Cellular partners of the telomeric retrotransposons in Drosophila melanogaster

Cellular partners of the telomeric retrotransposons in Drosophila melanogaster

Trabajo presentado en el 23rd European Drosophila Research Congress (EDRC 2013), celebrado en Barcelona del 16 al 19 de octubre de 2013.

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Main Authors: Lopez-Panades, Elisenda, Casacuberta, Elena
Format: póster de congreso biblioteca
Language:English
Published: 2013-10
Online Access:http://hdl.handle.net/10261/157011
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spelling dig-ibe-es-10261-1570112018-09-27T07:42:46Z Cellular partners of the telomeric retrotransposons in Drosophila melanogaster Lopez-Panades, Elisenda Casacuberta, Elena Trabajo presentado en el 23rd European Drosophila Research Congress (EDRC 2013), celebrado en Barcelona del 16 al 19 de octubre de 2013. Telomere length is involved in processes like aging, tumorogenesis and genome stability and needs to be tightly regulated. Instead of telomerase, Drosophila uses three non-LTR retrotransposons, HeT-A, TART and TAHRE, (HTT), which transpose exclusively to telomeres to maintain telomere length. In Drosophila, telomere biology is based on a complex equilibrium between terminal transposition whenever telomere replication is needed, and tight control of telomere transposition in order to preserve genome stability. In order to understand the basis of this equilibrium, we have aimed to study the composition and life cycle of the telomere ribonucleoprotein (RNP). We have studied the localization in different tissues of the components of the telomere RNP (HTT proteins and mRNAs), as well as interacting partners of the telomere RNP that we have identified (Lost, Tral and NAP-1). We show that Nap1 is able to directly interact with HeT-A Gag, the telomere protein in charge of telomere targeting. Nap1 also interacts with different chromatin remodeling complexes like NURF and HP2. The direct interaction of these proteins with HeT-A Gag suggests a mechanism to target these chromatin remodeling complexes to the array of the telomeric retrotransposons, the HTT array. On the other hand, Lost and Tral are important players in the protection, processing, transport and localization of different mRNAs involved in germ line development. We are currently investigating the nature of the interaction between the telomere RNP and the Lost and Tral proteins. No 2017-11-06T10:31:11Z 2017-11-06T10:31:11Z 2013-10 póster de congreso http://purl.org/coar/resource_type/c_6670 23rd European Drosophila Research Congress (2013) http://hdl.handle.net/10261/157011 en No none
institution IBE ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ibe-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IBE España
language English
description Trabajo presentado en el 23rd European Drosophila Research Congress (EDRC 2013), celebrado en Barcelona del 16 al 19 de octubre de 2013.
format póster de congreso
author Lopez-Panades, Elisenda
Casacuberta, Elena
spellingShingle Lopez-Panades, Elisenda
Casacuberta, Elena
Cellular partners of the telomeric retrotransposons in Drosophila melanogaster
author_facet Lopez-Panades, Elisenda
Casacuberta, Elena
author_sort Lopez-Panades, Elisenda
title Cellular partners of the telomeric retrotransposons in Drosophila melanogaster
title_short Cellular partners of the telomeric retrotransposons in Drosophila melanogaster
title_full Cellular partners of the telomeric retrotransposons in Drosophila melanogaster
title_fullStr Cellular partners of the telomeric retrotransposons in Drosophila melanogaster
title_full_unstemmed Cellular partners of the telomeric retrotransposons in Drosophila melanogaster
title_sort cellular partners of the telomeric retrotransposons in drosophila melanogaster
publishDate 2013-10
url http://hdl.handle.net/10261/157011
work_keys_str_mv AT lopezpanadeselisenda cellularpartnersofthetelomericretrotransposonsindrosophilamelanogaster
AT casacubertaelena cellularpartnersofthetelomericretrotransposonsindrosophilamelanogaster
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