Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)

Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)

10 pages, 4 figures, 1 table, supporting information http://g3journal.org/content/4/10/1871/suppl/DC1

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Main Authors: Taboada, Xoana, Hermida, Miguel, Pardo, Belén G., Vera, Manuel, Piferrer, Francesc, Viñas, Ana, Bouza, Carmen, Martínez, Paulino
Format: artículo biblioteca
Published: Genetics Society of America 2014-10-01
Subjects:Determination, Genetics of sex, Evolution of sex, Differentiation, Sex genetic, Turbot, Sex determining, Master gene, Comparative, Mapping,
Online Access:http://hdl.handle.net/10261/108808
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spelling dig-icm-es-10261-1088082021-12-27T15:58:11Z Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus) Taboada, Xoana Hermida, Miguel Pardo, Belén G. Vera, Manuel Piferrer, Francesc Viñas, Ana Bouza, Carmen Martínez, Paulino Determination Genetics of sex Evolution of sex Differentiation Sex genetic Turbot Sex determining Master gene Comparative Mapping 10 pages, 4 figures, 1 table, supporting information http://g3journal.org/content/4/10/1871/suppl/DC1 Fish sex determination (SD) systems are varied, suggesting evolutionary changes including either multiple evolution origins of genetic SD from nongenetic systems (such as environmental SD) and/or turnover events replacing one genetic system by another. When genetic SD is found, cytological differentiation between the two members of the sex chromosome pair is often minor or undetectable. The turbot (Scophthalmus maximus), a valuable commercial flatfish, has a ZZ/ZW system and a major SD region on linkage group 5 (LG5), but there are also other minor genetic and environmental influences. We here report refined mapping of the turbot SD region, supported by comparative mapping with model fish species, to identify the turbot master SD gene. Six genes were located to the SD region, two of them associated with gonad development (sox2 and dnajc19). All showed a high association with sex within families (P = 0), but not at the population level, so they are probably partially sex-linked genes, but not SD gene itself. Analysis of crossovers in LG5 using two families confirmed a ZZ/ZW system in turbot and suggested a revised map position for the master gene. Genetic diversity and differentiation for 25 LG5 genetic markers showed no differences between males and females sampled from a wild population, suggesting a recent origin of the SD region in turbot. We also analyzed associations with markers of the most relevant sex-related linkage groups in brill (S. rhombus), a closely related species to turbot; the data suggest that an ancient XX/XY system in brill changed to a ZZ/ZW mechanism in turbot. © 2014 Taboada et al. This research work was supported by the Consellería de Educación e Ordenación Universitaria and the Dirección Xeral de I+D Xunta de Galicia (project 10MMA200027PR) and by the Spanish Government (Consolider Ingenio Aquagenomics: CSD2007-00002 project) and Spanish Ministerio de Ciencia e Innovación (AGL2009-13273) projects Peer Reviewed 2014-12-17T08:01:29Z 2014-12-17T08:01:29Z 2014-10-01 2014-12-17T08:01:33Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1534/g3.114.012328 issn: 2160-1836 e-issn: 2160-1836 G3 4(10): 1871-1880 (2014) http://hdl.handle.net/10261/108808 10.1534/g3.114.012328 25106948 https://doi.org/10.1534/g3.114.012328 open Genetics Society of America
institution ICM ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-icm-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del ICM España
topic Determination
Genetics of sex
Evolution of sex
Differentiation
Sex genetic
Turbot
Sex determining
Master gene
Comparative
Mapping
Determination
Genetics of sex
Evolution of sex
Differentiation
Sex genetic
Turbot
Sex determining
Master gene
Comparative
Mapping
spellingShingle Determination
Genetics of sex
Evolution of sex
Differentiation
Sex genetic
Turbot
Sex determining
Master gene
Comparative
Mapping
Determination
Genetics of sex
Evolution of sex
Differentiation
Sex genetic
Turbot
Sex determining
Master gene
Comparative
Mapping
Taboada, Xoana
Hermida, Miguel
Pardo, Belén G.
Vera, Manuel
Piferrer, Francesc
Viñas, Ana
Bouza, Carmen
Martínez, Paulino
Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)
description 10 pages, 4 figures, 1 table, supporting information http://g3journal.org/content/4/10/1871/suppl/DC1
format artículo
topic_facet Determination
Genetics of sex
Evolution of sex
Differentiation
Sex genetic
Turbot
Sex determining
Master gene
Comparative
Mapping
author Taboada, Xoana
Hermida, Miguel
Pardo, Belén G.
Vera, Manuel
Piferrer, Francesc
Viñas, Ana
Bouza, Carmen
Martínez, Paulino
author_facet Taboada, Xoana
Hermida, Miguel
Pardo, Belén G.
Vera, Manuel
Piferrer, Francesc
Viñas, Ana
Bouza, Carmen
Martínez, Paulino
author_sort Taboada, Xoana
title Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)
title_short Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)
title_full Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)
title_fullStr Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)
title_full_unstemmed Fine Mapping and Evolution of the Major Sex Determining Region in Turbot (Scophthalmus maximus)
title_sort fine mapping and evolution of the major sex determining region in turbot (scophthalmus maximus)
publisher Genetics Society of America
publishDate 2014-10-01
url http://hdl.handle.net/10261/108808
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