DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes
[Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes.
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Future Medicine
2021-05-04
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Subjects: | Bipolar disorder, Discoidin domain receptor 1, Gene expression, Human brain, Methylation, Myelin genes, |
Online Access: | http://hdl.handle.net/10261/250836 |
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dig-ibe-es-10261-2508362022-06-23T10:10:43Z DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes García-Ruiz, Beatriz Castro de Moura, Manuel Muntané, Gerard Martorell, Lourdes Bosch, Elena Esteller, Manel Canales-Rodríguez, Erick Jorge Pomarol-Clotet, Edith Jiménez, Esther Vieta, Eduard Vilella, Elisabet García- Ruiz, Beatriz [0000-0001-9552-949X] Castro de Moura, Manuel [0000-0002-8488-5306] Muntané, Gerard [0000-0003-1541-8365] Martorell, Lourdes [0000-0003-4999-2197] Bosch, Elena [0000-0003-2848-103X] Esteller, Manel [0000-0003-4490-6093] Canales-Rodríguez, Erick Jorge [0000-0001-6421-2633] Pomarol-Clotet, Edith [0000-0002-8159-8563] Jiménez, Esther [0000-0001-6929-6207] Vieta, Eduard [0000-0002-0548-0053] Vilella, Elisabet [0000-0002-1887-5919] Bipolar disorder Discoidin domain receptor 1 Gene expression Human brain Methylation Myelin genes [Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. [Materials & methods] Genome-wide profiling of DNA methylation (Infinium MethylationEPIC BeadChip) corrected for glial composition and DDR1 gene expression analysis in the occipital cortices of individuals with BD (n = 15) and healthy controls (n = 15) were conducted. [Results] DDR1 5-methylcytosine levels were increased and directly associated with DDR1b mRNA expression in the brains of BD patients. We also observed that DDR1 was comethylated with a group of myelin genes. [Conclusion] DDR1 is hypermethylated in BD brain tissue and is associated with isoform expression. Additionally, DDR1 comethylation with myelin genes supports the role of this receptor in myelination. Peer reviewed 2021-09-23T11:19:27Z 2021-09-23T11:19:27Z 2021-05-04 artículo http://purl.org/coar/resource_type/c_6501 Epigenomics 13(11): (2021) 1750-1911 http://hdl.handle.net/10261/250836 10.2217/epi-2021-0006 1750-192X en https://doi.org/10.2217/epi-2021-0006 Sí none application/pdf Future Medicine |
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Bipolar disorder Discoidin domain receptor 1 Gene expression Human brain Methylation Myelin genes Bipolar disorder Discoidin domain receptor 1 Gene expression Human brain Methylation Myelin genes |
spellingShingle |
Bipolar disorder Discoidin domain receptor 1 Gene expression Human brain Methylation Myelin genes Bipolar disorder Discoidin domain receptor 1 Gene expression Human brain Methylation Myelin genes García-Ruiz, Beatriz Castro de Moura, Manuel Muntané, Gerard Martorell, Lourdes Bosch, Elena Esteller, Manel Canales-Rodríguez, Erick Jorge Pomarol-Clotet, Edith Jiménez, Esther Vieta, Eduard Vilella, Elisabet DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes |
description |
[Aim] To investigate DDR1 methylation in the brains of bipolar disorder (BD) patients and its association with DDR1 mRNA levels and comethylation with myelin genes. |
author2 |
García- Ruiz, Beatriz [0000-0001-9552-949X] |
author_facet |
García- Ruiz, Beatriz [0000-0001-9552-949X] García-Ruiz, Beatriz Castro de Moura, Manuel Muntané, Gerard Martorell, Lourdes Bosch, Elena Esteller, Manel Canales-Rodríguez, Erick Jorge Pomarol-Clotet, Edith Jiménez, Esther Vieta, Eduard Vilella, Elisabet |
format |
artículo |
topic_facet |
Bipolar disorder Discoidin domain receptor 1 Gene expression Human brain Methylation Myelin genes |
author |
García-Ruiz, Beatriz Castro de Moura, Manuel Muntané, Gerard Martorell, Lourdes Bosch, Elena Esteller, Manel Canales-Rodríguez, Erick Jorge Pomarol-Clotet, Edith Jiménez, Esther Vieta, Eduard Vilella, Elisabet |
author_sort |
García-Ruiz, Beatriz |
title |
DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes |
title_short |
DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes |
title_full |
DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes |
title_fullStr |
DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes |
title_full_unstemmed |
DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes |
title_sort |
ddr1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes |
publisher |
Future Medicine |
publishDate |
2021-05-04 |
url |
http://hdl.handle.net/10261/250836 |
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