Premetazoan Origin of the Hippo Signaling Pathway
Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa. Through comparative analyses of recently sequenced holozoan genomes, we show that Hippo pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals. Remarkably, functional analysis of Hippo components of the amoeboid holozoan Capsaspora owczarzaki, performed in Drosophila melanogaster, demonstrate that the growth-regulatory activity of the Hippo pathway is conserved in this unicellular lineage. Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa. © 2012 The Authors.
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2012-01-26
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dig-ibe-es-10261-1155322021-12-27T15:34:21Z Premetazoan Origin of the Hippo Signaling Pathway Sebé-Pedrós, Arnau Zheng, Yonggang Ruiz-Trillo, Iñaki Pan, Duojia European Research Council Generalitat de Catalunya Ministerio de Ciencia e Innovación (España) National Institutes of Health (US) Howard Hughes Medical Institute Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa. Through comparative analyses of recently sequenced holozoan genomes, we show that Hippo pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals. Remarkably, functional analysis of Hippo components of the amoeboid holozoan Capsaspora owczarzaki, performed in Drosophila melanogaster, demonstrate that the growth-regulatory activity of the Hippo pathway is conserved in this unicellular lineage. Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa. © 2012 The Authors. This work was supported by an Institució Catalana per a la Recerca i Estudis Avançats contract, a European Research Council Starting Grant (ERC-2007-StG-206883), a grant (BFU2008-02839/BMC) from Ministerio de Ciencia e Innovación (MICINN) to I. R.-T., and a National Institutes of Health grant (R01 EY015708) to D.P. A.S-P. was supported by a pregraduate Formacion Profesorado Universitario grant from MICINN. D.P. is an investigator of the Howard Hughes Medical Institute. Peer Reviewed 2015-05-21T07:44:21Z 2015-05-21T07:44:21Z 2012-01-26 2015-05-21T07:44:22Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.celrep.2011.11.004 issn: 2211-1247 Cell Reports 1(1): 13-20 (2012) http://hdl.handle.net/10261/115532 10.1016/j.celrep.2011.11.004 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/100000011 22832104 Publisher's version http://dx.doi.org/10.1016/j.celrep.2011.11.004 Sí open Elsevier |
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Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of the Hippo pathway in nonbilaterian animals, but failed to identify this pathway outside Metazoa. Through comparative analyses of recently sequenced holozoan genomes, we show that Hippo pathway components, such as the kinases Hippo and Warts, the coactivator Yorkie, and the transcription factor Scalloped, were already present in the unicellular ancestors of animals. Remarkably, functional analysis of Hippo components of the amoeboid holozoan Capsaspora owczarzaki, performed in Drosophila melanogaster, demonstrate that the growth-regulatory activity of the Hippo pathway is conserved in this unicellular lineage. Our findings show that the Hippo pathway evolved well before the origin of Metazoa and highlight the importance of Hippo signaling as a key developmental mechanism predating the origin of Metazoa. © 2012 The Authors. |
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European Research Council |
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European Research Council Sebé-Pedrós, Arnau Zheng, Yonggang Ruiz-Trillo, Iñaki Pan, Duojia |
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artículo |
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Sebé-Pedrós, Arnau Zheng, Yonggang Ruiz-Trillo, Iñaki Pan, Duojia |
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Sebé-Pedrós, Arnau Zheng, Yonggang Ruiz-Trillo, Iñaki Pan, Duojia Premetazoan Origin of the Hippo Signaling Pathway |
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Sebé-Pedrós, Arnau |
title |
Premetazoan Origin of the Hippo Signaling Pathway |
title_short |
Premetazoan Origin of the Hippo Signaling Pathway |
title_full |
Premetazoan Origin of the Hippo Signaling Pathway |
title_fullStr |
Premetazoan Origin of the Hippo Signaling Pathway |
title_full_unstemmed |
Premetazoan Origin of the Hippo Signaling Pathway |
title_sort |
premetazoan origin of the hippo signaling pathway |
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Elsevier |
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2012-01-26 |
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http://hdl.handle.net/10261/115532 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/100000002 http://dx.doi.org/10.13039/100000011 |
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1777668609531707392 |