perturbations?
publisher S. Karger AG
publishDate 2021-09
url http://hdl.handle.net/10261/250331
http://dx.doi.org/10.13039/501100011033
work_keys_str_mv AT piferrerfrancesc dotheoffspringofsexreversalshavehighersensitivitytoenvironmentalperturbations
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