Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates

Juan, David; García-Pérez, Raquel; Esteller-Cucala, Paula; Mas, Glòria; Lobón, Irene; Di Carlo, Valerio; Riera, Meritxell; Kuhlwilm, Martin; Navarro, Arcadi; Blancher, Antoine; Croce, Luciano di; Gómez-Skarmeta, José Luis; Marqués-Bonet, Tomàs

Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates

Trabajo presentado en el VII Congress of the Spanish Society for Evolutionary Biology / VII Congreso de la Sociedad Española de Biología Evolutiva (SESBE VII), celebrado en Sevilla del 5 al 7 de febrero de 2020.

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Main Authors:	Juan, David, García-Pérez, Raquel, Esteller-Cucala, Paula, Mas, Glòria, Lobón, Irene, Di Carlo, Valerio, Riera, Meritxell, Kuhlwilm, Martin, Navarro, Arcadi, Blancher, Antoine, Croce, Luciano di, Gómez-Skarmeta, José Luis, Marqués-Bonet, Tomàs
Format:	comunicación de congreso biblioteca
Published:	2020-02-07
Online Access:	http://hdl.handle.net/10261/236792
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id	dig-ibe-es-10261-236792
record_format	koha
spelling	dig-ibe-es-10261-2367922021-08-27T06:25:08Z Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates Juan, David García-Pérez, Raquel Esteller-Cucala, Paula Mas, Glòria Lobón, Irene Di Carlo, Valerio Riera, Meritxell Kuhlwilm, Martin Navarro, Arcadi Blancher, Antoine Croce, Luciano di Gómez-Skarmeta, José Luis Marqués-Bonet, Tomàs Trabajo presentado en el VII Congress of the Spanish Society for Evolutionary Biology / VII Congreso de la Sociedad Española de Biología Evolutiva (SESBE VII), celebrado en Sevilla del 5 al 7 de febrero de 2020. Genes undergoing substantial evolutionary shifts in their expression profiles are often modulated by critical epigenomic changes that are among the primary targets of selection in evolution. Here, we investigate the evolution of epigenetic regulatory activities and their interplay with gene expression in human and non-human primate lineages. We extensively profiled a new panel of human and non-human primate lymphoblastoid cell lines using a variety of NGS techniques and integrated genome-wide chromatin contact maps to define gene regulatory architectures. We observe that epigenetic and sequence conservation are coupled in regulatory elements and reflect the impact of their activity on gene expression. The addition or removal of strong and poised promoters and intragenic enhancers is frequent in gene expression changes during recent primate evolution. In contrast, novel human-specific weak intragenic enhancers, dormant in our cell lines, have emerged in genes showing signals of recent adaptive selection, suggesting that they echo important regulatory innovations in other cell types. Among the genes targeted by these regulatory innovations, we find key candidate drivers of recently evolved human traits, such as FOXP2 or ROBO1 for speech and language acquisition, and PALMD for neocortex expansion, thus highlighting the importance of regulatory changes in human evolution. 2021-04-06T08:10:02Z 2021-04-06T08:10:02Z 2020-02-07 2021-04-06T08:10:02Z comunicación de congreso http://purl.org/coar/resource_type/c_5794 VII Congress of the Spanish Society for Evolutionary Biology (2020) http://hdl.handle.net/10261/236792 Sí open
institution	IBE ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-ibe-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del IBE España
description	Trabajo presentado en el VII Congress of the Spanish Society for Evolutionary Biology / VII Congreso de la Sociedad Española de Biología Evolutiva (SESBE VII), celebrado en Sevilla del 5 al 7 de febrero de 2020.
format	comunicación de congreso
author	Juan, David García-Pérez, Raquel Esteller-Cucala, Paula Mas, Glòria Lobón, Irene Di Carlo, Valerio Riera, Meritxell Kuhlwilm, Martin Navarro, Arcadi Blancher, Antoine Croce, Luciano di Gómez-Skarmeta, José Luis Marqués-Bonet, Tomàs
spellingShingle	Juan, David García-Pérez, Raquel Esteller-Cucala, Paula Mas, Glòria Lobón, Irene Di Carlo, Valerio Riera, Meritxell Kuhlwilm, Martin Navarro, Arcadi Blancher, Antoine Croce, Luciano di Gómez-Skarmeta, José Luis Marqués-Bonet, Tomàs Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates
author_facet	Juan, David García-Pérez, Raquel Esteller-Cucala, Paula Mas, Glòria Lobón, Irene Di Carlo, Valerio Riera, Meritxell Kuhlwilm, Martin Navarro, Arcadi Blancher, Antoine Croce, Luciano di Gómez-Skarmeta, José Luis Marqués-Bonet, Tomàs
author_sort	Juan, David
title	Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates
title_short	Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates
title_full	Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates
title_fullStr	Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates
title_full_unstemmed	Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates
title_sort	gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates
publishDate	2020-02-07
url	http://hdl.handle.net/10261/236792
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Gene regulatory architectures dissect the evolutionary dynamics of regulatory elements in humans and non-human primates

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