DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches

DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches

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Trabajo presentado en el Second IBE PhD Symposium, celebrado online el 4 y 5 de febrero de 2021.

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Main Authors: Ventós-Alfonso, Alba, Ylla, Guillem, Montañés, José Carlos, Bellés, Xavier
Format: comunicación de congreso biblioteca
Language:English
Published: 2021-02
Online Access:http://hdl.handle.net/10261/242576
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spelling dig-ibe-es-10261-2425762021-06-05T01:11:12Z DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches Ventós-Alfonso, Alba Ylla, Guillem Montañés, José Carlos Bellés, Xavier Trabajo presentado en el Second IBE PhD Symposium, celebrado online el 4 y 5 de febrero de 2021. The phenotypic effects of DNA methylation are not well understood. Recent studies pointed out that insects may be excellent models for DNA methylation comparative analyses, due to their great diversity of DNA methylation modes. Until now, however, analyses have focused on holometabolan species, like bees, beetles, wasps, and flies. We have studied DNA methylation in the hemimetabolan insect Blattella germanica. We found that an enzyme involved in DNA methylation, the DNA methyltransferase 1 (DNMT1), is expressed in early embryogenesis. RNAi experiments on DNMT1resulted in reduction of DNA methylation and impaired blastoderm formation. Moreover, reduced representation bisulfite sequencing data and transcriptomic analyses showed that methylated genes are highly expressed and associatedwith metabolism, whereas unmethylated genes are low expressed and related to signaling pathways. Interestingly, we found that methylated genes show less expression variability than unmethylated genes. Peer reviewed 2021-06-04T08:40:30Z 2021-06-04T08:40:30Z 2021-02 comunicación de congreso http://purl.org/coar/resource_type/c_5794 Second IBE PhD Symposium (2021) http://hdl.handle.net/10261/242576 en Sí open
institution IBE ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ibe-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IBE España
language English
description Trabajo presentado en el Second IBE PhD Symposium, celebrado online el 4 y 5 de febrero de 2021.
format comunicación de congreso
author Ventós-Alfonso, Alba
Ylla, Guillem
Montañés, José Carlos
Bellés, Xavier
spellingShingle Ventós-Alfonso, Alba
Ylla, Guillem
Montañés, José Carlos
Bellés, Xavier
DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches
author_facet Ventós-Alfonso, Alba
Ylla, Guillem
Montañés, José Carlos
Bellés, Xavier
author_sort Ventós-Alfonso, Alba
title DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches
title_short DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches
title_full DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches
title_fullStr DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches
title_full_unstemmed DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches
title_sort dnmt1 promotes genome methylation and early embryo development in cockroaches
publishDate 2021-02
url http://hdl.handle.net/10261/242576
work_keys_str_mv AT ventosalfonsoalba dnmt1promotesgenomemethylationandearlyembryodevelopmentincockroaches
AT yllaguillem dnmt1promotesgenomemethylationandearlyembryodevelopmentincockroaches
AT montanesjosecarlos dnmt1promotesgenomemethylationandearlyembryodevelopmentincockroaches
AT bellesxavier dnmt1promotesgenomemethylationandearlyembryodevelopmentincockroaches
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