Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads
Early life represents a critical window for metabolic, cognitive and immune system development, which is influenced by the maternal microbiome as well as the infant gut microbiome. Antibiotic exposure, mode of delivery and breastfeeding practices modulate the gut microbiome and the reservoir of antibiotic resistance genes (ARGs). Vertical and horizontal microbial gene transfer during early life and the mechanisms behind these transfers are being uncovered. In this review, we aim to provide an overview of the current knowledge on the transfer of antibiotic resistance in the mother-infant dyad through vertical and horizontal transmission and to highlight the main gaps and challenges in this area.
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Format: | artículo de revisión biblioteca |
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Elsevier
2024-01-17
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Subjects: | Antimicrobial resistance, Transmission, Immune system, Genes, |
Online Access: | http://hdl.handle.net/10261/346301 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100000781 https://api.elsevier.com/content/abstract/scopus_id/85182791140 |
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Antimicrobial resistance Transmission Immune system Genes Antimicrobial resistance Transmission Immune system Genes Bernabeu, Manuel Cabello Yeves, Elena Flores, Eduard Samarra, Anna Kimberley Summers, Joanna Marina, Alberto Collado, María Carmen Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads |
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Early life represents a critical window for metabolic, cognitive and immune system development, which is influenced by the maternal microbiome as well as the infant gut microbiome. Antibiotic exposure, mode of delivery and breastfeeding practices modulate the gut microbiome and the reservoir of antibiotic resistance genes (ARGs). Vertical and horizontal microbial gene transfer during early life and the mechanisms behind these transfers are being uncovered. In this review, we aim to provide an overview of the current knowledge on the transfer of antibiotic resistance in the mother-infant dyad through vertical and horizontal transmission and to highlight the main gaps and challenges in this area. |
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Generalitat Valenciana |
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Generalitat Valenciana Bernabeu, Manuel Cabello Yeves, Elena Flores, Eduard Samarra, Anna Kimberley Summers, Joanna Marina, Alberto Collado, María Carmen |
format |
artículo de revisión |
topic_facet |
Antimicrobial resistance Transmission Immune system Genes |
author |
Bernabeu, Manuel Cabello Yeves, Elena Flores, Eduard Samarra, Anna Kimberley Summers, Joanna Marina, Alberto Collado, María Carmen |
author_sort |
Bernabeu, Manuel |
title |
Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads |
title_short |
Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads |
title_full |
Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads |
title_fullStr |
Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads |
title_full_unstemmed |
Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads |
title_sort |
role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads |
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Elsevier |
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2024-01-17 |
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http://hdl.handle.net/10261/346301 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100000781 https://api.elsevier.com/content/abstract/scopus_id/85182791140 |
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dig-iata-es-10261-3463012024-05-16T20:45:37Z Role of vertical and horizontal microbial transmission of antimicrobial resistance genes in early life: insights from maternal-infant dyads Bernabeu, Manuel Cabello Yeves, Elena Flores, Eduard Samarra, Anna Kimberley Summers, Joanna Marina, Alberto Collado, María Carmen Generalitat Valenciana Ministerio de Ciencia, Innovación y Universidades (España) Agencia Estatal de Investigación (España) European Commission European Research Council #NODATA# #NODATA# #NODATA# #NODATA# #NODATA# #NODATA# 0000-0002-6204-4864 Antimicrobial resistance Transmission Immune system Genes Early life represents a critical window for metabolic, cognitive and immune system development, which is influenced by the maternal microbiome as well as the infant gut microbiome. Antibiotic exposure, mode of delivery and breastfeeding practices modulate the gut microbiome and the reservoir of antibiotic resistance genes (ARGs). Vertical and horizontal microbial gene transfer during early life and the mechanisms behind these transfers are being uncovered. In this review, we aim to provide an overview of the current knowledge on the transfer of antibiotic resistance in the mother-infant dyad through vertical and horizontal transmission and to highlight the main gaps and challenges in this area. This work has been supported by PROMETEO GVA (NEOHEALTH ref. 2020/012). The authors acknowledge the comments and suggestions of Dr. Raul Cabrera-Rubio. who thanks the Generalitat-Valenciana for the grant of the Plan GenT project (CDEIGENT 2020). M.B. thanks to the post-PhD grant 'Juan de la Cierva' (ref. JDC2022-050269-I) supported by the Spanish Ministry of Science, Innovation and Universities/State Investigation Agency (MCIU/AEI) and the European Union 'NextGenerationEU'/PRTR. E.C-Y received a FPI predoctoral fellowship from the Spanish Ministry of Science and Innovation with identifier PRE2020-092531. E.F.V thanks to a Predoctoral grant awarded by the Spanish Ministry of Science and Innovation and the European Social Fund Plus (ESF+) for the training of doctors within the framework of the State Plan for Scientific, Technical and Innovation Research 2021–2023 (ref. CEX2021-001189-S-20-1). A.S. acknowledges Generalitat-Valenciana-European Social Fund (ACIF/2021) for the predoctoral fellowship grant. M.C.C. acknowledges the support by the European Research Council Starting grant (MAMI grant ref. 639226), Horizon Europe Program (INITIALISE ref. 101094099), Spanish Ministry of Science and Innovation (MAMI-Plus ref. PID2022-139475OB-I00), by the Joint Action 'European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI-HDHL)' — FOOD-HYPERSENS call (ECOBIOTIC) and the national funding from Programación Conjunta Internacional (PCI) (ref. PCI2021-122059-2A), Spanish Government (Ministry of Science, Innovation and Universities) and also by Biostime Institute Nutrition & Care (BINC) grant. IATA-CSIC authors also acknowledge the Spanish government Ministry of Science and Innovation/State Investigation Agency (MCIN/AEI) to the Center of Excellence Accreditation Severo Ochoa (CEX2021-001189-S/MCIN/AEI/10.13039/501100011033). A.M. acknowledges the support by grants PID2019-108541GB-I00 and PID2022-137201NB-I00 from Spanish Government (Ministry of Science and Innovation). M.C.C. and A.M. are part of the CSIC's Global Health Platform (PTI Salud Global). Peer reviewed 2024-02-08T13:33:30Z 2024-02-08T13:33:30Z 2024-01-17 artículo de revisión http://purl.org/coar/resource_type/c_dcae04bc Current Opinion in Microbiology 77: 102424 (2024) 1369-5274 CEX2021-001189-S http://hdl.handle.net/10261/346301 10.1016/j.mib.2023.102424 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100000781 38237429 2-s2.0-85182791140 https://api.elsevier.com/content/abstract/scopus_id/85182791140 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/639226 info:eu-repo/grantAgreement/AEI//CEX 2021-001189-S info:eu-repo/grantAgreement/AEI//PID2022-139475OB-I00 info:eu-repo/grantAgreement/AEI//PCI2021-122059-2A info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108541GB-I00/ES/DECODIFICANDO LAS SEÑALIZACION Y COMUNICACION MICROBIANA/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-137201NB-I00/ES/REDES SOCIALES EN EL MUNDO MICROBIANO/ info:eu-repo/grantAgreement/EC/HE/101094099 Current opinion in microbiology Publisher's version https://doi.org/10.1016/j.mib.2023.102424 Sí open Elsevier |