Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6
This article belongs to the Special Issue Scavenger Receptors in Inflammation.
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| Language: | English |
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Multidisciplinary Digital Publishing Institute
2021-05-18
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| Subjects: | Scavenger receptors, CD5, CD6, Immune response, Cancer, Autoimmunity, Infections, Natural selection, Human genetics, Single nucleotide polymorphisms, |
| Online Access: | http://hdl.handle.net/10261/247770 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100003030 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003176 |
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Scavenger receptors CD5 CD6 Immune response Cancer Autoimmunity Infections Natural selection Human genetics Single nucleotide polymorphisms Scavenger receptors CD5 CD6 Immune response Cancer Autoimmunity Infections Natural selection Human genetics Single nucleotide polymorphisms |
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Scavenger receptors CD5 CD6 Immune response Cancer Autoimmunity Infections Natural selection Human genetics Single nucleotide polymorphisms Scavenger receptors CD5 CD6 Immune response Cancer Autoimmunity Infections Natural selection Human genetics Single nucleotide polymorphisms Casadó-Llombart, Sergi Velasco-de Andrés, María Catalá, Cristina Leyton-Pereira, Alejandra Lozano, Francisco Bosch, Elena Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6 |
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This article belongs to the Special Issue Scavenger Receptors in Inflammation. |
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Ministerio de Economía y Competitividad (España) |
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Ministerio de Economía y Competitividad (España) Casadó-Llombart, Sergi Velasco-de Andrés, María Catalá, Cristina Leyton-Pereira, Alejandra Lozano, Francisco Bosch, Elena |
| format |
artículo |
| topic_facet |
Scavenger receptors CD5 CD6 Immune response Cancer Autoimmunity Infections Natural selection Human genetics Single nucleotide polymorphisms |
| author |
Casadó-Llombart, Sergi Velasco-de Andrés, María Catalá, Cristina Leyton-Pereira, Alejandra Lozano, Francisco Bosch, Elena |
| author_sort |
Casadó-Llombart, Sergi |
| title |
Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6 |
| title_short |
Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6 |
| title_full |
Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6 |
| title_fullStr |
Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6 |
| title_full_unstemmed |
Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6 |
| title_sort |
contribution of evolutionary selected immune gene polymorphism to immune-related disorders: the case of lymphocyte scavenger receptors cd5 and cd6 |
| publisher |
Multidisciplinary Digital Publishing Institute |
| publishDate |
2021-05-18 |
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http://hdl.handle.net/10261/247770 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100003030 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003176 |
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dig-ibe-es-10261-2477702021-12-28T16:10:33Z Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6 Casadó-Llombart, Sergi Velasco-de Andrés, María Catalá, Cristina Leyton-Pereira, Alejandra Lozano, Francisco Bosch, Elena Ministerio de Economía y Competitividad (España) European Commission Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) Agència de Gestió d'Ajuts Universitaris i de Recerca Generalitat de Catalunya Ministerio de Educación, Cultura y Deporte (España) Agencia Nacional de Investigación y Desarrollo (Chile) Scavenger receptors CD5 CD6 Immune response Cancer Autoimmunity Infections Natural selection Human genetics Single nucleotide polymorphisms This article belongs to the Special Issue Scavenger Receptors in Inflammation. Pathogens are one of the main selective pressures that ancestral humans had to adapt to. Components of the immune response system have been preferential targets of natural selection in response to such pathogen-driven pressure. In turn, there is compelling evidence showing that positively selected immune gene variants conferring increased resistance to past or present infectious agents are today associated with increased risk for autoimmune or inflammatory disorders but decreased risk of cancer, the other side of the same coin. CD5 and CD6 are lymphocytic scavenger receptors at the interphase of the innate and adaptive immune responses since they are involved in both: (i) microbial-associated pattern recognition; and (ii) modulation of intracellular signals mediated by the clonotypic antigen-specific receptor present in T and B cells (TCR and BCR, respectively). Here, we review available information on CD5 and CD6 as targets of natural selection as well as on the role of CD5 and CD6 variation in autoimmunity and cancer. This research was funded by Spanish Ministerio de Economía y Competitividad (MINECO; SAF-2016-80535-R, PID2019-106658RB-I00 and PCIN-2015-070) co-financed by European Development Regional Fund (ERDF) “A way to achieve Europe”, Agencia Estatal de Investigación (AEI; PID2019-110933GB-I00/AEI/10.13039/501100011033 and CEX2018-000792-M) and Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR; 2017/SGR/1582 and 2017SGR00702) from Generalitat de Catalunya to F.L. and E.B. In addition, S.C.-L., M.V.-d.A., C.C. and A.L.-P. are recipients of fellowships from Ministerio de Educación, Cultura y Deporte (FPU15/02897) MINECO (BES-2014-069237; BES-2017-082107) and Chilean Agencia Nacional de Investigación y Desarrollo (ANID; 2018-72190154), respectively. Peer reviewed 2021-08-11T07:47:15Z 2021-08-11T07:47:15Z 2021-05-18 artículo http://purl.org/coar/resource_type/c_6501 International Journal of Molecular Sciences 22(10): 5315 (2021) 1661-6596 http://hdl.handle.net/10261/247770 10.3390/ijms22105315 1422-0067 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100003030 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003176 34070159 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF-2016-80535-R info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106658RB-I00 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PCIN-2015-070 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-110933GB-I00 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CEX2018-000792-M info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2013-46151-R Publisher's version https://doi.org/10.3390/ijms22105315 Sí open Multidisciplinary Digital Publishing Institute |