Gene connectivity and enzyme evolution in the human metabolic network
[Background] Determining the factors involved in the likelihood of a gene being under adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an evolutionary analysis of the human metabolic genes to explore the associations between network structure and the presence and strength of natural selection in the genes whose products are involved in metabolism. Purifying and positive selection are estimated at interspecific (among mammals) and intraspecific (among human populations) levels, and the connections between enzymatic reactions are differentiated between incoming (in-degree) and outgoing (out-degree) links.
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| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | artículo biblioteca |
| Published: |
BioMed Central
2019-09-03
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| Subjects: | Network topology, Degree, Connectivity, Metabolism, Enzymes, Positive selection, Purifying selection, |
| Online Access: | http://hdl.handle.net/10261/206076 http://dx.doi.org/10.13039/501100003176 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003329 |
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