Fitness effects of a transposable element insertion depend on environmental conditions in Drosophila melanogaster
Trabajo presentado en la XIII Jornada de Biologia Evolutiva, celebrada en Barcelona el 2 de julio de 2013.
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dig-ibe-es-10261-1537682018-10-03T07:01:44Z Fitness effects of a transposable element insertion depend on environmental conditions in Drosophila melanogaster Guio, Lain González Pérez, Josefa Trabajo presentado en la XIII Jornada de Biologia Evolutiva, celebrada en Barcelona el 2 de julio de 2013. Understanding how adaptation works is one of the major questions in Evolutionary Biology. Towards answering this question, we identified recent Transposable Element (TE)-induced adaptations in Drosophila melanogaster and we are currently connecting them to their molecular mechanisms and fitness effects. Specifically, the TE insertion named Bari-Jheh, is present at high frequency, but not fixed, in all the populations analyzed. Bari-Jheh is inserted in the intergenic region between Jheh2 and Jheh3 genes encoding for Juvenile Hormone Epoxy Hydrolase. Previous results show that Bari-Jheh is associated with a downregulation of the expression of Jheh2 and Jheh3 genes. Furthermore, Bari-Jheh is associated with reduced viability and extended developmental time that probably represent the cost of selection of this insertion. To identify the adaptive effect of this TE, we analyzed its sequence and we found two Antioxidant Response Elements (AREs) suggesting that Bari-Jheh might be involved in oxidative stress response. We indeed found that under ecologically relevant oxidative stress conditions the TE is associated with an increased expression of Jheh1 and Jheh2 (t-test p< 0.05) and that flies with the insertion show a higher survival rate compared to flies without the insertion (Logrank test: p<< 0.001). Our results suggest that TEs could play an important role in oxidative stress response not only in Drosophila but also in other organisms since the ARE signaling pathway is highly conserved across species. Our results also emphasize the need to explore several phenotypes in different environmental conditions in order to fully characterize the effects of an adaptive mutation. No 2017-08-01T12:21:16Z 2017-08-01T12:21:16Z 2013-07 póster de congreso http://purl.org/coar/resource_type/c_6670 XIII Jornada de Biologia Evolutiva (2013) http://hdl.handle.net/10261/153768 en Sí none |
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| description |
Trabajo presentado en la XIII Jornada de Biologia Evolutiva, celebrada en Barcelona el 2 de julio de 2013. |
| format |
póster de congreso |
| author |
Guio, Lain González Pérez, Josefa |
| spellingShingle |
Guio, Lain González Pérez, Josefa Fitness effects of a transposable element insertion depend on environmental conditions in Drosophila melanogaster |
| author_facet |
Guio, Lain González Pérez, Josefa |
| author_sort |
Guio, Lain |
| title |
Fitness effects of a transposable element insertion depend on environmental conditions in Drosophila melanogaster |
| title_short |
Fitness effects of a transposable element insertion depend on environmental conditions in Drosophila melanogaster |
| title_full |
Fitness effects of a transposable element insertion depend on environmental conditions in Drosophila melanogaster |
| title_fullStr |
Fitness effects of a transposable element insertion depend on environmental conditions in Drosophila melanogaster |
| title_full_unstemmed |
Fitness effects of a transposable element insertion depend on environmental conditions in Drosophila melanogaster |
| title_sort |
fitness effects of a transposable element insertion depend on environmental conditions in drosophila melanogaster |
| publishDate |
2013-07 |
| url |
http://hdl.handle.net/10261/153768 |
| work_keys_str_mv |
AT guiolain fitnesseffectsofatransposableelementinsertiondependonenvironmentalconditionsindrosophilamelanogaster AT gonzalezperezjosefa fitnesseffectsofatransposableelementinsertiondependonenvironmentalconditionsindrosophilamelanogaster |
| _version_ |
1777668698404814848 |