Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder

Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Main Authors: Aranda, Selena, Muntané, Gerard, Vilella, Elisabet
Other Authors: Brain and Behavior Research Foundation
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2024-02-23
Subjects:Biomarkers, Bipolar disorder, Schizophrenia,
Online Access:http://hdl.handle.net/10261/360683
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spelling dig-ibe-es-10261-3606832024-06-18T07:54:56Z Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder Aranda, Selena Muntané, Gerard Vilella, Elisabet Brain and Behavior Research Foundation Instituto de Salud Carlos III Agència de Gestió d'Ajuts Universitaris i de Recerca Muntané, Gerard [0000-0003-1541-8365] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] Biomarkers Bipolar disorder Schizophrenia © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. DDR1 has been linked to schizophrenia (SCZ) and bipolar disorder (BD) in association studies. DDR1 encodes 58 distinct transcripts, which can be translated into five isoforms (DDR1a-e) and are expressed in the brain. However, the transcripts expressed in each brain cell type, their functions and their involvement in SCZ and BD remain unknown. Here, to infer the processes in which DDR1 transcripts are involved, we used transcriptomic data from the human brain dorsolateral prefrontal cortex of healthy controls (N = 936) and performed weighted gene coexpression network analysis followed by enrichment analyses. Then, to explore the involvement of DDR1 transcripts in SCZ (N = 563) and BD (N = 222), we studied the association of coexpression modules with disease and performed differential expression and transcript significance analyses. Some DDR1 transcripts were distributed across five coexpression modules identified in healthy controls (MHC). MHC1 and MHC2 were enriched in the cell cycle and proliferation of astrocytes and OPCs; MHC3 and MHC4 were enriched in oligodendrocyte differentiation and myelination; and MHC5 was enriched in neurons and synaptic transmission. Most of the DDR1 transcripts associated with SCZ and BD pertained to MHC1 and MHC2. Altogether, our results suggest that DDR1 expression might be altered in SCZ and BD via the proliferation of astrocytes and OPCs, suggesting that these processes are relevant in psychiatric disorders. The study was supported by grants from the Brain and Behavior Research Foundation (2017 NARSAD Independent grant, #25811 to EV), Instituto de Salud Carlos III (Research Project PI18/00954 to EV), and Agència de Gestió d’Ajuts Universitaris i de Recerca (2021SGR01065 to EV). Selena Aranda was the recipient of a predoctoral fellowship granted by the Instituto de Salud Carlos III (PFIS FI19/00268). Peer reviewed 2024-06-18T07:54:56Z 2024-06-18T07:54:56Z 2024-02-23 artículo Translational psychiatry 14: 112 (2024) http://hdl.handle.net/10261/360683 10.1038/s41398-024-02823-0 2158-3188 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F00954/ES/VIGILANCIA Y CONTROL EN TIEMPO REAL DE LA INFECCION RELACIONADA CON LA ASISTENCIA SANITARIA (IRAS) POR BACTERIAS MULTIRRESISTENTES A TRAVES DE LA SECUENCIACION DE GENOMAS COMPLETOS./ Publisher's version The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1038/s41398-024-02823-0 https://doi.org/10.1038/s41398-024-02823-0 Sí open application/pdf Multidisciplinary Digital Publishing Institute
institution IBE ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ibe-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IBE España
language English
topic Biomarkers
Bipolar disorder
Schizophrenia
Biomarkers
Bipolar disorder
Schizophrenia
spellingShingle Biomarkers
Bipolar disorder
Schizophrenia
Biomarkers
Bipolar disorder
Schizophrenia
Aranda, Selena
Muntané, Gerard
Vilella, Elisabet
Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
description © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
author2 Brain and Behavior Research Foundation
author_facet Brain and Behavior Research Foundation
Aranda, Selena
Muntané, Gerard
Vilella, Elisabet
format artículo
topic_facet Biomarkers
Bipolar disorder
Schizophrenia
author Aranda, Selena
Muntané, Gerard
Vilella, Elisabet
author_sort Aranda, Selena
title Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
title_short Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
title_full Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
title_fullStr Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
title_full_unstemmed Coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
title_sort coexpression network analysis of the adult brain sheds light on the pathogenic mechanism of ddr1 in schizophrenia and bipolar disorder
publisher Multidisciplinary Digital Publishing Institute
publishDate 2024-02-23
url http://hdl.handle.net/10261/360683
work_keys_str_mv AT arandaselena coexpressionnetworkanalysisoftheadultbrainshedslightonthepathogenicmechanismofddr1inschizophreniaandbipolardisorder
AT muntanegerard coexpressionnetworkanalysisoftheadultbrainshedslightonthepathogenicmechanismofddr1inschizophreniaandbipolardisorder
AT vilellaelisabet coexpressionnetworkanalysisoftheadultbrainshedslightonthepathogenicmechanismofddr1inschizophreniaandbipolardisorder
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