The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART

The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART

[Background] Telomere maintenance in Drosophila relies on the targeted transposition of three very special non-LTR retrotransposons, HeT-A, TART, and TAHRE (HTT). The sequences of the retrotransposon array build up the telomere chromatin in this organism. We have recently reported the role of the chromosomal protein Putzig/Z4 in maintaining a proper chromatin structure at the telomere domain of Drosophila. Because the Putzig protein has been found in different cellular complexes related with cell proliferation, development, and immunity, we decided to investigate whether the previously described Putzig partners, DREF/TRF2 and KEN, could also be involved in the telomere function in this organism.

Saved in:
Bibliographic Details
Main Authors: Silva-Sousa, Rute, Varela, Míriam D, Casacuberta, Elena
Other Authors: Ministerio de Ciencia e Innovación (España)
Format: artículo biblioteca
Language:English
Published: BioMed Central 2013-07-03
Online Access:http://hdl.handle.net/10261/80292
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100001871
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-ibe-es-10261-80292
record_format koha
spelling dig-ibe-es-10261-802922021-12-28T16:09:54Z The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART Silva-Sousa, Rute Varela, Míriam D Casacuberta, Elena Ministerio de Ciencia e Innovación (España) Consejo Superior de Investigaciones Científicas (España) Fundação para a Ciência e a Tecnologia (Portugal) [Background] Telomere maintenance in Drosophila relies on the targeted transposition of three very special non-LTR retrotransposons, HeT-A, TART, and TAHRE (HTT). The sequences of the retrotransposon array build up the telomere chromatin in this organism. We have recently reported the role of the chromosomal protein Putzig/Z4 in maintaining a proper chromatin structure at the telomere domain of Drosophila. Because the Putzig protein has been found in different cellular complexes related with cell proliferation, development, and immunity, we decided to investigate whether the previously described Putzig partners, DREF/TRF2 and KEN, could also be involved in the telomere function in this organism. [Results] We have found that mutant alleles for Dref/Trf2 and Ken show alterations in HeT-A and TART expression, suggesting a possible role of these protein complexes in the regulation of the telomere retrotransposons. In agreement, both HeT-A and TART contain the specific DNA binding sequences for the DREF and the KEN protein proteins. [Conclusions] We have identified three new negative regulators involved in the control of the expression of the telomeric retrotransposons, Dref, Trf2, and Ken. Our results offer some clues on which other chromatin-related proteins might be involved in telomere regulation and retrotransposon control. This work was supported by a grant from the Spanish Ministry of Science and Innovation BFU2009-08318/BMC to EC, a PhD Fellowship Fundação para a Ciência e Tecnologia, Portugal SFRH / BD / 36291 / 2007 to RS-S, and a JAEintro (JAEINT_11_01262) from the CSIC to MDV. Peer Reviewed 2013-07-29T15:10:31Z 2013-07-29T15:10:31Z 2013-07-03 2013-07-29T15:10:31Z artículo http://purl.org/coar/resource_type/c_6501 Mobile DNA 4(1): 18 (2013) http://hdl.handle.net/10261/80292 10.1186/1759-8753-4-18 1759-8753 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100001871 23822164 en Publisher’s version http://dx.doi.org/10.1186/1759-8753-4-18 Sí open BioMed Central
institution IBE ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ibe-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IBE España
language English
description [Background] Telomere maintenance in Drosophila relies on the targeted transposition of three very special non-LTR retrotransposons, HeT-A, TART, and TAHRE (HTT). The sequences of the retrotransposon array build up the telomere chromatin in this organism. We have recently reported the role of the chromosomal protein Putzig/Z4 in maintaining a proper chromatin structure at the telomere domain of Drosophila. Because the Putzig protein has been found in different cellular complexes related with cell proliferation, development, and immunity, we decided to investigate whether the previously described Putzig partners, DREF/TRF2 and KEN, could also be involved in the telomere function in this organism.
author2 Ministerio de Ciencia e Innovación (España)
author_facet Ministerio de Ciencia e Innovación (España)
Silva-Sousa, Rute
Varela, Míriam D
Casacuberta, Elena
format artículo
author Silva-Sousa, Rute
Varela, Míriam D
Casacuberta, Elena
spellingShingle Silva-Sousa, Rute
Varela, Míriam D
Casacuberta, Elena
The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART
author_sort Silva-Sousa, Rute
title The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART
title_short The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART
title_full The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART
title_fullStr The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART
title_full_unstemmed The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART
title_sort putzig partners dref, trf2 and ken are involved in the regulation of the drosophila telomere retrotransposons, het-a and tart
publisher BioMed Central
publishDate 2013-07-03
url http://hdl.handle.net/10261/80292
http://dx.doi.org/10.13039/501100004837
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/501100001871
work_keys_str_mv AT silvasousarute theputzigpartnersdreftrf2andkenareinvolvedintheregulationofthedrosophilatelomereretrotransposonshetaandtart
AT varelamiriamd theputzigpartnersdreftrf2andkenareinvolvedintheregulationofthedrosophilatelomereretrotransposonshetaandtart
AT casacubertaelena theputzigpartnersdreftrf2andkenareinvolvedintheregulationofthedrosophilatelomereretrotransposonshetaandtart
AT silvasousarute putzigpartnersdreftrf2andkenareinvolvedintheregulationofthedrosophilatelomereretrotransposonshetaandtart
AT varelamiriamd putzigpartnersdreftrf2andkenareinvolvedintheregulationofthedrosophilatelomereretrotransposonshetaandtart
AT casacubertaelena putzigpartnersdreftrf2andkenareinvolvedintheregulationofthedrosophilatelomereretrotransposonshetaandtart
_version_ 1777668560001171456

Similar Items