Sex-biased patterns shaped the genetic history of Roma
The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous genetic studies based on genome-wide data and uniparental markers detected Roma founder events and West-Eurasian gene flow. However, to the best of our knowledge, it has not been assessed whether these demographic processes have equally affected both sexes in the population. The present study uses the largest and most comprehensive dataset of complete mitochondrial and Y chromosome Roma sequences to unravel the sex-biased patterns that have shaped their genetic history. The results show that the Roma maternal genetic pool carries a higher lineage diversity from South Asia, as opposed to a single paternal South Asian lineage. Nonetheless, the European gene flow events mainly occurred through the maternal lineages; however, a signal of this gene flow is also traceable in the paternal lineages. We also detect a higher female migration rate among European Roma groups. Altogether, these results suggest that sociocultural factors influenced the emergence of sex-biased genetic patterns at global and local scales in the Roma population through time.
Main Authors: | , , , , , , , , , , |
---|---|
Other Authors: | |
Format: | artículo biblioteca |
Published: |
Nature Publishing Group
2020-09-02
|
Subjects: | Genetic variation, |
Online Access: | http://hdl.handle.net/10261/236919 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-ibe-es-10261-236919 |
---|---|
record_format |
koha |
spelling |
dig-ibe-es-10261-2369192021-04-07T01:12:49Z Sex-biased patterns shaped the genetic history of Roma García-Fernández, Carla Font-Porterias, Neus Kučinskas, Vaidutis Sukarova Stefanovska, Emilija Pamjav, Horolma Makukh, Halyna Dobon, Begoña Bertranpetit, Jaume Netea, Mihai G. Calafell, Francesc Comas, David Ministerio de Economía y Competitividad (España) Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) European Commission Generalitat de Catalunya Genetic variation The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous genetic studies based on genome-wide data and uniparental markers detected Roma founder events and West-Eurasian gene flow. However, to the best of our knowledge, it has not been assessed whether these demographic processes have equally affected both sexes in the population. The present study uses the largest and most comprehensive dataset of complete mitochondrial and Y chromosome Roma sequences to unravel the sex-biased patterns that have shaped their genetic history. The results show that the Roma maternal genetic pool carries a higher lineage diversity from South Asia, as opposed to a single paternal South Asian lineage. Nonetheless, the European gene flow events mainly occurred through the maternal lineages; however, a signal of this gene flow is also traceable in the paternal lineages. We also detect a higher female migration rate among European Roma groups. Altogether, these results suggest that sociocultural factors influenced the emergence of sex-biased genetic patterns at global and local scales in the Roma population through time. Tis work was supported by the Spanish Ministry of Economy and Competitiveness (grant numbers CGL2016- 75389-P (MINEICO/FEDER, UE), PID2019-106485GB-I00 (MINEICO), and “Unidad María de Maeztu” (MDM-2014-0370) to DC and FC; and Agència de Gestió d’Ajuts Universitaris i de la Recerca (Generalitat de Catalunya, grant 2017SGR00702). NF-P was supported by a FPU17/03501 fellowship 2021-04-06T15:10:04Z 2021-04-06T15:10:04Z 2020-09-02 2021-04-06T15:10:04Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1038/s41598-020-71066-y e-issn: 2045-2322 Scientific Reports 10: 14464 (2020) http://hdl.handle.net/10261/236919 10.1038/s41598-020-71066-y http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2016-75389-P info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106485GB-I00 PID2019-106485GB-I00/AEI/10.13039/501100011033 Publisher's version http://dx.doi.org/10.1038/s41598-020-71066-y Sí open Nature Publishing Group |
institution |
IBE ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-ibe-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del IBE España |
topic |
Genetic variation Genetic variation |
spellingShingle |
Genetic variation Genetic variation García-Fernández, Carla Font-Porterias, Neus Kučinskas, Vaidutis Sukarova Stefanovska, Emilija Pamjav, Horolma Makukh, Halyna Dobon, Begoña Bertranpetit, Jaume Netea, Mihai G. Calafell, Francesc Comas, David Sex-biased patterns shaped the genetic history of Roma |
description |
The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged into ethnolinguistically distinct migrant groups that spread across the continent. Previous genetic studies based on genome-wide data and uniparental markers detected Roma founder events and West-Eurasian gene flow. However, to the best of our knowledge, it has not been assessed whether these demographic processes have equally affected both sexes in the population. The present study uses the largest and most comprehensive dataset of complete mitochondrial and Y chromosome Roma sequences to unravel the sex-biased patterns that have shaped their genetic history. The results show that the Roma maternal genetic pool carries a higher lineage diversity from South Asia, as opposed to a single paternal South Asian lineage. Nonetheless, the European gene flow events mainly occurred through the maternal lineages; however, a signal of this gene flow is also traceable in the paternal lineages. We also detect a higher female migration rate among European Roma groups. Altogether, these results suggest that sociocultural factors influenced the emergence of sex-biased genetic patterns at global and local scales in the Roma population through time. |
author2 |
Ministerio de Economía y Competitividad (España) |
author_facet |
Ministerio de Economía y Competitividad (España) García-Fernández, Carla Font-Porterias, Neus Kučinskas, Vaidutis Sukarova Stefanovska, Emilija Pamjav, Horolma Makukh, Halyna Dobon, Begoña Bertranpetit, Jaume Netea, Mihai G. Calafell, Francesc Comas, David |
format |
artículo |
topic_facet |
Genetic variation |
author |
García-Fernández, Carla Font-Porterias, Neus Kučinskas, Vaidutis Sukarova Stefanovska, Emilija Pamjav, Horolma Makukh, Halyna Dobon, Begoña Bertranpetit, Jaume Netea, Mihai G. Calafell, Francesc Comas, David |
author_sort |
García-Fernández, Carla |
title |
Sex-biased patterns shaped the genetic history of Roma |
title_short |
Sex-biased patterns shaped the genetic history of Roma |
title_full |
Sex-biased patterns shaped the genetic history of Roma |
title_fullStr |
Sex-biased patterns shaped the genetic history of Roma |
title_full_unstemmed |
Sex-biased patterns shaped the genetic history of Roma |
title_sort |
sex-biased patterns shaped the genetic history of roma |
publisher |
Nature Publishing Group |
publishDate |
2020-09-02 |
url |
http://hdl.handle.net/10261/236919 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 |
work_keys_str_mv |
AT garciafernandezcarla sexbiasedpatternsshapedthegenetichistoryofroma AT fontporteriasneus sexbiasedpatternsshapedthegenetichistoryofroma AT kucinskasvaidutis sexbiasedpatternsshapedthegenetichistoryofroma AT sukarovastefanovskaemilija sexbiasedpatternsshapedthegenetichistoryofroma AT pamjavhorolma sexbiasedpatternsshapedthegenetichistoryofroma AT makukhhalyna sexbiasedpatternsshapedthegenetichistoryofroma AT dobonbegona sexbiasedpatternsshapedthegenetichistoryofroma AT bertranpetitjaume sexbiasedpatternsshapedthegenetichistoryofroma AT neteamihaig sexbiasedpatternsshapedthegenetichistoryofroma AT calafellfrancesc sexbiasedpatternsshapedthegenetichistoryofroma AT comasdavid sexbiasedpatternsshapedthegenetichistoryofroma |
_version_ |
1777668785659969536 |