Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives
© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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Nature Publishing Group
2024-05-01
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Biological anthropology Genetic variation Biological anthropology Genetic variation Vilà-Valls, Laura Abdeli, Amine Lucas-Sanchez, Marcel Bekada, Asmahan Calafell, Francesc Benhassine, Traki Comas, David Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives |
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© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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Ministerio de Ciencia, Innovación y Universidades (España) |
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Ministerio de Ciencia, Innovación y Universidades (España) Vilà-Valls, Laura Abdeli, Amine Lucas-Sanchez, Marcel Bekada, Asmahan Calafell, Francesc Benhassine, Traki Comas, David |
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Biological anthropology Genetic variation |
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Vilà-Valls, Laura Abdeli, Amine Lucas-Sanchez, Marcel Bekada, Asmahan Calafell, Francesc Benhassine, Traki Comas, David |
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Vilà-Valls, Laura |
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Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives |
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Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives |
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Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives |
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Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives |
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Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives |
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understanding the genomic heterogeneity of north african imazighen: from broad to microgeographical perspectives |
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Nature Publishing Group |
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2024-05-01 |
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http://hdl.handle.net/10261/361073 |
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dig-ibe-es-10261-3610732024-06-20T09:45:35Z Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives Vilà-Valls, Laura Abdeli, Amine Lucas-Sanchez, Marcel Bekada, Asmahan Calafell, Francesc Benhassine, Traki Comas, David Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) Ministerio de Ciencia e Innovación (España) Lucas-Sanchez, Marcel [0000-0001-6741-3959] Calafell, Francesc [0000-0002-1083-9438] Comas, David [0000-0002-5075-0956] Biological anthropology Genetic variation © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The strategic location of North Africa has led to cultural and demographic shifts, shaping its genetic structure. Historical migrations brought different genetic components that are evident in present-day North African genomes, along with autochthonous components. The Imazighen (plural of Amazigh) are believed to be the descendants of autochthonous North Africans and speak various Amazigh languages, which belong to the Afro-Asiatic language family. However, the arrival of different human groups, especially during the Arab conquest, caused cultural and linguistic changes in local populations, increasing their heterogeneity. We aim to characterize the genetic structure of the region, using the largest Amazigh dataset to date and other reference samples. Our findings indicate microgeographical genetic heterogeneity among Amazigh populations, modeled by various admixture waves and different effective population sizes. A first admixture wave is detected group-wide around the twelfth century, whereas a second wave appears in some Amazigh groups around the nineteenth century. These events involved populations with higher genetic ancestry from south of the Sahara compared to the current North Africans. A plausible explanation would be the historical trans-Saharan slave trade, which lasted from the Roman times to the nineteenth century. Furthermore, our investigation shows that assortative mating in North Africa has been rare. This work was funded by MICIU/AEI/https://doi.org/10.13039/501100011033/ ERF A way of making Europe (grant numbers I-COOP0018; PID2019-106485GB-I00 and PID2022-138755NB-I00). Peer reviewed 2024-06-20T09:45:34Z 2024-06-20T09:45:34Z 2024-05-01 artículo Scientific Reports 14: 9979 (2024) http://hdl.handle.net/10261/361073 10.1038/s41598-024-60568-8 2045-2322 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106485GB-I00/ES/DEMOGRAFIA Y EFICIENCIA DE LA SELECCION NATURAL EN POBLACIONES HUMANAS: UN ANALISIS GENOMICO/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138755NB-I00/ES/DESCIFRANDO LA HISTORIA POBLACIONAL DE LOS ROMANI AMERICANOS A TRAVES DEL ANALISIS DE DIVERSIDAD GENOMICA/ Publisher's version Genome-wide array data of Algerian Imazighen and non-Imazighen are available at the European Genome-phenome Archive (EGA), under accession number EGAS00001007235. The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1038/s41598-024-60568-8 https://doi.org/10.1038/s41598-024-60568-8 Sí open application/pdf Nature Publishing Group |