Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome
Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. Methods: We compared the effect of fecal microbiota transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral butyrate supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin transporter (SERT) binding as well as stable isotope-determined insulin sensitivity at baseline and after 4 weeks in 24 male and female treatment-naïve metabolic syndrome subjects. Plasma metabolites and fecal microbiota were also determined at these time points. Results: We observed an increase in brain DAT after donor FMT compared to oral butyrate that reduced this binding. However, no effect on body weight and insulin sensitivity was demonstrated after post-RYGB donor feces transfer in humans with metabolic syndrome. Increases in fecal levels of Bacteroides uniformis were significantly associated with an increase in DAT, whereas increases in Prevotella spp. showed an inverse association. Changes in the plasma metabolites glycine, betaine, methionine, and lysine (associated with the S-adenosylmethionine cycle) were also associated with altered striatal DAT expression. Conclusions: Although more and larger studies are needed, our data suggest a potential gut microbiota-driven modulation of brain dopamine and serotonin transporters in human subjects with obese metabolic syndrome. These data also suggest the presence of a gut-brain axis in humans that can be modulated.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Other Authors: | |
Format: | artículo biblioteca |
Language: | English |
Published: |
Elsevier
2020-09-08
|
Subjects: | Obesity, Gut microbiota, Gut-brain axis, Metabolites, |
Online Access: | http://hdl.handle.net/10261/246782 http://dx.doi.org/10.13039/501100000780 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-iata-es-10261-246782 |
---|---|
record_format |
koha |
spelling |
dig-iata-es-10261-2467822021-12-27T16:03:09Z Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome Hartstra, Annick V. Schüppel, Valentina Imangaliyev, Sultan Schrantee, Anouk Prodan, Andrei Collard, Didier Levin, Evgeni Dallinga-Thie, Geesje Ackermans, Mariette T. Winkelmeijer, Maaike Havik, Stefan R. Metwaly, Amira Lagkouvardos, Ilias Nier, Anika Bergheim, Ina Heikenwalder, Mathias Dunkel, Andreas Nederveen, Aart J. Liebisch, Gerhard Mancano, Giulia Claus, Sandrine P. Benítez-Páez, Alfonso la Fleur, Susanne E. Bergman, Jacques J. Gerdes, Victor Sanz Herranz, Yolanda Booij, Jan Kemper, Elles Groen, Albert K. Serlie, Mireille J. Haller, Dirk Nieuwdorp, Max European Commission Obesity Gut microbiota Gut-brain axis Metabolites Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. Methods: We compared the effect of fecal microbiota transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral butyrate supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin transporter (SERT) binding as well as stable isotope-determined insulin sensitivity at baseline and after 4 weeks in 24 male and female treatment-naïve metabolic syndrome subjects. Plasma metabolites and fecal microbiota were also determined at these time points. Results: We observed an increase in brain DAT after donor FMT compared to oral butyrate that reduced this binding. However, no effect on body weight and insulin sensitivity was demonstrated after post-RYGB donor feces transfer in humans with metabolic syndrome. Increases in fecal levels of Bacteroides uniformis were significantly associated with an increase in DAT, whereas increases in Prevotella spp. showed an inverse association. Changes in the plasma metabolites glycine, betaine, methionine, and lysine (associated with the S-adenosylmethionine cycle) were also associated with altered striatal DAT expression. Conclusions: Although more and larger studies are needed, our data suggest a potential gut microbiota-driven modulation of brain dopamine and serotonin transporters in human subjects with obese metabolic syndrome. These data also suggest the presence of a gut-brain axis in humans that can be modulated. This study was funded by FP7-EU consortium MyNewGut grant agreement no. 613979 (to which A.V.H. was appointed). M. Nieuwdorp is supported by a ZONMW-VIDI grant 2013 (016.146.327). Peer reviewed 2021-07-29T05:59:45Z 2021-07-29T05:59:45Z 2020-09-08 artículo http://purl.org/coar/resource_type/c_6501 Molecular Metabolism 42: 101076 (2020) 2212-8778 http://hdl.handle.net/10261/246782 10.1016/j.molmet.2020.101076 http://dx.doi.org/10.13039/501100000780 32916306 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/FP7/613979 Publisher's version https://doi.org/10.1016/j.molmet.2020.101076 Sí open Elsevier |
institution |
IATA ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-iata-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del IATA España |
language |
English |
topic |
Obesity Gut microbiota Gut-brain axis Metabolites Obesity Gut microbiota Gut-brain axis Metabolites |
spellingShingle |
Obesity Gut microbiota Gut-brain axis Metabolites Obesity Gut microbiota Gut-brain axis Metabolites Hartstra, Annick V. Schüppel, Valentina Imangaliyev, Sultan Schrantee, Anouk Prodan, Andrei Collard, Didier Levin, Evgeni Dallinga-Thie, Geesje Ackermans, Mariette T. Winkelmeijer, Maaike Havik, Stefan R. Metwaly, Amira Lagkouvardos, Ilias Nier, Anika Bergheim, Ina Heikenwalder, Mathias Dunkel, Andreas Nederveen, Aart J. Liebisch, Gerhard Mancano, Giulia Claus, Sandrine P. Benítez-Páez, Alfonso la Fleur, Susanne E. Bergman, Jacques J. Gerdes, Victor Sanz Herranz, Yolanda Booij, Jan Kemper, Elles Groen, Albert K. Serlie, Mireille J. Haller, Dirk Nieuwdorp, Max Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome |
description |
Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown.
