A genomic study of the contribution of DNA methylation to regulatory evolution in primates

A genomic study of the contribution of DNA methylation to regulatory evolution in primates

Trabajo presentado en la Annual meeting of the Society for Molecular Biology and Evolution (SMBE 2015), celebrado en Viena del 12 al 16 de julio de 2015.

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Main Authors: Roux, Julien, Hernando-Herraez, Irene, Banovich, Nick, García-Pérez, Raquel, Chavarria, Claudia, Mitrano, Amy, Pritchard, Jonathan, Marqués-Bonet, Tomàs, Gilad, Yoav
Format: comunicación de congreso biblioteca
Language:English
Published: 2015-07
Online Access:http://hdl.handle.net/10261/153889
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spelling dig-ibe-es-10261-1538892018-10-03T07:36:46Z A genomic study of the contribution of DNA methylation to regulatory evolution in primates Roux, Julien Hernando-Herraez, Irene Banovich, Nick García-Pérez, Raquel Chavarria, Claudia Mitrano, Amy Pritchard, Jonathan Marqués-Bonet, Tomàs Gilad, Yoav Trabajo presentado en la Annual meeting of the Society for Molecular Biology and Evolution (SMBE 2015), celebrado en Viena del 12 al 16 de julio de 2015. A long-standing hypothesis is that changes in gene regulation play an important role in adaptive evolution, notably in primates. Yet, in spite of the evidence accumulated in the past decade that regulatory changes contribute to many species-specific adaptations, we still know remarkably little about the mechanisms of regulatory evolu tion. In this study we focused on DNA methylation, an epigenetic mechanism whose contribution to the evolution of gene expression remains unclear. To interrogate the methylation status of the vast majority of cytosines in the genome, we performed whole-genome bisulfite conversion followed by high-throughput sequencing across 4 tissues (heart, kidney, liver and lung) in 3 primate species (human, chimpanzee and macaque). In parallel, we collected gene expression profiles using RNA-seq from the same tissue sam ples, allowing us to perform a high resolution scan for genes and pathways whose regulation evolved under natural selection. We integrated these datasets to characterize better the genome features whose methylation status leads to expression changes, and we developed a statistical model to quantify the proportion of variation in gene expression levels across tissues and species. We discovered that, in contrast to the confirmed negative association between gene expression and methylation changes across tissu es, the correlation was greatly reduced across species. Our study questions the importance of epigenetic modifications as a mechanism causing regulatory changes and adaptations in primates. No 2017-08-07T08:49:38Z 2017-08-07T08:49:38Z 2015-07 comunicación de congreso http://purl.org/coar/resource_type/c_5794 Annual meeting of the Society for Molecular Biology and Evolution (2015) http://hdl.handle.net/10261/153889 en Sí none
institution IBE ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ibe-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IBE España
language English
description Trabajo presentado en la Annual meeting of the Society for Molecular Biology and Evolution (SMBE 2015), celebrado en Viena del 12 al 16 de julio de 2015.
format comunicación de congreso
author Roux, Julien
Hernando-Herraez, Irene
Banovich, Nick
García-Pérez, Raquel
Chavarria, Claudia
Mitrano, Amy
Pritchard, Jonathan
Marqués-Bonet, Tomàs
Gilad, Yoav
spellingShingle Roux, Julien
Hernando-Herraez, Irene
Banovich, Nick
García-Pérez, Raquel
Chavarria, Claudia
Mitrano, Amy
Pritchard, Jonathan
Marqués-Bonet, Tomàs
Gilad, Yoav
A genomic study of the contribution of DNA methylation to regulatory evolution in primates
author_facet Roux, Julien
Hernando-Herraez, Irene
Banovich, Nick
García-Pérez, Raquel
Chavarria, Claudia
Mitrano, Amy
Pritchard, Jonathan
Marqués-Bonet, Tomàs
Gilad, Yoav
author_sort Roux, Julien
title A genomic study of the contribution of DNA methylation to regulatory evolution in primates
title_short A genomic study of the contribution of DNA methylation to regulatory evolution in primates
title_full A genomic study of the contribution of DNA methylation to regulatory evolution in primates
title_fullStr A genomic study of the contribution of DNA methylation to regulatory evolution in primates
title_full_unstemmed A genomic study of the contribution of DNA methylation to regulatory evolution in primates
title_sort genomic study of the contribution of dna methylation to regulatory evolution in primates
publishDate 2015-07
url http://hdl.handle.net/10261/153889
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