Bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin
The present invention relates to bioconjugates and labeled derivatives of the adducts formed by the reaction of patulin with benzene-1,2-dithiols or their salts. Said conjugates are suitable for the production of antibodies capable of recognizing the aforementioned patulin-(benzene-1,2-dithiols) adducts with high affinity and specificity. Likewise, the present invention also relates to the use of bioconjugates of patulin-(benzene-1,2-dithiols) adducts and of labeled derivatives thereof as assay antigens. Furthermore, the present invention also relates to immunochemical methods for the analysis of patulin, using the bioconjugates and labeled derivatives and antibodies of the invention, which include a previous step to quantitatively convert patulin into these adducts. This invention also provides a kit for analyzing patulin comprising a benzene-1,2-dithiol or its salts, antibodies against patulin-(benzene-1,2-dithiols) adducts, and assay antigens.
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | solicitud de patente biblioteca |
| Language: | English |
| Published: |
2022-12-28
|
| Online Access: | http://hdl.handle.net/10261/286539 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
dig-iata-es-10261-286539 |
|---|---|
| record_format |
koha |
| spelling |
dig-iata-es-10261-2865392023-01-11T11:04:20Z Bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin Biokonjugate und antikörper für die immunodetektion mithilfe der derivatisierung des mykotoxins patulin Bioconjugués et anticorps pour l'immunodétection assistée par dérivation de la mycotoxine patuline Abad Fuentes, Antonio Mercader Badia, Josep Vicent Duncan, Hadyn Abad Somovilla, Antonio Agulló, Consuelo The present invention relates to bioconjugates and labeled derivatives of the adducts formed by the reaction of patulin with benzene-1,2-dithiols or their salts. Said conjugates are suitable for the production of antibodies capable of recognizing the aforementioned patulin-(benzene-1,2-dithiols) adducts with high affinity and specificity. Likewise, the present invention also relates to the use of bioconjugates of patulin-(benzene-1,2-dithiols) adducts and of labeled derivatives thereof as assay antigens. Furthermore, the present invention also relates to immunochemical methods for the analysis of patulin, using the bioconjugates and labeled derivatives and antibodies of the invention, which include a previous step to quantitatively convert patulin into these adducts. This invention also provides a kit for analyzing patulin comprising a benzene-1,2-dithiol or its salts, antibodies against patulin-(benzene-1,2-dithiols) adducts, and assay antigens. No Consejo Superior de Investigaciones Científicas (CSIC), Universitat de València A1 Solicitud de patente con informe sobre el estado de la técnica 2023-01-11T11:01:30Z 2023-01-11T11:01:30Z 2022-12-28 2021-02-17 solicitud de patente EP4109099 A1 http://hdl.handle.net/10261/286539 21718625 en ES2849398 A1 (2021-08-17) ES2849398 B2 (2022-04-06) WO2021165557 A1 (2021-08-26) Sí open application/pdf |
| institution |
IATA ES |
| collection |
DSpace |
| country |
España |
| countrycode |
ES |
| component |
Bibliográfico |
| access |
En linea |
| databasecode |
dig-iata-es |
| tag |
biblioteca |
| region |
Europa del Sur |
| libraryname |
Biblioteca del IATA España |
| language |
English |
| description |
The present invention relates to bioconjugates and labeled derivatives of the adducts formed by the reaction of patulin with benzene-1,2-dithiols or their salts. Said conjugates are suitable for the production of antibodies capable of recognizing the aforementioned patulin-(benzene-1,2-dithiols) adducts with high affinity and specificity. Likewise, the present invention also relates to the use of bioconjugates of patulin-(benzene-1,2-dithiols) adducts and of labeled derivatives thereof as assay antigens. Furthermore, the present invention also relates to immunochemical methods for the analysis of patulin, using the bioconjugates and labeled derivatives and antibodies of the invention, which include a previous step to quantitatively convert patulin into these adducts. This invention also provides a kit for analyzing patulin comprising a benzene-1,2-dithiol or its salts, antibodies against patulin-(benzene-1,2-dithiols) adducts, and assay antigens. |
| format |
solicitud de patente |
| author |
Abad Fuentes, Antonio Mercader Badia, Josep Vicent Duncan, Hadyn Abad Somovilla, Antonio Agulló, Consuelo |
| spellingShingle |
Abad Fuentes, Antonio Mercader Badia, Josep Vicent Duncan, Hadyn Abad Somovilla, Antonio Agulló, Consuelo Bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin |
| author_facet |
Abad Fuentes, Antonio Mercader Badia, Josep Vicent Duncan, Hadyn Abad Somovilla, Antonio Agulló, Consuelo |
| author_sort |
Abad Fuentes, Antonio |
| title |
Bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin |
| title_short |
Bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin |
| title_full |
Bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin |
| title_fullStr |
Bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin |
| title_full_unstemmed |
Bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin |
| title_sort |
bioconjugates and antibodies for immunodetection assisted by derivatization of the mycotoxin patulin |
| publishDate |
2022-12-28 |
| url |
http://hdl.handle.net/10261/286539 |
| work_keys_str_mv |
AT abadfuentesantonio bioconjugatesandantibodiesforimmunodetectionassistedbyderivatizationofthemycotoxinpatulin AT mercaderbadiajosepvicent bioconjugatesandantibodiesforimmunodetectionassistedbyderivatizationofthemycotoxinpatulin AT duncanhadyn bioconjugatesandantibodiesforimmunodetectionassistedbyderivatizationofthemycotoxinpatulin AT abadsomovillaantonio bioconjugatesandantibodiesforimmunodetectionassistedbyderivatizationofthemycotoxinpatulin AT agulloconsuelo bioconjugatesandantibodiesforimmunodetectionassistedbyderivatizationofthemycotoxinpatulin AT abadfuentesantonio biokonjugateundantikorperfurdieimmunodetektionmithilfederderivatisierungdesmykotoxinspatulin AT mercaderbadiajosepvicent biokonjugateundantikorperfurdieimmunodetektionmithilfederderivatisierungdesmykotoxinspatulin AT duncanhadyn biokonjugateundantikorperfurdieimmunodetektionmithilfederderivatisierungdesmykotoxinspatulin AT abadsomovillaantonio biokonjugateundantikorperfurdieimmunodetektionmithilfederderivatisierungdesmykotoxinspatulin AT agulloconsuelo biokonjugateundantikorperfurdieimmunodetektionmithilfederderivatisierungdesmykotoxinspatulin AT abadfuentesantonio bioconjuguesetanticorpspourlimmunodetectionassisteeparderivationdelamycotoxinepatuline AT mercaderbadiajosepvicent bioconjuguesetanticorpspourlimmunodetectionassisteeparderivationdelamycotoxinepatuline AT duncanhadyn bioconjuguesetanticorpspourlimmunodetectionassisteeparderivationdelamycotoxinepatuline AT abadsomovillaantonio bioconjuguesetanticorpspourlimmunodetectionassisteeparderivationdelamycotoxinepatuline AT agulloconsuelo bioconjuguesetanticorpspourlimmunodetectionassisteeparderivationdelamycotoxinepatuline |
| _version_ |
1777670248438169600 |