Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release
Searching for effective strategies to modify the release rate of essential oil derivatives is one of the main challenges in designing prolonged-release antimicrobial food packaging materials. Herein, supercritical fluid technology and cocrystallization engineering were used to develop novel eugenol (EU) prolonged-release poly (lactic acid) (PLA) nanocomposite foams. Eugenol-phenazine (EU-PHE) cocrystals, produced by a solvent-free mechanochemical method, were incorporated by supercritical solvent impregnation (SSI) inside PLA nanocomposite foams with different contents of Cloisite30B® (C30B). The effect of the cocrystallization process and C30B content on the EU release kinetics and its relation with their antimicrobial activity by direct contact (anti-attachment) and release in broth culture were studied. The deposition of isolated spherical-shaped micrometric EU-PHE cocrystal particles with 0.8 µm average diameter inside the pores of PLA foams was evidenced by XRD, SEM, DSC, and TGA analyses. The release mechanism of EU and its cocrystal was defined as a quasi-Fickian diffusion process successfully described by the Korsmeyer-Peppas model with release rate constants up to 3.6-fold lower than the release rate constant of pure EU. The impregnated foam samples completely inhibited the attachment of Listeria monocytogenes and Salmonella Enteritidis and provided prolonged antimicrobial activity in broth culture against both food-borne pathogens. This study suggests a new, environmentally friendly method for designing prolonged-release antimicrobial food packaging materials.
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2023-12-30
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Subjects: | Antimicrobial packaging, C30B, Cocrystallization, Eugenol-phenazine cocrystal, Supercritical fluid technology, |
Online Access: | http://hdl.handle.net/10261/348604 http://dx.doi.org/10.13039/100007194 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004281 https://api.elsevier.com/content/abstract/scopus_id/85183390676 |
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dig-iata-es-10261-3486042024-05-14T20:52:57Z Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release Rojas, Adrián Misic, Dusan Zizovic, Irena López de Dicastillo, Carol Velásquez, Eliezer Rajewska, Aleksandra Rozas, Bastián Catalán, Luciano Vidal, Cristian Patiño Guarda, Abel Galotto, María José Agencia Nacional de Investigación y Desarrollo (Chile) Universidad de Santiago de Chile Agencia Estatal de Investigación (España) National Science Centre (Poland) 0000-0001-9253-1295 #NODATA# 0000-0003-3945-7051 #NODATA# #NODATA# 0009-0008-8537-463X #NODATA# #NODATA# #NODATA# #NODATA# #NODATA# Antimicrobial packaging C30B Cocrystallization Eugenol-phenazine cocrystal Supercritical fluid technology Searching for effective strategies to modify the release rate of essential oil derivatives is one of the main challenges in designing prolonged-release antimicrobial food packaging materials. Herein, supercritical fluid technology and cocrystallization engineering were used to develop novel eugenol (EU) prolonged-release poly (lactic acid) (PLA) nanocomposite foams. Eugenol-phenazine (EU-PHE) cocrystals, produced by a solvent-free mechanochemical method, were incorporated by supercritical solvent impregnation (SSI) inside PLA nanocomposite foams with different contents of Cloisite30B® (C30B). The effect of the cocrystallization process and C30B content on the EU release kinetics and its relation with their antimicrobial activity by direct contact (anti-attachment) and release in broth culture were studied. The deposition of isolated spherical-shaped micrometric EU-PHE cocrystal particles with 0.8 µm average diameter inside the pores of PLA foams was evidenced by XRD, SEM, DSC, and TGA analyses. The release mechanism of EU and its cocrystal was defined as a quasi-Fickian diffusion process successfully described by the Korsmeyer-Peppas model with release rate constants up to 3.6-fold lower than the release rate constant of pure EU. The impregnated foam samples completely inhibited the attachment of Listeria monocytogenes and Salmonella Enteritidis and provided prolonged antimicrobial activity in broth culture against both food-borne pathogens. This study suggests a new, environmentally friendly method for designing prolonged-release antimicrobial food packaging materials. M.J. Galotto and A. Rojas thank the support of Agencia Nacional de Investigación y Desarrollo through the Fondecyt regular Project N°1201301 and to the “Programa de Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia” (Project AFB220001). A. Rojas thanks the support of the University of Santiago de Chile through the Postdoctoral Fellowship DICYT Código 082371GL_Postdoc. C. López de Dicastillo