Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass

Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass

13 pages, 4 figures, supplementary data https://doi.org/10.1093/molbev/msz153

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Bibliographic Details
Main Authors: Anastasiadi, Dafni, Piferrer, Francesc
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Published: Society for Molecular Biology and Evolution 2019-10
Subjects:Epimutation, Neural crest, Transgenerational effects, Glutamate receptors, Domestication syndrome, Developmental processes, Animal domestication, Epigenetics,
Online Access:http://hdl.handle.net/10261/192464
http://dx.doi.org/10.13039/501100003329
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spelling dig-icm-es-10261-1924642021-12-28T16:12:27Z Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass Anastasiadi, Dafni Piferrer, Francesc Ministerio de Economía y Competitividad (España) Epimutation Neural crest Transgenerational effects Glutamate receptors Domestication syndrome Developmental processes Animal domestication Epigenetics 13 pages, 4 figures, supplementary data https://doi.org/10.1093/molbev/msz153 Domestication of wild animals induces a set of phenotypic characteristics collectively known as the domestication syndrome. However, how this syndrome emerges is still not clear. Recently, the neural crest cell deficit hypothesis proposed that it is generated by a mildly disrupted neural crest cell developmental program, but clear support is lacking due to the difficulties of distinguishing pure domestication effects from preexisting genetic differences between farmed and wild mammals and birds. Here, we use a farmed fish as model to investigate the role of persistent changes in DNA methylation (epimutations) in the process of domestication. We show that early domesticates of sea bass, with no genetic differences with wild counterparts, contain epimutations in tissues with different embryonic origins. About one fifth of epimutations that persist into adulthood are established by the time of gastrulation and affect genes involved in developmental processes that are expressed in embryonic structures, including the neural crest. Some of these genes are differentially expressed in sea bass with lower jaw malformations, a key feature of domestication syndrome. Interestingly, these epimutations significantly overlap with cytosine-to-thymine polymorphisms after 25 years of selective breeding. Furthermore, epimutated genes coincide with genes under positive selection in other domesticates. We argue that the initial stages of domestication include dynamic alterations in DNA methylation of developmental genes that affect the neural crest. Our results indicate a role for epimutations during the beginning of domestication that could be fixed as genetic variants and suggest a conserved molecular process to explain Darwin’s domestication syndrome across vertebrates Research supported by the Spanish Ministry of Economy and Competitiveness (MINECO) grants “Epifarm” (ref. AGL2013-41047-R) and “Epimark” (ref. AGL2016-78710-R) to F.P. D.A. was supported by a PhD scholarship from the Spanish Government (BES-2011-044860) and an Epimark contract Peer Reviewed 2019-10-11T07:19:43Z 2019-10-11T07:19:43Z 2019-10 2019-10-11T07:19:43Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1093/molbev/msz153 issn: 0737-4038 e-issn: 1537-1719 Molecular Biology and Evolution 36(10): 2252–2264 (2019) http://hdl.handle.net/10261/192464 10.1093/molbev/msz153 http://dx.doi.org/10.13039/501100003329 31289822 #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-41047-R info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-78710-R Publisher's version https://doi.org/10.1093/molbev/msz153 Sí open Society for Molecular Biology and Evolution
institution ICM ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-icm-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del ICM España
topic Epimutation
Neural crest
Transgenerational effects
Glutamate receptors
Domestication syndrome
Developmental processes
Animal domestication
Epigenetics
Epimutation
Neural crest
Transgenerational effects
Glutamate receptors
Domestication syndrome
Developmental processes
Animal domestication
Epigenetics
spellingShingle Epimutation
Neural crest
Transgenerational effects
Glutamate receptors
Domestication syndrome
Developmental processes
Animal domestication
Epigenetics
Epimutation
Neural crest
Transgenerational effects
Glutamate receptors
Domestication syndrome
Developmental processes
Animal domestication
Epigenetics
Anastasiadi, Dafni
Piferrer, Francesc
Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass
description 13 pages, 4 figures, supplementary data https://doi.org/10.1093/molbev/msz153
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Anastasiadi, Dafni
Piferrer, Francesc
format artículo
topic_facet Epimutation
Neural crest
Transgenerational effects
Glutamate receptors
Domestication syndrome
Developmental processes
Animal domestication
Epigenetics
author Anastasiadi, Dafni
Piferrer, Francesc
author_sort Anastasiadi, Dafni
title Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass
title_short Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass
title_full Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass
title_fullStr Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass
title_full_unstemmed Epimutations in Developmental Genes Underlie the Onset of Domestication in Farmed European Sea Bass
title_sort epimutations in developmental genes underlie the onset of domestication in farmed european sea bass
publisher Society for Molecular Biology and Evolution
publishDate 2019-10
url http://hdl.handle.net/10261/192464
http://dx.doi.org/10.13039/501100003329
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AT piferrerfrancesc epimutationsindevelopmentalgenesunderlietheonsetofdomesticationinfarmedeuropeanseabass
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