Impact of molecular weight and deacetylation degree of chitosan on the bioaccessibility of quercetin encapsulated in alginate/chitosan-coated zein nanoparticles

This work aimed at studying the effect of molecular weight (MW) and deacetylation degree (DD) of chitosan on the quercetin bioaccessibility encapsulated in alginate/chitosan-coated zein nanoparticles (alg/chiZN). The chitosan coating layer produced nanoparticulate systems with good stability parameters, high encapsulation efficiency (EE) and a higher bioaccessibilty of quercetin after in-vitro digestion. By increasing the DD of chitosan, the ζ-potential of the colloidal system significantly increased (≥27.1 mV), while low and very low MW chitosans generated systems with smaller particle sizes (≤ 277.8 nm) and polydispersity index [PDI (0.189)]. The best results, in terms of EE (≥84.44) and bioaccessibility (≥76.70), were obtained when the systems were prepared with low MW chitosan and high DD. Thus, the alg/chiZN nanocapsules may be a promising delivery system for improving the quercetin bioaccessibility or other compounds with a similar chemical nature, especially when higher DD and lower MWs are used.

Bibliographic Details

Main Authors:	Carrasco-Sandoval, Jonathan, Aranda, Mario, Henríquez-Aedo, Karem, Fernández, Marcos, López-Rubio, Amparo, Fabra, María José
Other Authors:	Fondo Nacional de Desarrollo Científico y Tecnológico (Chile)
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2023-05-13
Subjects:	Chitosan, Deacetylation degree, Molecular weight, Nanoparticles, Quercetin,
Online Access:	http://hdl.handle.net/10261/309702 http://dx.doi.org/10.13039/501100002850 https://api.elsevier.com/content/abstract/scopus_id/85159183704
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