The genomic footprints of the fall and recovery of the crested ibis
Feng et al. use whole-genome sequencing of contemporary and historic crested ibis, an iconic endangered bird species, to explore how their genetic diversity has changed through time. Their analyses reveal the roles of genetic drift and intensive inbreeding on the loss of genetic diversity in today's population.Human-induced environmental change and habitat fragmentation pose major threats to biodiversity and require active conservation efforts to mitigate their consequences. Genetic rescue through translocation and the introduction of variation into imperiled populations has been argued as a powerful means to preserve, or even increase, the genetic diversity and evolutionary potential of endangered species [1–4]. However, factors such as outbreeding depression [5, 6] and a reduction in available genetic diversity render the success of such approaches uncertain. An improved evaluation of the consequence of genetic restoration requires knowledge of temporal changes to genetic diversity before and after the advent of management programs. To provide such information, a growing number of studies have included small numbers of genomic loci extracted from historic and even ancient specimens [7, 8]. We extend this approach to its natural conclusion, by characterizing the complete genomic sequences of modern and historic population samples of the crested ibis (Nipponia nippon), an endangered bird that is perhaps the most successful example of how conservation effort has brought a species back from the brink of extinction. Though its once tiny population has today recovered to >2,000 individuals [9], this process was accompanied by almost half of ancestral loss of genetic variation and high deleterious mutation load. We furthermore show how genetic drift coupled to inbreeding following the population bottleneck has largely purged the ancient polymorphisms from the current population. In conclusion, we demonstrate the unique promise of exploiting genomic information held within museum samples for conservation and ecological research.
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Other Authors: | |
Format: | artículo biblioteca |
Published: |
Elsevier
2019-01-21
|
Subjects: | Conservation genomics, Population genomics, Endangered species, Extinction, demography, Inbreeding, Mutation load, genetic recovery, Ancient genomics, Ornithology, |
Online Access: | http://hdl.handle.net/10261/206194 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100001659 http://dx.doi.org/10.13039/501100002367 http://dx.doi.org/10.13039/501100002808 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-ibe-es-10261-206194 |
---|---|
record_format |
koha |
institution |
IBE ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-ibe-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del IBE España |
topic |
Conservation genomics Population genomics Endangered species Extinction demography Inbreeding Mutation load genetic recovery Ancient genomics Ornithology Conservation genomics Population genomics Endangered species Extinction demography Inbreeding Mutation load genetic recovery Ancient genomics Ornithology |
spellingShingle |
Conservation genomics Population genomics Endangered species Extinction demography Inbreeding Mutation load genetic recovery Ancient genomics Ornithology Conservation genomics Population genomics Endangered species Extinction demography Inbreeding Mutation load genetic recovery Ancient genomics Ornithology Feng, Shaohong Fang, Qi Barnett, Ross Li, Cai Han, Sojung Kuhlwilm, Martin Zhou, Long Pan, Hailin Deng, Yuan Chen, Guangji Gamauf, Anita Woog, Friederike Prys-Jones, Robert Marqués-Bonet, Tomàs Gilbert, M. Thomas P. Zhang, Guojie The genomic footprints of the fall and recovery of the crested ibis |
description |
Feng et al. use whole-genome sequencing of contemporary and historic crested ibis, an iconic endangered bird species, to explore how their genetic diversity has changed through time. Their analyses reveal the roles of genetic drift and intensive inbreeding on the loss of genetic diversity in today's population.Human-induced environmental change and habitat fragmentation pose major threats to biodiversity and require active conservation efforts to mitigate their consequences. Genetic rescue through translocation and the introduction of variation into imperiled populations has been argued as a powerful means to preserve, or even increase, the genetic diversity and evolutionary potential of endangered species [1–4]. However, factors such as outbreeding depression [5, 6] and a reduction in available genetic diversity render the success of such approaches uncertain. An improved evaluation of the consequence of genetic restoration requires knowledge of temporal changes to genetic diversity before and after the advent of management programs. To provide such information, a growing number of studies have included small numbers of genomic loci extracted from historic and even ancient specimens [7, 8]. We extend this approach to its natural conclusion, by characterizing the complete genomic sequences of modern and historic population samples of the crested ibis (Nipponia nippon), an endangered bird that is perhaps the most successful example of how conservation effort has brought a species back from the brink of extinction. Though its once tiny population has today recovered to >2,000 individuals [9], this process was accompanied by almost half of ancestral loss of genetic variation and high deleterious mutation load. We furthermore show how genetic drift coupled to inbreeding following the population bottleneck has largely purged the ancient polymorphisms from the current population. In conclusion, we demonstrate the unique promise of exploiting genomic information held within museum samples for conservation and ecological research. |
author2 |
Chinese Academy of Sciences |
author_facet |
Chinese Academy of Sciences Feng, Shaohong Fang, Qi Barnett, Ross Li, Cai Han, Sojung Kuhlwilm, Martin Zhou, Long Pan, Hailin Deng, Yuan Chen, Guangji Gamauf, Anita Woog, Friederike Prys-Jones, Robert Marqués-Bonet, Tomàs Gilbert, M. Thomas P. Zhang, Guojie |
format |
artículo |
topic_facet |
Conservation genomics Population genomics Endangered species Extinction demography Inbreeding Mutation load genetic recovery Ancient genomics Ornithology |
author |
Feng, Shaohong Fang, Qi Barnett, Ross Li, Cai Han, Sojung Kuhlwilm, Martin Zhou, Long Pan, Hailin Deng, Yuan Chen, Guangji Gamauf, Anita Woog, Friederike Prys-Jones, Robert Marqués-Bonet, Tomàs Gilbert, M. Thomas P. Zhang, Guojie |
author_sort |
Feng, Shaohong |
title |
The genomic footprints of the fall and recovery of the crested ibis |
title_short |
The genomic footprints of the fall and recovery of the crested ibis |
title_full |
The genomic footprints of the fall and recovery of the crested ibis |
title_fullStr |
The genomic footprints of the fall and recovery of the crested ibis |
title_full_unstemmed |
The genomic footprints of the fall and recovery of the crested ibis |
title_sort |
genomic footprints of the fall and recovery of the crested ibis |
publisher |
Elsevier |
publishDate |
2019-01-21 |
url |
http://hdl.handle.net/10261/206194 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100001659 http://dx.doi.org/10.13039/501100002367 http://dx.doi.org/10.13039/501100002808 |
work_keys_str_mv |
AT fengshaohong thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT fangqi thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT barnettross thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT licai thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT hansojung thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT kuhlwilmmartin thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT zhoulong thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT panhailin thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT dengyuan thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT chenguangji thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT gamaufanita thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT woogfriederike thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT prysjonesrobert thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT marquesbonettomas thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT gilbertmthomasp thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT zhangguojie thegenomicfootprintsofthefallandrecoveryofthecrestedibis AT fengshaohong genomicfootprintsofthefallandrecoveryofthecrestedibis AT fangqi genomicfootprintsofthefallandrecoveryofthecrestedibis AT barnettross genomicfootprintsofthefallandrecoveryofthecrestedibis AT licai genomicfootprintsofthefallandrecoveryofthecrestedibis AT hansojung genomicfootprintsofthefallandrecoveryofthecrestedibis AT kuhlwilmmartin genomicfootprintsofthefallandrecoveryofthecrestedibis AT zhoulong genomicfootprintsofthefallandrecoveryofthecrestedibis AT panhailin genomicfootprintsofthefallandrecoveryofthecrestedibis AT dengyuan genomicfootprintsofthefallandrecoveryofthecrestedibis AT chenguangji genomicfootprintsofthefallandrecoveryofthecrestedibis AT gamaufanita genomicfootprintsofthefallandrecoveryofthecrestedibis AT woogfriederike genomicfootprintsofthefallandrecoveryofthecrestedibis AT prysjonesrobert genomicfootprintsofthefallandrecoveryofthecrestedibis AT marquesbonettomas genomicfootprintsofthefallandrecoveryofthecrestedibis AT gilbertmthomasp genomicfootprintsofthefallandrecoveryofthecrestedibis AT zhangguojie genomicfootprintsofthefallandrecoveryofthecrestedibis |
