Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota

Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota

Read-only version at https://rdcu.be/chxsS.-- The final publication is available at http://link.springer.com

Saved in:
Bibliographic Details
Main Authors: Selma Royo, Marta, García Mantrana, Izaskun, Calatayud, Marta, Parra Llorca, A., Martínez Costa, C., Collado, María Carmen
Other Authors: European Commission
Format: artículo biblioteca
Language:English
Published: Springer Nature 2020-07-29
Subjects:Maternal diet, Intestinal permeability, Microbiota,
Online Access:http://hdl.handle.net/10261/218764
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003359
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-iata-es-10261-218764
record_format koha
spelling dig-iata-es-10261-2187642021-07-29T04:32:42Z Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota Selma Royo, Marta García Mantrana, Izaskun Calatayud, Marta Parra Llorca, A. Martínez Costa, C. Collado, María Carmen European Commission Generalitat Valenciana Maternal diet Intestinal permeability Microbiota Read-only version at https://rdcu.be/chxsS.-- The final publication is available at http://link.springer.com Background: Diet has an important role in host–microbiome interplay, which may result in intestinal permeability changes and physiopathological effects at a systemic level. Despite the importance of maternal microbiota as the main contributor to the initial microbial seeding, little is known about the effects of maternal diet during pregnancy on maternal-neonatal microbiota. Objectives: This study aimed at ascertaining the possible associations between maternal dietary intake during pregnancy and neonatal microbiota at birth and to evaluate the relationship with maternal intestinal markers. Methods: In a nested cross-sectional study in the longitudinal MAMI cohort, maternal-neonatal microbiota profiling at birth (n = 73) was assessed by 16S rRNA gene sequencing. Maternal intestinal markers as zonulin, intestinal alkaline phosphatase (IAP) activity and faecal calprotectin were measured in faeces. Furthermore, maternal-neonatal clinical and anthropometric data, as well as maternal nutrient intake during pregnancy obtained by FFQ questionnaires, were collected. Results: Maternal diet is associated with both maternal and neonatal microbiota at the time of birth, in a delivery mode-dependent manner. The existing link between maternal diet, intestinal makers and neonatal gut microbiota would be mainly influenced by the intake of saturated (SFA) and monounsaturated fatty acids (MUFA). Members of Firmicutes in the neonatal microbiota were positively associated with maternal fat intake, especially SFA and MUFA, and negatively correlated to fibre, proteins from vegetable sources and vitamins. Conclusions: Maternal diet during pregnancy, mainly fat intake (SFA and MUFA), was related to intestinal markers, thus likely shifting the microbial transmission to the neonate and priming the neonatal microbial profile with potential health outcomes. Clinical trial registry: NCT03552939 The study was financially supported by European Research Council under the European Union's Horizon 2020 research and innovation program (ERC starting grant, n° 639226). M.S-R. is supported by a Predoctoral Fellowship from Generalitat Valenciana-European Social Fund (ASCII2016). Peer reviewed 2020-08-28T05:53:54Z 2020-08-28T05:53:54Z 2020-07-29 artículo http://purl.org/coar/resource_type/c_6501 European Journal of Nutrition 60:1429-1442 (2021) 1436-6207 http://hdl.handle.net/10261/218764 10.1007/s00394-020-02337-7 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/639226 Postprint https://doi.org/10.1007/s00394-020-02337-7 Sí open Springer Nature
institution IATA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-iata-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IATA España
language English
topic Maternal diet
Intestinal permeability
Microbiota
Maternal diet
Intestinal permeability
Microbiota
spellingShingle Maternal diet
Intestinal permeability
Microbiota
Maternal diet
Intestinal permeability
Microbiota
Selma Royo, Marta
García Mantrana, Izaskun
Calatayud, Marta
Parra Llorca, A.
Martínez Costa, C.
Collado, María Carmen
Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
description Read-only version at https://rdcu.be/chxsS.-- The final publication is available at http://link.springer.com
author2 European Commission
author_facet European Commission
Selma Royo, Marta
García Mantrana, Izaskun
Calatayud, Marta
Parra Llorca, A.
Martínez Costa, C.
Collado, María Carmen
format artículo
topic_facet Maternal diet
Intestinal permeability
Microbiota
author Selma Royo, Marta
García Mantrana, Izaskun
Calatayud, Marta
Parra Llorca, A.
Martínez Costa, C.
Collado, María Carmen
author_sort Selma Royo, Marta
title Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_short Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_full Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_fullStr Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_full_unstemmed Maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
title_sort maternal diet during pregnancy and intestinal markers are associated with early gut microbiota
publisher Springer Nature
publishDate 2020-07-29
url http://hdl.handle.net/10261/218764
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100003359
work_keys_str_mv AT selmaroyomarta maternaldietduringpregnancyandintestinalmarkersareassociatedwithearlygutmicrobiota
AT garciamantranaizaskun maternaldietduringpregnancyandintestinalmarkersareassociatedwithearlygutmicrobiota
AT calatayudmarta maternaldietduringpregnancyandintestinalmarkersareassociatedwithearlygutmicrobiota
AT parrallorcaa maternaldietduringpregnancyandintestinalmarkersareassociatedwithearlygutmicrobiota
AT martinezcostac maternaldietduringpregnancyandintestinalmarkersareassociatedwithearlygutmicrobiota
AT colladomariacarmen maternaldietduringpregnancyandintestinalmarkersareassociatedwithearlygutmicrobiota
_version_ 1777670142064328704

Similar Items