acknowledges the “Ramon y Cajal” Fellowship RYC2020-029874-I/AEI/10.13039/501100011033 financed by the Spanish Ministry of Science and Innovation. D. Misic and I. Zizovic thank the support of Narodowe Centrum Nauki. (Poland), Grant number 2019/35/B/NZ9/02774. Peer reviewed 2024-02-28T09:28:17Z 2024-02-28T09:28:17Z 2023-12-30 artículo http://purl.org/coar/resource_type/c_6501 Chemical Engineering Journal 481: 148407 (2024) 1385-8947 http://hdl.handle.net/10261/348604 10.1016/j.cej.2023.148407 http://dx.doi.org/10.13039/100007194 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004281 2-s2.0-85183390676 https://api.elsevier.com/content/abstract/scopus_id/85183390676 en Chemical Engineering Journal Postprint https://doi.org/10.1016/j.cej.2023.148407 Sí open Elsevier |
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Antimicrobial packaging C30B Cocrystallization Eugenol-phenazine cocrystal Supercritical fluid technology Antimicrobial packaging C30B Cocrystallization Eugenol-phenazine cocrystal Supercritical fluid technology |
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Antimicrobial packaging C30B Cocrystallization Eugenol-phenazine cocrystal Supercritical fluid technology Antimicrobial packaging C30B Cocrystallization Eugenol-phenazine cocrystal Supercritical fluid technology Rojas, Adrián Misic, Dusan Zizovic, Irena López de Dicastillo, Carol Velásquez, Eliezer Rajewska, Aleksandra Rozas, Bastián Catalán, Luciano Vidal, Cristian Patiño Guarda, Abel Galotto, María José Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release |
description |
Searching for effective strategies to modify the release rate of essential oil derivatives is one of the main challenges in designing prolonged-release antimicrobial food packaging materials. Herein, supercritical fluid technology and cocrystallization engineering were used to develop novel eugenol (EU) prolonged-release poly (lactic acid) (PLA) nanocomposite foams. Eugenol-phenazine (EU-PHE) cocrystals, produced by a solvent-free mechanochemical method, were incorporated by supercritical solvent impregnation (SSI) inside PLA nanocomposite foams with different contents of Cloisite30B® (C30B). The effect of the cocrystallization process and C30B content on the EU release kinetics and its relation with their antimicrobial activity by direct contact (anti-attachment) and release in broth culture were studied. The deposition of isolated spherical-shaped micrometric EU-PHE cocrystal particles with 0.8 µm average diameter inside the pores of PLA foams was evidenced by XRD, SEM, DSC, and TGA analyses. The release mechanism of EU and its cocrystal was defined as a quasi-Fickian diffusion process successfully described by the Korsmeyer-Peppas model with release rate constants up to 3.6-fold lower than the release rate constant of pure EU. The impregnated foam samples completely inhibited the attachment of Listeria monocytogenes and Salmonella Enteritidis and provided prolonged antimicrobial activity in broth culture against both food-borne pathogens. This study suggests a new, environmentally friendly method for designing prolonged-release antimicrobial food packaging materials. |
author2 |
Agencia Nacional de Investigación y Desarrollo (Chile) |
author_facet |
Agencia Nacional de Investigación y Desarrollo (Chile) Rojas, Adrián Misic, Dusan Zizovic, Irena López de Dicastillo, Carol Velásquez, Eliezer Rajewska, Aleksandra Rozas, Bastián Catalán, Luciano Vidal, Cristian Patiño Guarda, Abel Galotto, María José |
format |
artículo |
topic_facet |
Antimicrobial packaging C30B Cocrystallization Eugenol-phenazine cocrystal Supercritical fluid technology |
author |
Rojas, Adrián Misic, Dusan Zizovic, Irena López de Dicastillo, Carol Velásquez, Eliezer Rajewska, Aleksandra Rozas, Bastián Catalán, Luciano Vidal, Cristian Patiño Guarda, Abel Galotto, María José |
author_sort |
Rojas, Adrián |
title |
Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release |
title_short |
Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release |
title_full |
Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release |
title_fullStr |
Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release |
title_full_unstemmed |
Supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging PLA nanocomposite foams loaded with eugenol cocrystals with prolonged release |
title_sort |
supercritical fluid and cocrystallization technologies for designing antimicrobial food packaging pla nanocomposite foams loaded with eugenol cocrystals with prolonged release |
publisher |
Elsevier |
publishDate |
2023-12-30 |
url |
http://hdl.handle.net/10261/348604 http://dx.doi.org/10.13039/100007194 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004281 https://api.elsevier.com/content/abstract/scopus_id/85183390676 |
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