_version_ |
1777668743840661504 |
spelling |
dig-ibe-es-10261-2061942021-12-27T15:32:24Z The genomic footprints of the fall and recovery of the crested ibis Feng, Shaohong Fang, Qi Barnett, Ross Li, Cai Han, Sojung Kuhlwilm, Martin Zhou, Long Pan, Hailin Deng, Yuan Chen, Guangji Gamauf, Anita Woog, Friederike Prys-Jones, Robert Marqués-Bonet, Tomàs Gilbert, M. Thomas P. Zhang, Guojie Chinese Academy of Sciences Carlsberg Foundation European Research Council Ministerio de Ciencia, Innovación y Universidades (España) European Commission Fundación "la Caixa" Generalitat de Catalunya German Research Foundation Conservation genomics Population genomics Endangered species Extinction demography Inbreeding Mutation load genetic recovery Ancient genomics Ornithology Feng et al. use whole-genome sequencing of contemporary and historic crested ibis, an iconic endangered bird species, to explore how their genetic diversity has changed through time. Their analyses reveal the roles of genetic drift and intensive inbreeding on the loss of genetic diversity in today's population.Human-induced environmental change and habitat fragmentation pose major threats to biodiversity and require active conservation efforts to mitigate their consequences. Genetic rescue through translocation and the introduction of variation into imperiled populations has been argued as a powerful means to preserve, or even increase, the genetic diversity and evolutionary potential of endangered species [1–4]. However, factors such as outbreeding depression [5, 6] and a reduction in available genetic diversity render the success of such approaches uncertain. An improved evaluation of the consequence of genetic restoration requires knowledge of temporal changes to genetic diversity before and after the advent of management programs. To provide such information, a growing number of studies have included small numbers of genomic loci extracted from historic and even ancient specimens [7, 8]. We extend this approach to its natural conclusion, by characterizing the complete genomic sequences of modern and historic population samples of the crested ibis (Nipponia nippon), an endangered bird that is perhaps the most successful example of how conservation effort has brought a species back from the brink of extinction. Though its once tiny population has today recovered to >2,000 individuals [9], this process was accompanied by almost half of ancestral loss of genetic variation and high deleterious mutation load. We furthermore show how genetic drift coupled to inbreeding following the population bottleneck has largely purged the ancient polymorphisms from the current population. In conclusion, we demonstrate the unique promise of exploiting genomic information held within museum samples for conservation and ecological research. This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences (XDB31020000, XDB13000000), Carlsberg Foundation grant to G.Z. (CF16-0663), ERC Consolidator Grant 681396 ‘Extinction Genomics’ (M.T.P.G.), BFU2017-86471-P (MINECO/FEDER, UE) (T.M.-B.), U01 MH106874 grant (T.M.-B.), Howard Hughes International Early Career (T.M.-B.), Obra Social “La Caixa” and Secretaria d’Universitats i Recerca (T.M.-B.), CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (T.M.-B.), and Deutsche Forschungsgemeinschaft (DFG) fellowship (KU 3467/1-1) (M.K.). 2020-04-02T07:04:26Z 2020-04-02T07:04:26Z 2019-01-21 2020-04-02T07:04:26Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.cub.2018.12.008 issn: 0960-9822 e-issn: 1879-0445 Current Biology 29(2): 340-349.e7 (2019) http://hdl.handle.net/10261/206194 10.1016/j.cub.2018.12.008 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100001659 http://dx.doi.org/10.13039/501100002367 http://dx.doi.org/10.13039/501100002808 30639104 #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/681396 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BFU2017-86471-P BFU2017-86471-P/AEI/10.13039/501100011033 Publisher's version http://doi.org/10.1016/j.cub.2018.12.008 Sí open Elsevier |