Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bass Dicentrarchus labrax
30 pages, 7 figures, supplementary data https://doi.org/10.1016/j.heliyon.2019.e01201
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Elsevier
2019-02
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| Subjects: | Molecular biology, Physiology, Zoology, Developmental biology, |
| Online Access: | http://hdl.handle.net/10261/177462 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003359 |
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dig-icm-es-10261-1774622021-12-28T16:36:03Z Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bass Dicentrarchus labrax Medina, Paula Gómez, Ana Zanuy, Silvia Blázquez, Mercedes Ministerio de Ciencia e Innovación (España) Generalitat Valenciana Universidad de Antofagasta Molecular biology Physiology Zoology Developmental biology 30 pages, 7 figures, supplementary data https://doi.org/10.1016/j.heliyon.2019.e01201 Retinoic Acid (RA) is a vitamin A derivative present in many biological processes including embryogenesis, organ development and cell differentiation. The RA signaling pathway is essential for the onset of meiosis in tetrapods, although its role in fish reproduction needs further evidence. This study reports the expression profiles of several genes involved in this pathway during sex differentiation and the first reproductive season in European sea bass (Dicentrarchus labrax) gonads. The assessed genes are representative of several steps of the pathway including retinol transport, RA synthesis, nuclear receptors, RA transport and degradation. The study includes a synteny analysis of stra8, a tetrapod meiosis gatekeeper, in several taxa. The results show that, these genes were overexpressed during early gonad development and their expression decreased during meiosis progression in males and during vitellogenesis in females. Specifically, a decrease of cyp26a1, involved in RA degradation, together with an increase of aldh1a2 and aldh1a3, in charge of RA-synthesis, might ensure the availability of high RA levels at the time of meiosis in males and females. Moreover, the absence of stra8 in the European sea bass genome, as well as the conserved genomic neighbourhood found in other taxa, suggest a stra8 independent signaling for RA during meiosis. Taken together, our results might help to better understand the role of RA signaling in teleost gonad development This work was supported by MICINN projects (AGL2011-28890) to Ana Gómez and (AGL2015-67477-C2-2-R) to Mercedes Blázquez, and from the Generalitat Valenciana (Prometeo II/2014/051) to Silvia Zanuy. Paula Medina was supported by a grant from the University of Antofagasta MECE2 (ANT0806) Peer Reviewed 2019-03-07T11:32:16Z 2019-03-07T11:32:16Z 2019-02 2019-03-07T11:32:16Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.heliyon.2019.e01201 e-issn: 2405-8440 Heliyon 5(2): e01201 (2019) http://hdl.handle.net/10261/177462 10.1016/j.heliyon.2019.e01201 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003359 30839897 Publisher's version https://doi.org/10.1016/j.heliyon.2019.e01201 Sí open Elsevier |
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Molecular biology Physiology Zoology Developmental biology Molecular biology Physiology Zoology Developmental biology |
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Molecular biology Physiology Zoology Developmental biology Molecular biology Physiology Zoology Developmental biology Medina, Paula Gómez, Ana Zanuy, Silvia Blázquez, Mercedes Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bass Dicentrarchus labrax |
| description |
30 pages, 7 figures, supplementary data https://doi.org/10.1016/j.heliyon.2019.e01201 |
| author2 |
Ministerio de Ciencia e Innovación (España) |
| author_facet |
Ministerio de Ciencia e Innovación (España) Medina, Paula Gómez, Ana Zanuy, Silvia Blázquez, Mercedes |
| format |
artículo |
| topic_facet |
Molecular biology Physiology Zoology Developmental biology |
| author |
Medina, Paula Gómez, Ana Zanuy, Silvia Blázquez, Mercedes |
| author_sort |
Medina, Paula |
| title |
Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bass Dicentrarchus labrax |
| title_short |
Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bass Dicentrarchus labrax |
| title_full |
Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bass Dicentrarchus labrax |
| title_fullStr |
Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bass Dicentrarchus labrax |
| title_full_unstemmed |
Involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the European sea bass Dicentrarchus labrax |
| title_sort |
involvement of the retinoic acid signaling pathway in sex differentiation and pubertal development in the european sea bass dicentrarchus labrax |
| publisher |
Elsevier |
| publishDate |
2019-02 |
| url |
http://hdl.handle.net/10261/177462 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003359 |
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