DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes

[Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes.

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Main Authors: García-Ruiz, Beatriz, Castro de Moura, Manuel, Muntané, Gerard, Martorell, Lourdes, Bosch, Elena, Esteller, Manel, Canales-Rodríguez, Erick Jorge, Pomarol-Clotet, Edith, Jiménez, Esther, Vieta, Eduard, Vilella, Elisabet
Other Authors: García- Ruiz, Beatriz [0000-0001-9552-949X]
Format: artículo biblioteca
Language:English
Published: Future Medicine 2021-05-04
Subjects:Bipolar disorder, Discoidin domain receptor 1, Gene expression, Human brain, Methylation, Myelin genes,
Online Access:http://hdl.handle.net/10261/250836
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spelling dig-ibe-es-10261-2508362022-06-23T10:10:43Z DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes García-Ruiz, Beatriz Castro de Moura, Manuel Muntané, Gerard Martorell, Lourdes Bosch, Elena Esteller, Manel Canales-Rodríguez, Erick Jorge Pomarol-Clotet, Edith Jiménez, Esther Vieta, Eduard Vilella, Elisabet García- Ruiz, Beatriz [0000-0001-9552-949X] Castro de Moura, Manuel [0000-0002-8488-5306] Muntané, Gerard [0000-0003-1541-8365] Martorell, Lourdes [0000-0003-4999-2197] Bosch, Elena [0000-0003-2848-103X] Esteller, Manel [0000-0003-4490-6093] Canales-Rodríguez, Erick Jorge [0000-0001-6421-2633] Pomarol-Clotet, Edith [0000-0002-8159-8563] Jiménez, Esther [0000-0001-6929-6207] Vieta, Eduard [0000-0002-0548-0053] Vilella, Elisabet [0000-0002-1887-5919] Bipolar disorder Discoidin domain receptor 1 Gene expression Human brain Methylation Myelin genes [Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. [Materials & methods] Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. [Results] DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. [Conclusion] DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination. Peer reviewed 2021-09-23T11:19:27Z 2021-09-23T11:19:27Z 2021-05-04 artículo http://purl.org/coar/resource_type/c_6501 Epigenomics 13(11): (2021) 1750-1911 http://hdl.handle.net/10261/250836 10.2217/epi-2021-0006 1750-192X en https://doi.org/10.2217/epi-2021-0006 Sí none application/pdf Future Medicine
institution IBE ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ibe-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IBE España
language English
topic Bipolar disorder
Discoidin domain receptor 1
Gene expression
Human brain
Methylation
Myelin genes
Bipolar disorder
Discoidin domain receptor 1
Gene expression
Human brain
Methylation
Myelin genes
spellingShingle Bipolar disorder
Discoidin domain receptor 1
Gene expression
Human brain
Methylation
Myelin genes
Bipolar disorder
Discoidin domain receptor 1
Gene expression
Human brain
Methylation
Myelin genes
García-Ruiz, Beatriz
Castro de Moura, Manuel
Muntané, Gerard
Martorell, Lourdes
Bosch, Elena
Esteller, Manel
Canales-Rodríguez, Erick Jorge
Pomarol-Clotet, Edith
Jiménez, Esther
Vieta, Eduard
Vilella, Elisabet
DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
description [Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes.
author2 García- Ruiz, Beatriz [0000-0001-9552-949X]
author_facet García- Ruiz, Beatriz [0000-0001-9552-949X]
García-Ruiz, Beatriz
Castro de Moura, Manuel
Muntané, Gerard
Martorell, Lourdes
Bosch, Elena
Esteller, Manel
Canales-Rodríguez, Erick Jorge
Pomarol-Clotet, Edith
Jiménez, Esther
Vieta, Eduard
Vilella, Elisabet
format artículo
topic_facet Bipolar disorder
Discoidin domain receptor 1
Gene expression
Human brain
Methylation
Myelin genes
author García-Ruiz, Beatriz
Castro de Moura, Manuel
Muntané, Gerard
Martorell, Lourdes
Bosch, Elena
Esteller, Manel
Canales-Rodríguez, Erick Jorge
Pomarol-Clotet, Edith
Jiménez, Esther
Vieta, Eduard
Vilella, Elisabet
author_sort García-Ruiz, Beatriz
title DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
title_short DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
title_full DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
title_fullStr DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
title_full_unstemmed DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
title_sort ddr1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
publisher Future Medicine
publishDate 2021-05-04
url http://hdl.handle.net/10261/250836
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