The Breast Milk Immunoglobulinome
Breast milk components contribute to the infant’s immune development and protection, and among other immune factors, immunoglobulins (Igs) are the most studied. The presence of IgA in milk has been known for a long time; however, less information is available about the presence of other Igs such as IgM, IgG, and their subtypes (IgG1, IgG2, IgG3, and IgG4) or even IgE or IgD. The total Ig concentration and profile will change during the course of lactation; however, there is a great variability among studies due to several variables that limit establishing a clear pattern. In this context, the aim of this review was firstly to shed light on the Ig concentration in breast milk based on scientific evidence and secondly to study the main factors contributing to such variability. A search strategy provided only 75 studies with the prespecified eligibility criteria. The concentrations and proportions found have been established based on the intrinsic factors of the study—such as the sampling time and quantification technique—as well as participant-dependent factors, such as lifestyle and environment. All these factors contribute to the variability of the immunoglobulinome described in the literature and should be carefully addressed for further well-designed studies and data interpretation.
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Format: | artículo de revisión biblioteca |
Language: | English |
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Multidisciplinary Digital Publishing Institute
2021-05-26
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Subjects: | Immunoglobulin, IgA, Breast milk, Immunoglobulinome, |
Online Access: | http://hdl.handle.net/10261/244273 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008666 |
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dig-iata-es-10261-2442732021-12-28T16:53:20Z The Breast Milk Immunoglobulinome Rio-Aige, Karla Azagra-Boronat, Ignasi Castell, Margarida Selma Royo, Marta Collado, María Carmen Rodríguez-Lagunas, María J. Pérez-Cano, Francisco J. Fundació La Marató de TV3 Ministerio de Ciencia, Innovación y Universidades (España) European Commission Immunoglobulin IgA Breast milk Immunoglobulinome Breast milk components contribute to the infant’s immune development and protection, and among other immune factors, immunoglobulins (Igs) are the most studied. The presence of IgA in milk has been known for a long time; however, less information is available about the presence of other Igs such as IgM, IgG, and their subtypes (IgG1, IgG2, IgG3, and IgG4) or even IgE or IgD. The total Ig concentration and profile will change during the course of lactation; however, there is a great variability among studies due to several variables that limit establishing a clear pattern. In this context, the aim of this review was firstly to shed light on the Ig concentration in breast milk based on scientific evidence and secondly to study the main factors contributing to such variability. A search strategy provided only 75 studies with the prespecified eligibility criteria. The concentrations and proportions found have been established based on the intrinsic factors of the study—such as the sampling time and quantification technique—as well as participant-dependent factors, such as lifestyle and environment. All these factors contribute to the variability of the immunoglobulinome described in the literature and should be carefully addressed for further well-designed studies and data interpretation. This work was supported by the research grant from LaMarató-TV3 (DIM-2-ELI, ref. 2018-27/30-31). M.C.C. also acknowledges the grant RTI2018-097982-B-I00 from Spanish Ministry of Science and Universities (MCIU) and the grant from the European Research Council (ERC Starting Grant H2020, project no. 639226). K.R.-A. holds a fellowship from the Spanish Ministry of Economy, Industry, and Competitiveness (FPU19/05150). Peer reviewed 2021-06-22T06:36:28Z 2021-06-22T06:36:28Z 2021-05-26 artículo de revisión http://purl.org/coar/resource_type/c_dcae04bc Nutrients 13(6):1810 (2021) http://hdl.handle.net/10261/244273 10.3390/nu13061810 2072-6643 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008666 34073540 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/639226 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097982-B-I00 Publisher's version https://doi.org/10.3390/nu13061810 Sí open Multidisciplinary Digital Publishing Institute |
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Immunoglobulin IgA Breast milk Immunoglobulinome Immunoglobulin IgA Breast milk Immunoglobulinome |
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Immunoglobulin IgA Breast milk Immunoglobulinome Immunoglobulin IgA Breast milk Immunoglobulinome Rio-Aige, Karla Azagra-Boronat, Ignasi Castell, Margarida Selma Royo, Marta Collado, María Carmen Rodríguez-Lagunas, María J. Pérez-Cano, Francisco J. The Breast Milk Immunoglobulinome |
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Breast milk components contribute to the infant’s immune development and protection, and among other immune factors, immunoglobulins (Igs) are the most studied. The presence of IgA in milk has been known for a long time; however, less information is available about the presence of other Igs such as IgM, IgG, and their subtypes (IgG1, IgG2, IgG3, and IgG4) or even IgE or IgD. The total Ig concentration and profile will change during the course of lactation; however, there is a great variability among studies due to several variables that limit establishing a clear pattern. In this context, the aim of this review was firstly to shed light on the Ig concentration in breast milk based on scientific evidence and secondly to study the main factors contributing to such variability. A search strategy provided only 75 studies with the prespecified eligibility criteria. The concentrations and proportions found have been established based on the intrinsic factors of the study—such as the sampling time and quantification technique—as well as participant-dependent factors, such as lifestyle and environment. All these factors contribute to the variability of the immunoglobulinome described in the literature and should be carefully addressed for further well-designed studies and data interpretation. |
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Fundació La Marató de TV3 |
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Fundació La Marató de TV3 Rio-Aige, Karla Azagra-Boronat, Ignasi Castell, Margarida Selma Royo, Marta Collado, María Carmen Rodríguez-Lagunas, María J. Pérez-Cano, Francisco J. |
format |
artículo de revisión |
topic_facet |
Immunoglobulin IgA Breast milk Immunoglobulinome |
author |
Rio-Aige, Karla Azagra-Boronat, Ignasi Castell, Margarida Selma Royo, Marta Collado, María Carmen Rodríguez-Lagunas, María J. Pérez-Cano, Francisco J. |
author_sort |
Rio-Aige, Karla |
title |
The Breast Milk Immunoglobulinome |
title_short |
The Breast Milk Immunoglobulinome |
title_full |
The Breast Milk Immunoglobulinome |
title_fullStr |
The Breast Milk Immunoglobulinome |
title_full_unstemmed |
The Breast Milk Immunoglobulinome |
title_sort |
breast milk immunoglobulinome |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021-05-26 |
url |
http://hdl.handle.net/10261/244273 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008666 |
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