Great ape genetic diversity and population history
Prado-Martinez, Javier et al.
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Nature Publishing Group
2013-07-25
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| Subjects: | Evolution, Evolutionary biology, |
| Online Access: | http://hdl.handle.net/10261/81075 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100004189 http://dx.doi.org/10.13039/100001229 http://dx.doi.org/10.13039/501100000781 |
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dig-ibe-es-10261-810752021-12-27T15:52:39Z Great ape genetic diversity and population history Prado-Martinez, Javier Lorente-Galdós, Belén Santpere, Gabriel Casals, Ferran Laayouni, Hafid Hernandez, Jessica Hernando-Herraez, Irene Pybus, Marc Petit-Marty, Natalia Fernández-Callejo, Marcos Dabad, Marc Carvalho, Tiago Melé, Marta Comas, David Navarro, Arcadi Bertranpetit, Jaume Marqués-Bonet, Tomàs National Institutes of Health (US) Ministerio de Ciencia e Innovación (España) European Commission Generalitat de Catalunya Max Planck Society Danish Council for Independent Research Zoo de Barcelona G. Harold & Leila Y. Mathers Foundation Ayuntamiento de Barcelona European Research Council Evolution Evolutionary biology Prado-Martinez, Javier et al. Most great ape genetic variation remains uncharacterized1,2; however, its study is critical for understanding population history3–6, recombination7, selection8 and susceptibility to disease9,10.Herewe sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88.8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria–Cameroon/western and central/ eastern populations.Wefind extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over timein different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genomediversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations. We thank the following funding agencies: ERC Starting Grant (260372) to T.M.-B.; NIH grants HG002385 to E.E.E., R01_HG005226 to K.R.V., A.E.W., M.F.H., L.S. and J.D.W., GM100233 and NSF HOMINID grant 1032255 to D.R. and He.Li.;MICINN(Spain)BFU2011-28549to T.M.-B.,BFU2010-19443to Ja.Be.,Spanish Government and FEDER for grants BFU2009-13409-C02-02 and BFU2012-38236 to A.N. and J.P.-M., Direccio´ General de Recerca, Generalitat de Catalunya (Grup de Recerca Consolidat 2009 SGR 1101) to Ja.Be., D.C., A.N. and T.M.-B.; ERC Advanced Grant (233297) and Max Planck Society to S. Paabo; Danish Council for Independent Research Natural Sciences to H.S.; Spanish Grant (CGL-2010-20170) and Zoo de Barcelona (Beca PRIC) to A.R.-H.; EUPRIM-Net to BPRC; DP1ES022577-04 NIH grant to S.A.T.; NSF Grant 0755823 to M.K.G.; P.G. is supported by the G. Harold and Leila Y. Mathers Foundation. A.N. and T.M.-B. are ICREA Research Investigators (Institut Catala d’Estudis i RecercaAvancats delaGeneralitat deCatalunya). J.P.-M. is supported by the Zoo de Barcelona and l’Ajuntament de Barcelona. Peer reviewed 2013-08-28T10:20:40Z 2013-08-28T10:20:40Z 2013-07-25 artículo http://purl.org/coar/resource_type/c_6501 Nature 499: 471-475 (2013) 0028-0836 http://hdl.handle.net/10261/81075 10.1038/nature12228 1476-4687 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100004189 http://dx.doi.org/10.13039/100001229 http://dx.doi.org/10.13039/501100000781 23823723 en Publisher's version http://dx.doi.org/10.1038/nature12228 Sí open Nature Publishing Group |
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Evolution Evolutionary biology Evolution Evolutionary biology Prado-Martinez, Javier Lorente-Galdós, Belén Santpere, Gabriel Casals, Ferran Laayouni, Hafid Hernandez, Jessica Hernando-Herraez, Irene Pybus, Marc Petit-Marty, Natalia Fernández-Callejo, Marcos Dabad, Marc Carvalho, Tiago Melé, Marta Comas, David Navarro, Arcadi Bertranpetit, Jaume Marqués-Bonet, Tomàs Great ape genetic diversity and population history |
| description |
Prado-Martinez, Javier et al. |
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National Institutes of Health (US) |
| author_facet |
National Institutes of Health (US) Prado-Martinez, Javier Lorente-Galdós, Belén Santpere, Gabriel Casals, Ferran Laayouni, Hafid Hernandez, Jessica Hernando-Herraez, Irene Pybus, Marc Petit-Marty, Natalia Fernández-Callejo, Marcos Dabad, Marc Carvalho, Tiago Melé, Marta Comas, David Navarro, Arcadi Bertranpetit, Jaume Marqués-Bonet, Tomàs |
| format |
artículo |
| topic_facet |
Evolution Evolutionary biology |
| author |
Prado-Martinez, Javier Lorente-Galdós, Belén Santpere, Gabriel Casals, Ferran Laayouni, Hafid Hernandez, Jessica Hernando-Herraez, Irene Pybus, Marc Petit-Marty, Natalia Fernández-Callejo, Marcos Dabad, Marc Carvalho, Tiago Melé, Marta Comas, David Navarro, Arcadi Bertranpetit, Jaume Marqués-Bonet, Tomàs |
| author_sort |
Prado-Martinez, Javier |
| title |
Great ape genetic diversity and population history |
| title_short |
Great ape genetic diversity and population history |
| title_full |
Great ape genetic diversity and population history |
| title_fullStr |
Great ape genetic diversity and population history |
| title_full_unstemmed |
Great ape genetic diversity and population history |
| title_sort |
great ape genetic diversity and population history |
| publisher |
Nature Publishing Group |
| publishDate |
2013-07-25 |
| url |
http://hdl.handle.net/10261/81075 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100004189 http://dx.doi.org/10.13039/100001229 http://dx.doi.org/10.13039/501100000781 |
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