Methods: We compared the effect of fecal microbiota transfer (FMT) from post-Roux-en-Y gastric bypass (RYGB) donors vs oral butyrate supplementation on (123I-FP-CIT-determined) brain dopamine transporter (DAT) and serotonin transporter (SERT) binding as well as stable isotope-determined insulin sensitivity at baseline and after 4 weeks in 24 male and female treatment-naïve metabolic syndrome subjects. Plasma metabolites and fecal microbiota were also determined at these time points.
Results: We observed an increase in brain DAT after donor FMT compared to oral butyrate that reduced this binding. However, no effect on body weight and insulin sensitivity was demonstrated after post-RYGB donor feces transfer in humans with metabolic syndrome. Increases in fecal levels of Bacteroides uniformis were significantly associated with an increase in DAT, whereas increases in Prevotella spp. showed an inverse association. Changes in the plasma metabolites glycine, betaine, methionine, and lysine (associated with the S-adenosylmethionine cycle) were also associated with altered striatal DAT expression.
Conclusions: Although more and larger studies are needed, our data suggest a potential gut microbiota-driven modulation of brain dopamine and serotonin transporters in human subjects with obese metabolic syndrome. These data also suggest the presence of a gut-brain axis in humans that can be modulated. |
author2 |
European Commission |
author_facet |
European Commission Hartstra, Annick V. Schüppel, Valentina Imangaliyev, Sultan Schrantee, Anouk Prodan, Andrei Collard, Didier Levin, Evgeni Dallinga-Thie, Geesje Ackermans, Mariette T. Winkelmeijer, Maaike Havik, Stefan R. Metwaly, Amira Lagkouvardos, Ilias Nier, Anika Bergheim, Ina Heikenwalder, Mathias Dunkel, Andreas Nederveen, Aart J. Liebisch, Gerhard Mancano, Giulia Claus, Sandrine P. Benítez-Páez, Alfonso la Fleur, Susanne E. Bergman, Jacques J. Gerdes, Victor Sanz Herranz, Yolanda Booij, Jan Kemper, Elles Groen, Albert K. Serlie, Mireille J. Haller, Dirk Nieuwdorp, Max |
format |
artículo |
topic_facet |
Obesity Gut microbiota Gut-brain axis Metabolites |
author |
Hartstra, Annick V. Schüppel, Valentina Imangaliyev, Sultan Schrantee, Anouk Prodan, Andrei Collard, Didier Levin, Evgeni Dallinga-Thie, Geesje Ackermans, Mariette T. Winkelmeijer, Maaike Havik, Stefan R. Metwaly, Amira Lagkouvardos, Ilias Nier, Anika Bergheim, Ina Heikenwalder, Mathias Dunkel, Andreas Nederveen, Aart J. Liebisch, Gerhard Mancano, Giulia Claus, Sandrine P. Benítez-Páez, Alfonso la Fleur, Susanne E. Bergman, Jacques J. Gerdes, Victor Sanz Herranz, Yolanda Booij, Jan Kemper, Elles Groen, Albert K. Serlie, Mireille J. Haller, Dirk Nieuwdorp, Max |
author_sort |
Hartstra, Annick V. |
title |
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome |
title_short |
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome |
title_full |
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome |
title_fullStr |
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome |
title_full_unstemmed |
Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome |
title_sort |
infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome |
publisher |
Elsevier |
publishDate |
2020-09-08 |
url |
http://hdl.handle.net/10261/246782 http://dx.doi.org/10.13039/501100000780 |
work_keys_str_mv |
AT hartstraannickv infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT schuppelvalentina infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT imangaliyevsultan infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT schranteeanouk infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT prodanandrei infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT collarddidier infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT levinevgeni infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT dallingathiegeesje infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT ackermansmariettet infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT winkelmeijermaaike infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT havikstefanr infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT metwalyamira infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT lagkouvardosilias infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT nieranika infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT bergheimina infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT heikenwaldermathias infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT dunkelandreas infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT nederveenaartj infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT liebischgerhard infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT mancanogiulia infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT claussandrinep infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT benitezpaezalfonso infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT lafleursusannee infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT bergmanjacquesj infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT gerdesvictor infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT sanzherranzyolanda infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT booijjan infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT kemperelles infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT groenalbertk infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT serliemireillej infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT hallerdirk infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome AT nieuwdorpmax infusionofdonorfecesaffectsthegutbrainaxisinhumanswithmetabolicsyndrome |
_version_ |
1777670189043679232 |