Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project

Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project

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Trabajo presentado en la 4th Meeting of the Spanish Society of the Evolutionary Biology (SESBE 2013) celebrada en Barcelona del 27 al 29 de noviembre de 2013.

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Main Authors: Santpere, Gabriel, Darré-Toulemonde, Fleur, Blanco, Soledad, Alcamí, Antonio, Villoslada, Pablo, Albà, M. Mar, Navarro, Arcadi
Format: comunicación de congreso biblioteca
Language:English
Published: 2013-11
Online Access:http://hdl.handle.net/10261/153405
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spelling dig-ibe-es-10261-1534052018-10-03T07:44:32Z Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project Santpere, Gabriel Darré-Toulemonde, Fleur Blanco, Soledad Alcamí, Antonio Villoslada, Pablo Albà, M. Mar Navarro, Arcadi Trabajo presentado en la 4th Meeting of the Spanish Society of the Evolutionary Biology (SESBE 2013) celebrada en Barcelona del 27 al 29 de noviembre de 2013. Most people in the world (~90%) are infected by the Epstein-Barr virus (EBV), which establishes itself permanently in B-cells. Infection by EBV is related to a number of diseases including infectious mononucleosis, multiple sclerosis and different types of cancer. So far, only seven complete EBV strains have been described, all of them coming from donors presenting EBV-related diseases. To perform a detailed comparative genomics analysis of EBV including, for the first time, EBV strains derived from healthy individuals we reconstructed EBV sequences infecting lymphoblastoid cell lines (LCLs) from the 1000 Genomes Project. Since strain B95-8 was used to transform B-cells to obtain LCLs, it is always present, but a specific deletion in its genome sets it apart from natural EBV strains. After studying hundreds of individuals, we determined the presence of natural EBV in at least 10 of them and obtained a set of variants specific to wild-type EBV. By mapping the natural EBV reads into the EBV reference genome (NC007605) we constructed wild-type viral genomes from three individuals. Analysis of all the available sequences reveals a complex history of recombination among EBV strains and that latency genes harbour more nucleotide diversity than lytic genes. Six out of nine latency-related genes present the molecular signature of positive selection, suggesting rapid host-parasite co-evolution. Peer reviewed 2017-07-24T07:18:47Z 2017-07-24T07:18:47Z 2013-11 comunicación de congreso http://purl.org/coar/resource_type/c_5794 4th Meeting of the Spanish Society for Evolutionary Biology (2013) http://hdl.handle.net/10261/153405 en Sí none
institution IBE ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-ibe-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IBE España
language English
description Trabajo presentado en la 4th Meeting of the Spanish Society of the Evolutionary Biology (SESBE 2013) celebrada en Barcelona del 27 al 29 de noviembre de 2013.
format comunicación de congreso
author Santpere, Gabriel
Darré-Toulemonde, Fleur
Blanco, Soledad
Alcamí, Antonio
Villoslada, Pablo
Albà, M. Mar
Navarro, Arcadi
spellingShingle Santpere, Gabriel
Darré-Toulemonde, Fleur
Blanco, Soledad
Alcamí, Antonio
Villoslada, Pablo
Albà, M. Mar
Navarro, Arcadi
Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project
author_facet Santpere, Gabriel
Darré-Toulemonde, Fleur
Blanco, Soledad
Alcamí, Antonio
Villoslada, Pablo
Albà, M. Mar
Navarro, Arcadi
author_sort Santpere, Gabriel
title Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project
title_short Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project
title_full Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project
title_fullStr Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project
title_full_unstemmed Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project
title_sort genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project
publishDate 2013-11
url http://hdl.handle.net/10261/153405
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