Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies
This is the Author’s Original Manuscript of an article published by Taylor & Francis in Expert Review of Proteomics on 18 Sep 2019, available online: http://www.tandfonline.com/10.1080/14789450.2019.1664292
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Other Authors: | |
| Format: | artículo de revisión biblioteca |
| Language: | English |
| Published: |
Taylor & Francis
2019-09-18
|
| Subjects: | Cancer, ICP-MS, Metallomics, Microbiota, Neurodegenerative diseases, Selenium, Selenoproteins, Speciation, |
| Online Access: | http://hdl.handle.net/10261/204184 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008054 http://dx.doi.org/10.13039/501100011011 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
dig-iata-es-10261-204184 |
|---|---|
| record_format |
koha |
| spelling |
dig-iata-es-10261-2041842021-12-28T11:31:36Z Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies Arias Borrego, Ana Callejón Leblic, Belén Calatayud, Marta Gómez-Ariza, José Luis Collado, María Carmen García Barrera, Tamara Ministerio de Ciencia, Innovación y Universidades (España) Junta de Andalucía Fundación Ramón Areces European Commission Cancer ICP-MS Metallomics Microbiota Neurodegenerative diseases Selenium Selenoproteins Speciation This is the Author’s Original Manuscript of an article published by Taylor & Francis in Expert Review of Proteomics on 18 Sep 2019, available online: http://www.tandfonline.com/10.1080/14789450.2019.1664292 Introduction: Selenium plays many key roles in health especially in connection with cancer and neurodegenerative diseases. However, it needs to be appreciated that the essentiality/toxicity of selenium depends on both, a narrow range of concentration and the chemical specie involved. In this context, selenoproteins are essential biomolecules against these disorders, mainly due to its antioxidant action. To this end, analytical methodologies may allow identifying and quantifying individual selenospecies in human biofluids and tissues. Areas covered: This review focus on the role of selenoproteins in medicine, with special emphasis in cancer and neurodegenerative diseases, considering the possible link with gut microbiota. In particular, this article reviews the analytical techniques and procedures recently developed for the absolute quantification of selenoproteins and selenometabolites in human biofluids and tissues. Expert commentary: The beneficial role of selenium in human health has been extensively studied and reviewed. However, several challenges remain unsolved as discussed in this article: (i) speciation of selenium (especially selenoproteins) in cancer and neurodegenerative disease patients; (ii) supplementation of selenium in humans using functional foods and nutraceuticals; (iii) the link between selenium and selenoproteins expression and the gut microbiota and (iv) analytical methods and pitfalls for the absolute quantification of selenoproteins and selenometabolites. This work was supported by the project PG2018-096608-B-C21 from the Spanish Ministry of Science, Innovation and Universities (MINECO), Project UHU-1256905 from the Regional Ministry of Economy, Knowledge, Business and University (Andalusian Government, Spain) and Project from The Ramón Areces Foundation. Finally, authors are grateful to FEDER (European Community) for financial support, Grant UNHU13-1E-1611. Peer reviewed 2020-03-17T11:52:28Z 2020-03-17T11:52:28Z 2019-09-18 artículo de revisión http://purl.org/coar/resource_type/c_dcae04bc Expert Review of Proteomics 16 (10): 805-814 (2019) 1478-9450 http://hdl.handle.net/10261/204184 10.1080/14789450.2019.1664292 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008054 http://dx.doi.org/10.13039/501100011011 en #PLACEHOLDER_PARENT_METADATA_VALUE# MICIU/ICTI2017-2020/PGC2018-096608-B-C21 Postprint https://doi.org/10.1080/14789450.2019.1664292 Sí open Taylor & Francis |
| institution |
IATA ES |
| collection |
DSpace |
| country |
España |
| countrycode |
ES |
| component |
Bibliográfico |
| access |
En linea |
| databasecode |
dig-iata-es |
| tag |
biblioteca |
| region |
Europa del Sur |
| libraryname |
Biblioteca del IATA España |
| language |
English |
| topic |
Cancer ICP-MS Metallomics Microbiota Neurodegenerative diseases Selenium Selenoproteins Speciation Cancer ICP-MS Metallomics Microbiota Neurodegenerative diseases Selenium Selenoproteins Speciation |
| spellingShingle |
Cancer ICP-MS Metallomics Microbiota Neurodegenerative diseases Selenium Selenoproteins Speciation Cancer ICP-MS Metallomics Microbiota Neurodegenerative diseases Selenium Selenoproteins Speciation Arias Borrego, Ana Callejón Leblic, Belén Calatayud, Marta Gómez-Ariza, José Luis Collado, María Carmen García Barrera, Tamara Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies |
| description |
This is the Author’s Original Manuscript of an article published by Taylor & Francis in Expert Review of Proteomics on 18 Sep 2019, available online: http://www.tandfonline.com/10.1080/14789450.2019.1664292 |
| author2 |
Ministerio de Ciencia, Innovación y Universidades (España) |
| author_facet |
Ministerio de Ciencia, Innovación y Universidades (España) Arias Borrego, Ana Callejón Leblic, Belén Calatayud, Marta Gómez-Ariza, José Luis Collado, María Carmen García Barrera, Tamara |
| format |
artículo de revisión |
| topic_facet |
Cancer ICP-MS Metallomics Microbiota Neurodegenerative diseases Selenium Selenoproteins Speciation |
| author |
Arias Borrego, Ana Callejón Leblic, Belén Calatayud, Marta Gómez-Ariza, José Luis Collado, María Carmen García Barrera, Tamara |
| author_sort |
Arias Borrego, Ana |
| title |
Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies |
| title_short |
Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies |
| title_full |
Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies |
| title_fullStr |
Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies |
| title_full_unstemmed |
Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies |
| title_sort |
insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota: current analytical methodologies |
| publisher |
Taylor & Francis |
| publishDate |
2019-09-18 |
| url |
http://hdl.handle.net/10261/204184 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100008054 http://dx.doi.org/10.13039/501100011011 |
| work_keys_str_mv |
AT ariasborregoana insightsintocancerandneurodegenerativediseasesthroughselenoproteinsandtheconnectionwithgutmicrobiotacurrentanalyticalmethodologies AT callejonleblicbelen insightsintocancerandneurodegenerativediseasesthroughselenoproteinsandtheconnectionwithgutmicrobiotacurrentanalyticalmethodologies AT calatayudmarta insightsintocancerandneurodegenerativediseasesthroughselenoproteinsandtheconnectionwithgutmicrobiotacurrentanalyticalmethodologies AT gomezarizajoseluis insightsintocancerandneurodegenerativediseasesthroughselenoproteinsandtheconnectionwithgutmicrobiotacurrentanalyticalmethodologies AT colladomariacarmen insightsintocancerandneurodegenerativediseasesthroughselenoproteinsandtheconnectionwithgutmicrobiotacurrentanalyticalmethodologies AT garciabarreratamara insightsintocancerandneurodegenerativediseasesthroughselenoproteinsandtheconnectionwithgutmicrobiotacurrentanalyticalmethodologies |
| _version_ |
1777670117822300160 |