Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads

Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads

8 pages, 6 figures, supplementary data https://doi.org/10.1016/j.fsi.2019.12.013

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Bibliographic Details
Main Authors: Caballero-Huertas, Marta, Moraleda, J., Joly, Sílvia, Ribas, Laia
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Published: Academic Press 2020-02
Subjects:Immune, Epimarkers, Methylation, Gene expression, Gonads,
Online Access:http://hdl.handle.net/10261/199903
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100011033
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spelling dig-icm-es-10261-1999032021-09-16T05:57:16Z Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads Caballero-Huertas, Marta Moraleda, J. Joly, Sílvia Ribas, Laia Ministerio de Economía y Competitividad (España) Agencia Estatal de Investigación (España) Immune Epimarkers Methylation Gene expression Gonads 8 pages, 6 figures, supplementary data https://doi.org/10.1016/j.fsi.2019.12.013 There is crosstalk between the immune and reproductive systems in which sexual dimorphism is a common pattern in vertebrates. In recent years, epigenetics has emerged as a way to study the molecular mechanisms involved in gonadal development, those responsible for integrating environmental information that contribute to assigning a specific sexual phenotype (either an ovary or a testis). The knowledge of epigenetic mechanisms in certain molecular processes allows the development of epigenetic markers. In fish gonads, the existence of reproduction-immune system interactions is known, although the epigenetic mechanisms involved are far from clear. Here, we used the zebrafish (Danio rerio) as a model to study the DNA methylation patterns in gonads of two well-known innate immune genes: IL1β and Casp9. DNA methylation levels were studied by a candidate gene approach at single nucleotide resolution and gene expression analyses were also carried out. Results showed that there was clear sexual dimorphism in the DNA methylation levels of the two immune genes studied, being significantly higher in the testes when compared to the ovaries. In summary, and although further research is needed, this paper presents sexual dimorphic methylation patterns of two immune-related genes, thus sex-biased differences in methylation profiles should considered when analyzing immune responses in fish. Data showed here can help to develop epimarkers with forthcoming applications in livestock and fish farming production, for example, in immune fish diseases or sexual control programs as epigenetic molecular tools to predict environmental pressure in the gonads This study was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) grant AGL2015-73864-JIN “Ambisex” to LR. LR and JM were supported by “Ambisex” contracts With the funding support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S), of the Spanish Research Agency (AEI) 2020-02-06T13:41:29Z 2020-02-06T13:41:29Z 2020-02 2020-02-06T13:41:29Z artículo http://purl.org/coar/resource_type/c_6501 issn: 1050-4648 e-issn: 1095-9947 Fish and Shellfish Immunology 97: 648-655 (2020) CEX2019-000928-S http://hdl.handle.net/10261/199903 10.1016/j.fsi.2019.12.013 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-73864-JIN https://doi.org/10.1016/j.fsi.2019.12.013 Sí open Academic Press
institution ICM ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-icm-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del ICM España
topic Immune
Epimarkers
Methylation
Gene expression
Gonads
Immune
Epimarkers
Methylation
Gene expression
Gonads
spellingShingle Immune
Epimarkers
Methylation
Gene expression
Gonads
Immune
Epimarkers
Methylation
Gene expression
Gonads
Caballero-Huertas, Marta
Moraleda, J.
Joly, Sílvia
Ribas, Laia
Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads
description 8 pages, 6 figures, supplementary data https://doi.org/10.1016/j.fsi.2019.12.013
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Caballero-Huertas, Marta
Moraleda, J.
Joly, Sílvia
Ribas, Laia
format artículo
topic_facet Immune
Epimarkers
Methylation
Gene expression
Gonads
author Caballero-Huertas, Marta
Moraleda, J.
Joly, Sílvia
Ribas, Laia
author_sort Caballero-Huertas, Marta
title Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads
title_short Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads
title_full Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads
title_fullStr Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads
title_full_unstemmed Immune genes, IL1β and Casp9, show sexual dimorphic methylation patterns in zebrafish gonads
title_sort immune genes, il1β and casp9, show sexual dimorphic methylation patterns in zebrafish gonads
publisher Academic Press
publishDate 2020-02
url http://hdl.handle.net/10261/199903
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100011033
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AT moraledaj immunegenesil1bandcasp9showsexualdimorphicmethylationpatternsinzebrafishgonads
AT jolysilvia immunegenesil1bandcasp9showsexualdimorphicmethylationpatternsinzebrafishgonads
AT ribaslaia immunegenesil1bandcasp9showsexualdimorphicmethylationpatternsinzebrafishgonads
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