Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish

Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish

15 pages, 6 figures, 1 table.-- Special issue Fish Reproduction

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Bibliographic Details
Main Authors: Guiguen, Yann, Fostier, Alexis, Piferrer, Francesc, Chang, Ching-Fong
Format: artículo biblioteca
Language:English
Published: Elsevier 2010-02
Subjects:Aromatase, cyp19a1a, Sex differentiation, Sex change, Fishes, Gonads, Estrogens,
Online Access:http://hdl.handle.net/10261/16851
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spelling dig-icm-es-10261-168512020-11-19T09:35:14Z Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish Guiguen, Yann Fostier, Alexis Piferrer, Francesc Chang, Ching-Fong Aromatase cyp19a1a Sex differentiation Sex change Fishes Gonads Estrogens 15 pages, 6 figures, 1 table.-- Special issue Fish Reproduction The present review focuses on the roles of estrogens and aromatase (Cyp19a1a), the enzyme needed for their synthesis, in fish gonadal sex differentiation. Based on the recent literature, we extend the already well accepted hypothesis of an implication of estrogens and Cyp19a1a in ovarian differentiation to a broader hypothesis that would place estrogens and Cyp19a1a in a pivotal position to control not only ovarian, but also testicular differentiation, in both gonochoristic and hermaphrodite fish species. This working hypothesis states that cyp19a1a up-regulation is needed not only for triggering but also for maintaining ovarian differentiation and that cyp19a1a down-regulation is the only necessary step for inducing a testicular differentiation pathway. When considering arguments for and against, most of the information available for fish supports this hypothesis since either suppression of cyp19a1a gene expression, inhibition of Cyp19a1a enzymatic activity, or blockage of estrogen receptivity are invariably associated with masculinization. This is also consistent with reports on normal gonadal differentiation, and steroid-modulated masculinization with either androgens, aromatase inhibitors or estrogen receptor antagonists, temperature-induced masculinization and protogynous sex change in hermaphrodite species. Concerning the regulation of fish cyp19a1a during gonadal differentiation, the transcription factor foxl2 has been characterized as an ovarian specific upstream regulator of a cyp19a1a promoter that would co-activate cyp19a1a expression, along with some additional partners such as nr5a1 (sf1) or cAMP. In contrast, upstream factors potentially down-regulating cyp19a1a during testicular differentiation are still hypothetical, such as the dmrt1 gene, but their definitive characterization as testicular repressors of cyp19a1a would strongly strengthen the hypothesis that early testicular differentiation would need active repression of cyp19a1a expression Peer reviewed 2009-09-11T06:36:07Z 2009-09-11T06:36:07Z 2010-02 artículo http://purl.org/coar/resource_type/c_6501 General and Comparative Endocrinology 165(3): 352–366 (2010) 0016-6480 http://hdl.handle.net/10261/16851 10.1016/j.ygcen.2009.03.002 en https://doi.org/10.1016/j.ygcen.2009.03.002 none 918459 bytes application/pdf Elsevier
institution ICM ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-icm-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del ICM España
language English
topic Aromatase
cyp19a1a
Sex differentiation
Sex change
Fishes
Gonads
Estrogens
Aromatase
cyp19a1a
Sex differentiation
Sex change
Fishes
Gonads
Estrogens
spellingShingle Aromatase
cyp19a1a
Sex differentiation
Sex change
Fishes
Gonads
Estrogens
Aromatase
cyp19a1a
Sex differentiation
Sex change
Fishes
Gonads
Estrogens
Guiguen, Yann
Fostier, Alexis
Piferrer, Francesc
Chang, Ching-Fong
Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish
description 15 pages, 6 figures, 1 table.-- Special issue Fish Reproduction
format artículo
topic_facet Aromatase
cyp19a1a
Sex differentiation
Sex change
Fishes
Gonads
Estrogens
author Guiguen, Yann
Fostier, Alexis
Piferrer, Francesc
Chang, Ching-Fong
author_facet Guiguen, Yann
Fostier, Alexis
Piferrer, Francesc
Chang, Ching-Fong
author_sort Guiguen, Yann
title Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish
title_short Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish
title_full Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish
title_fullStr Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish
title_full_unstemmed Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish
title_sort ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish
publisher Elsevier
publishDate 2010-02
url http://hdl.handle.net/10261/16851
work_keys_str_mv AT guiguenyann ovarianaromataseandestrogensapivotalroleforgonadalsexdifferentiationandsexchangeinfish
AT fostieralexis ovarianaromataseandestrogensapivotalroleforgonadalsexdifferentiationandsexchangeinfish
AT piferrerfrancesc ovarianaromataseandestrogensapivotalroleforgonadalsexdifferentiationandsexchangeinfish
AT changchingfong ovarianaromataseandestrogensapivotalroleforgonadalsexdifferentiationandsexchangeinfish
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