Distribution of prolactin receptor in frog (Rana Ridibunda) dorsal skin during hibernation
The role of prolactin in the regulation of frog skin functions is still unclear particularly during environmental changes. In this study, prolactin receptor (PRLR) was detected in active and hibernating frog dorsal skin using immunohistochemical method. PRLR immunoreactivity in active frogs was observed in the epidermis, in the secretory epithelium of granular glands and the secretory channel cells of the glands. Myoepithelial cells of granular glands that started accumulating secretory material or those with a full lumen were PRLR immunoreactive, while some myoepithelial cells of empty granular glands were negative for PRLR. In hibernating frogs, this immunoreactivity was observed in the same regions; however, immunoreactivity was more intense than that in active frogs. PCNA was employed for detection of proliferative activity of PRL in the dorsal skin, and immunoreactivity was detected in the nuclei of a few epidermis cells and in the duct of glands of active frogs. The number of immunoreactive nuclei in these regions increased in hibernating and in prolactin injected groups. We conclude that prolactin provides morphological and functional integrity of skin stimulating the proliferation and regulating the function of granular glands and plays an important role in the adaptation of amphibians to the long winter period. © 2011 Akademiai Kiado, Budapest.
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2011
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dig-ibe-es-10261-505082016-02-17T06:41:36Z Distribution of prolactin receptor in frog (Rana Ridibunda) dorsal skin during hibernation Sengezer-Inceli, Meliha Murathanoglu, Osman Castillo, Songül Süren Sancar-Bas, Serap Kaptan, Engin The role of prolactin in the regulation of frog skin functions is still unclear particularly during environmental changes. In this study, prolactin receptor (PRLR) was detected in active and hibernating frog dorsal skin using immunohistochemical method. PRLR immunoreactivity in active frogs was observed in the epidermis, in the secretory epithelium of granular glands and the secretory channel cells of the glands. Myoepithelial cells of granular glands that started accumulating secretory material or those with a full lumen were PRLR immunoreactive, while some myoepithelial cells of empty granular glands were negative for PRLR. In hibernating frogs, this immunoreactivity was observed in the same regions; however, immunoreactivity was more intense than that in active frogs. PCNA was employed for detection of proliferative activity of PRL in the dorsal skin, and immunoreactivity was detected in the nuclei of a few epidermis cells and in the duct of glands of active frogs. The number of immunoreactive nuclei in these regions increased in hibernating and in prolactin injected groups. We conclude that prolactin provides morphological and functional integrity of skin stimulating the proliferation and regulating the function of granular glands and plays an important role in the adaptation of amphibians to the long winter period. © 2011 Akademiai Kiado, Budapest. Peer Reviewed 2012-05-31T10:17:50Z 2012-05-31T10:17:50Z 2011 2012-05-31T10:17:50Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1556/ABiol.62.2011.4.2 issn: 0236-5383 Acta Biologica Hungarica 62: 349-360 (2011) http://hdl.handle.net/10261/50508 10.1556/ABiol.62.2011.4.2 en http://dx.doi.org/10.1556/ABiol.62.2011.4.2 none Akadémiai Kiadó (Budapest) |
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The role of prolactin in the regulation of frog skin functions is still unclear particularly during environmental changes. In this study, prolactin receptor (PRLR) was detected in active and hibernating frog dorsal skin using immunohistochemical method. PRLR immunoreactivity in active frogs was observed in the epidermis, in the secretory epithelium of granular glands and the secretory channel cells of the glands. Myoepithelial cells of granular glands that started accumulating secretory material or those with a full lumen were PRLR immunoreactive, while some myoepithelial cells of empty granular glands were negative for PRLR. In hibernating frogs, this immunoreactivity was observed in the same regions; however, immunoreactivity was more intense than that in active frogs. PCNA was employed for detection of proliferative activity of PRL in the dorsal skin, and immunoreactivity was detected in the nuclei of a few epidermis cells and in the duct of glands of active frogs. The number of immunoreactive nuclei in these regions increased in hibernating and in prolactin injected groups. We conclude that prolactin provides morphological and functional integrity of skin stimulating the proliferation and regulating the function of granular glands and plays an important role in the adaptation of amphibians to the long winter period. © 2011 Akademiai Kiado, Budapest. |
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Sengezer-Inceli, Meliha Murathanoglu, Osman Castillo, Songül Süren Sancar-Bas, Serap Kaptan, Engin |
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Sengezer-Inceli, Meliha Murathanoglu, Osman Castillo, Songül Süren Sancar-Bas, Serap Kaptan, Engin Distribution of prolactin receptor in frog (Rana Ridibunda) dorsal skin during hibernation |
author_facet |
Sengezer-Inceli, Meliha Murathanoglu, Osman Castillo, Songül Süren Sancar-Bas, Serap Kaptan, Engin |
author_sort |
Sengezer-Inceli, Meliha |
title |
Distribution of prolactin receptor in frog (Rana Ridibunda) dorsal skin during hibernation |
title_short |
Distribution of prolactin receptor in frog (Rana Ridibunda) dorsal skin during hibernation |
title_full |
Distribution of prolactin receptor in frog (Rana Ridibunda) dorsal skin during hibernation |
title_fullStr |
Distribution of prolactin receptor in frog (Rana Ridibunda) dorsal skin during hibernation |
title_full_unstemmed |
Distribution of prolactin receptor in frog (Rana Ridibunda) dorsal skin during hibernation |
title_sort |
distribution of prolactin receptor in frog (rana ridibunda) dorsal skin during hibernation |
publisher |
Akadémiai Kiadó (Budapest) |
publishDate |
2011 |
url |
http://hdl.handle.net/10261/50508 |
work_keys_str_mv |
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