Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants
Kinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as Leishmania, that cause disease in humans and animals, and Phytomonas, that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments. In the present work, the antiparasitic activity on Leishmania infantum and Phytomonas davidi of 23 essential oils (EOs) from plants of the Lamiaceae and Asteraceae families, extracted by hydrodistillation (HD) at laboratory scale and steam distillation (SD) in a pilot plant, were evaluated. The chemical compositions of the EOs were determined by gas chromatography-mass spectrometry. Additionally, the cytotoxic activity on mammalian cells of the major components from the most active EOs was evaluated, and their anti-Phytomonas and anti-Leishmania effects analyzed. L. infantum was more sensitive to the EOs than P. davidi. The EOs with the best anti-kinetoplastid activity were S. montana, T. vulgaris, M. suaveolens, and L. luisieri. Steam distillation increased the linalyl acetate, β-caryophyllene, and trans-α-necrodyl acetate contents of the EOs, and decreased the amount of borneol and 1,8 cineol. The major active components of the EOs were tested, with thymol being the strongest anti-Phytomonas compound followed by carvacrol. Our study identified potential treatments against kinetoplastids.
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Multidisciplinary Digital Publishing Institute
2023-02-01
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Subjects: | Natural products, Phytomonas, Leishmania, Cytotoxicity, Lamiaceae, Asteraceae, Thymol, Carvacrol, |
Online Access: | http://hdl.handle.net/10261/346703 |
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dig-ica-es-10261-3467032024-02-12T10:03:46Z Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants Bailén, María Illescas, Cristina Quijada, Mónica Martínez-Díaz, Rafael A. Ochoa, Eneko Gómez-Muñoz, María Teresa Navarro-Rocha, Juliana González-Coloma, Azucena Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Banco Santander Universidad Complutense de Madrid González-Coloma, Azucena [0000-0001-5124-664X] Natural products Phytomonas Leishmania Cytotoxicity Lamiaceae Asteraceae Thymol Carvacrol Kinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as Leishmania, that cause disease in humans and animals, and Phytomonas, that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments. In the present work, the antiparasitic activity on Leishmania infantum and Phytomonas davidi of 23 essential oils (EOs) from plants of the Lamiaceae and Asteraceae families, extracted by hydrodistillation (HD) at laboratory scale and steam distillation (SD) in a pilot plant, were evaluated. The chemical compositions of the EOs were determined by gas chromatography-mass spectrometry. Additionally, the cytotoxic activity on mammalian cells of the major components from the most active EOs was evaluated, and their anti-Phytomonas and anti-Leishmania effects analyzed. L. infantum was more sensitive to the EOs than P. davidi. The EOs with the best anti-kinetoplastid activity were S. montana, T. vulgaris, M. suaveolens, and L. luisieri. Steam distillation increased the linalyl acetate, β-caryophyllene, and trans-α-necrodyl acetate contents of the EOs, and decreased the amount of borneol and 1,8 cineol. The major active components of the EOs were tested, with thymol being the strongest anti-Phytomonas compound followed by carvacrol. Our study identified potential treatments against kinetoplastids. This work has been partially financed by Grants PR108/20-08 (Santander-UCM), PID2020-114207RB-I00 and PID2019-106222RB-C31/SRA (Spanish Ministry of Science and Innovation). Peer reviewed 2024-02-12T10:03:46Z 2024-02-12T10:03:46Z 2023-02-01 artículo Molecules 28(3): 1467 (2023) http://hdl.handle.net/10261/346703 10.3390/molecules28031467 1420-3049 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114207RB-I00/ES/RESISTENCIA A FARMACOS EN PROTOZOOS FLAGELADOS DE MUCOSAS Y ALTERNATIVAS TERAPEUTICAS DE ORIGEN NATURAL/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106222RB-C31/ES/NUEVOS BIO-PRODUCTOS: IDENTIFICACION, PRODUCCION Y APLICACION EN PROTECCION VEGETAL/ Publisher's version https://doi.org/10.3390/molecules28031467 Sí open application/pdf Multidisciplinary Digital Publishing Institute |
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Natural products Phytomonas Leishmania Cytotoxicity Lamiaceae Asteraceae Thymol Carvacrol Natural products Phytomonas Leishmania Cytotoxicity Lamiaceae Asteraceae Thymol Carvacrol |
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Natural products Phytomonas Leishmania Cytotoxicity Lamiaceae Asteraceae Thymol Carvacrol Natural products Phytomonas Leishmania Cytotoxicity Lamiaceae Asteraceae Thymol Carvacrol Bailén, María Illescas, Cristina Quijada, Mónica Martínez-Díaz, Rafael A. Ochoa, Eneko Gómez-Muñoz, María Teresa Navarro-Rocha, Juliana González-Coloma, Azucena Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants |
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Kinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as Leishmania, that cause disease in humans and animals, and Phytomonas, that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments. In the present work, the antiparasitic activity on Leishmania infantum and Phytomonas davidi of 23 essential oils (EOs) from plants of the Lamiaceae and Asteraceae families, extracted by hydrodistillation (HD) at laboratory scale and steam distillation (SD) in a pilot plant, were evaluated. The chemical compositions of the EOs were determined by gas chromatography-mass spectrometry. Additionally, the cytotoxic activity on mammalian cells of the major components from the most active EOs was evaluated, and their anti-Phytomonas and anti-Leishmania effects analyzed. L. infantum was more sensitive to the EOs than P. davidi. The EOs with the best anti-kinetoplastid activity were S. montana, T. vulgaris, M. suaveolens, and L. luisieri. Steam distillation increased the linalyl acetate, β-caryophyllene, and trans-α-necrodyl acetate contents of the EOs, and decreased the amount of borneol and 1,8 cineol. The major active components of the EOs were tested, with thymol being the strongest anti-Phytomonas compound followed by carvacrol. Our study identified potential treatments against kinetoplastids. |
author2 |
Ministerio de Ciencia, Innovación y Universidades (España) |
author_facet |
Ministerio de Ciencia, Innovación y Universidades (España) Bailén, María Illescas, Cristina Quijada, Mónica Martínez-Díaz, Rafael A. Ochoa, Eneko Gómez-Muñoz, María Teresa Navarro-Rocha, Juliana González-Coloma, Azucena |
format |
artículo |
topic_facet |
Natural products Phytomonas Leishmania Cytotoxicity Lamiaceae Asteraceae Thymol Carvacrol |
author |
Bailén, María Illescas, Cristina Quijada, Mónica Martínez-Díaz, Rafael A. Ochoa, Eneko Gómez-Muñoz, María Teresa Navarro-Rocha, Juliana González-Coloma, Azucena |
author_sort |
Bailén, María |
title |
Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants |
title_short |
Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants |
title_full |
Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants |
title_fullStr |
Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants |
title_full_unstemmed |
Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants |
title_sort |
anti-trypanosomatidae activity of essential oils and their main components from selected medicinal plants |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023-02-01 |
url |
http://hdl.handle.net/10261/346703 |
work_keys_str_mv |
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