Breast milk immune composition varies during the transition stage of lactation: characterization of immunotypes in the MAMI cohort

Breast milk is a complex and dynamic fluid needed for infant development and protection due to its content of bioactive factors such as immunoglobulins (Igs). Most studies focus primarily on IgA, but other types of Ig and even other immune components (cytokines and adipokines) may also play significant roles in neonatal health. As a first step, we aimed to characterize the Ig profile, many cytokines, and two adipokines (leptin and adiponectin) at two sampling time points within the transitional stage, which is the least studied phase in terms of these components. The secondary objective was to identify different breast milk immunotypes in the MAMI cohort substudy, and finally, we further aimed at analyzing maternal and infant characteristics to identify influencing factors of breast milk immune composition.

Bibliographic Details

Main Authors:	Rio-Aige, Karla, Fernández Bargalló, Aina, Vegas Lozano, Esteban, Miñarro Alonso, Antonio, Castell, Margarida, Selma Royo, Marta, Martínez Costa, Cecilia, Rodríguez Lagunas, María José, Collado, María Carmen, Pérez Cano, Francisco José
Other Authors:	Agencia Estatal de Investigación (España)
Format:	artículo biblioteca
Language:	English
Published:	Frontiers Media 2023-11-23
Subjects:	Adipokines, Breast milk, Breastfeeding, Cytokines, Immunoglobulins, Transitional stage,
Online Access:	http://hdl.handle.net/10261/341732 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008666 https://api.elsevier.com/content/abstract/scopus_id/85178911214
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